Cov tshuaj 17-OH-progesterone. 17-OH-progesterone: tus nqi ntawm cov ntshav

Lub ntsiab aim ntawm qhov kev hormonal voj voog nyob rau hauv cov poj niam thaum lub sij hawm lub cev ntas - ovulation. Thaum lub sij hawm tus txheej txheem no, nws yog nyob rau hauv cov kev tswj ntawm lub hypothalamus. Nyob rau hauv cov ntaub ntawv no, cov tshuaj tswj khoom uas hais tias yog secreted nyob rau hauv lub anterior pituitary caj pas: FSH thiab LH.

tsim ntawm ovulation

Nyob rau hauv lub pre-ovulatory theem ntawm kev coj khaubncaws voj voog ntawm zes qe menyuam follicle undergoes ob peb transformations. Cov kev hloov no yog noj qhov chaw nyob rau hauv tus ntawm FSH. Tom qab lub follicle nce mus txog ib tug me me, raws li zoo li haumxeeb ua si nyob rau hauv LH ovulatory ncov yog tsim. Qhov no yuav tso cov "maturation" ovum (thawj meiotic division). Tom qab no theem discontinuity tshwm sim nyob rau hauv lub follicle tsim, thiab tawm los ntawm kev uas lub qe. Lub caij nyoog nruab nrab ntawm lub ncov thiab ovulation theem ntawm qhov kev txiav txim ntawm 36-48 teev. Thaum lub sij hawm postovulatory theem xaav tshwm sim feem ntau qe mus rau lub tsev me nyuam ntawm cov hlab qe raj. Nyob rau hauv cov ntaub ntawv ntawm fertilization mus rau lub thib peb-plaub hnub ntawm lub embryo penetrates mus rau hauv lub uterine kab noj hniav. Muaj yog nws implantation. Yog hais tias fertilization tsis tau tshwm sim, ces lub qe thaum lub sij hawm hnub tuag nyob rau hauv txoj hlab qe raj.

Tshuaj muab kev koom tes nyob rau hauv lub livelihood ntawm tus poj niam lub tsev me nyuam muaj nuj nqi

Nyob rau hauv lub endocrine qog yog tsim ntawm biologically active sib txuas. Lawv yog cov hu ua cov tshuaj hormones. Nws yog ua tsaug rau lawv ntawm lub hypothalamic-pituitary-ntawm zes qe menyuam system thiab kom ntseeg tau muaj si nyhav kev ua si ntawm me nyuam lub nruab nrog. Txhua compound ua tej yam kev pab raws qib. Ib tug ntawm cov tshuaj muab kev koom tes nyob rau hauv cov txheej txheem nyob rau hauv lub tsev me nyuam system, yog 17-OH-progesterone. Follicular theem ntws nrog ib tug tseem ceeb nce nyob rau hauv nws cov concentration. Qhov no compound yog tsim nyob rau hauv me me qhov ntau nyob rau hauv lub zes qe menyuam. Ua cov ntsiab lus ntawm cov tshuaj yeeb dej caw yog lub ncov theem ntawm PH. Tom qab ntawd, nyob rau hauv nruab nrab ntawm lub voj voog, lub concentration yog txo rau ib tug luv luv lub sij hawm. Progesterone nyob rau hauv lub follicular theem slows endometrial loj hlob tsa los ntawm cov tshuaj no. Cov uas ua compound yog raug transformation. Lub ntsiab ua ua poj niam yog cov cia li cessation ntawm ntau lawm los ntawm lub corpus luteum progesterone voj voog tiav. Qhov no dag extension ntawm lub luteal theem endometrial stroma tsim decidual cov tshuaj tiv thaiv. Nws yog zoo ib yam li cov kev hloov noj qhov chaw nyob rau hauv thaum pib ntawm cev xeeb tub. Progesterone muab kev cai ntawm cov qog nyob rau hauv lub ncauj tsev menyuam, decreases contractility kab noj hniav. Cov compound kuj cheeb ua poj niam.

Cov tshuaj 17-OH-progesterone. piav qhia

Nws yog ib lub precursor steroids. Ntawd adrenal cortisol tsim nyob rau hauv tus ntawm enzymes xws li 11-b 21-hydroxylase los yog hydroxylase. 17-OH-progesterone nyob rau hauv cov poj niam yuav coj los ua ke androstenedione. Qhov no cov ntaub ntawv uas yog ib tug precursor ntawm testosterone thiab estradiol. Nws yog tsim nyob rau hauv lub zes qe menyuam thiab adrenal qog. Cov ntshav progesterone-17-OH tam sim no nyob rau hauv lub dawb thiab khi nrog cov cab kuj nqaijrog li transcortin thiab albumin. Nyob rau hauv lub qhaj ntawv ntawm fertilization tshuaj concentration decreases. Nyob rau hauv cov ntaub ntawv ntawm implantation ntawm lub qe nyob rau hauv lub zes qe menyuam, tus corpus luteum tseem ua nws.

concentration

17-OH-progesterone nce nyob rau hauv thaum sawv ntxov. Yam tsawg kawg nkaus nws txheem qhia thaum lub sij hawm hmo ntuj. Thaum lub sij hawm hnub, nws theem txawv. Thiab compound concentration txawv thaum lub sij hawm lub cev ntas. Ib tug tseem ceeb nce nyob rau hauv cov qib cai lub hnub ua ntej lub LH ncov. Qhov no yog ua raws li los ntawm lub sij hawm ntawm nyiaj pab ntau tshaj concentration (mid-cycle). Thaum lub sij hawm cev xeeb tub, tshuaj yeeb dej caw cov ntsiab lus yog ho muaj zog. 17-OH-progesterone, tus nqi ntawm uas yog txiav txim nyob rau hauv raws li cov hnub nyoog ntawm cov me nyuam yog muaj nyob rau hauv ib tug me me npaum li cas. Loj ntau yog pom xwb nyob rau hauv lub fertile lub sij hawm thiab sai li sai tau tom qab yug me nyuam. Nyob rau hauv cov ntaub ntawv no, nyob rau hauv ntxov ntxov cov me nyuam mos cov ntsiab lus yog tus loj. Thaum lub sij hawm thawj lub lim tiam ntawm lub kev twb kev txuas theem kev uas yuav ntog. Nws sau tseg ib tug hnyav nce thaum lub sij hawm tiav nkauj tiav nraug. Thaum lub sij hawm no lub sij hawm, progesterone-17-OH cov tub ntxhais hluas maj nce mus txog tib lub concentration raws li nyob rau hauv cov neeg laus.

Vim li cas koj xav tau ib tug ntshav kuaj no?

17-OH-progesterone yog ib nrab khoom. Txawm li cas los, nws txoj kev kawm yog ib qho tseem ceeb kauj ruam nyob rau hauv qhov mob ntawm ntau yam pathologies. Los ntawm cov lus tim khawv ntawm txoj kev tshawb fawb muaj xws li ntxiv lawm tshob, hirsutism, voj voog mob. Thaum adrenal hyperplasia raws li ib tug kev kho mob rau cov neeg mob muab steroid hloov txoj kev kho. Yuav kom ntsuam xyuas nws cov hauj lwm zoo tsom xam yog tseem muab. 17-OH-progesterone kawm nyob rau hauv cov me nyuam mos. Nws concentration txoj kev tshawb no xav tias 21-hydroxylase tsis muaj peev xwm. Deficiency ntawm no enzyme cai nyob rau hauv congenital adrenal hyperplasia hom.

Kev npaj rau kev kuaj

Yog hais tias tus kws kho mob tsis muaj lwm lub sij hawm, cov ntshav muab rau lub thib peb rau tsib hnub voj voog. Txoj kev tshawb no twb tau soj xyuas nyob rau hauv ib qho kev npliag plab nyob rau hauv thaum sawv ntxov. Nws yog tsis tso cai rau kev siv ntawm kas fes los sis tshuaj yej. Pub haus dej ntshiab xwb. Txij li thaum kawg noj mov ua ntej cov ntshav pub dawb yuav tsum muaj tsawg kawg yim teev. Kws txawj xav txog nws tsim nyog lawm txoj kev tshawb no ntawm lub thib ob theem ntawm 20-23 hnub. Yog hais tias qhov ntev ntawm lub voj voog ntawm 42 hnub, cov ntshav qauv yog nqa tawm nyob rau hauv lub 35 th hnub. Nyob rau 23rd hnub ntawm thawj theem tseem tseem. Cov theem ntawm progesterone yog txo, tab sis nws tsis qhia ib tug tsis ua hauj lwm ntawm lub luteal theem los yog anovulation. Nws ua rau tsis muaj kev nkag siab rau kev ib txoj kev tshawb no ntawm concentration thaum lub sij hawm cev xeeb tub thiab coj tej tshuaj. Nyob rau hauv cov ntaub ntawv no, ib tug siab 17-OH-progesterone - lub cai. Tej ntsiab lus ntawm prenatal care yog tsis yuav tsum tau.

txhais lus ntawm tau

Raws li hais saum toj no, lub qub theem ntawm cov hormone progesterone, 17-OH nyob ntawm lub hnub nyoog. Tseem ceeb thiab pw ua ke ntawm cov kev kawm. Lub concentration yog txiav txim nyob rau hauv ng / ml. Pom cov ntsiab lus rau cov me nyuam mus txog ib lub hlis - 0-16,63; 1-2- lub hlis. - 1,8-9,7; 3 lub hlis. - 0,07-1,7. Rau cov neeg mob nyob rau hauv ib xyoos - 0-1,65; mus txog 3 xyoos - 0-0,99; los ntawm 3 mus rau 10 - 0,07-1,69. Permissible theem rau cov txiv neej - 0.5-2.1. Rau cov poj niam nyob rau hauv lub follicular theem - 0,41-2,72; ovulatory - 0,33-2,8; luteal - 0,33-2,8. Nyob rau hauv thawj peb lub hlis thaum progesterone-17-OH yuav tsum tam sim no nyob rau hauv ib tug concentration ntawm 1,17-5,62; Ob - 1,17-6,7; nyob rau hauv lub thib peb - 1,24-11. Nyob rau hauv postmenopausal pom cov ntsiab lus ntawm 0,13-0,51.

adrenal hyperplasia

Nws yog ib tug congenital autoimmune pathology. Feem ntau muaj raws li ib tug tshwm sim ntawm tsis muaj peev xwm ntawm enzymes muab kev koom tes nyob rau hauv lub synthesis ntawm steriods kho. Tsis muaj tebchaw tej zaum yuav muaj ntau degrees ntawm heev. Nyob rau hauv nws kiag nyob rau hauv congenital hyperplasia npaj virilization (lub tsim ntawm txiv neej zoo nyob rau hauv cov poj niam). Nyob rau hauv loj heev zaum, ib qho enzyme deficiency provokes loj ua txhaum nyob rau hauv lub synthesis ntawm steriods kho, ntsev poob, uas yuav ua tau txoj sia. Ib nrab tsis muaj peev xwm ntawm cov enzyme twb pom nyob rau hauv neeg laus, nws kuj yuav congenital nyob rau hauv cov xwm. Nyob rau hauv cov ntaub ntawv no, chiv ua txhaum tshwm sim nyob rau hauv ib tug latent daim ntawv no, thiab yog tsis ib txwm kuaj nyob rau hauv thaum yau. Tsis hnov synthesis ntawm enzymes yuav muaj ib tug hnyav cim. Nyob rau hauv tus ntawm cov nyom pathological yam tsub kom nrog qhov tshwm sim ntawm kev haumxeeb thiab morphological kev hloov nyob rau hauv lub adrenal qog, uas zoo sib xws ces congenital syndrome. Raws li ib tug tshwm sim ntawm cuam tshuam kev sib deev kev loj hlob ntawm cov tub ntxhais hluas. Nyob rau hauv ib tug ntau ntawm progesterone, 17-OH tsom nws ua si rau lub synthesis ntawm androgens. Cov tebchaw circulating nyob rau hauv kiag thiab ntxias cov ntxhais qhia ntawm kev sib deev yam ntxwv ntawm cov txiv neej hom. Yog li ntawd, txoj kev tshawb ntawm nws cov concentration yog qhov tseem ceeb nyob rau hauv kev txiav txim cov hauj lwm zoo ntawm kev kho mob tau txais.

Qhov ntau txaus ntshai tsis muaj peev xwm ntawm cov enzyme 21-hydroxylase

Tsis muaj compound teev txo aldosterone tsim. Qhov no adrenal hormone muab kev cai ntawm cov dej thiab ntsev tshuav nyiaj li cas, zoo nyob rau hauv lub cev ntawm ntsev. Nyob rau hauv cov me nyuam mos, muaj yog ib tug "ntsoog losses." Rau xws li ib tug mob yus los ntawm ib tug txuam nrog kua nyob rau hauv loj qhov ntau. Nyob rau tib lub sij hawm rau lub cev kom nquag thim qhov kev tsim nyog ntsev. Raws li ib tug tshwm sim, lub poov tshuaj ntsiab lus pib nce, thiab sodium - poob. Ib nrab enzyme insufficiency yus erased soj ntsuam daim duab. Sijhawm twg los ntawm tsis muaj peev xwm tshwm sim nyob rau hauv lub keeb kwm yav dhau ntawm kev ua txhaum ntawm tiav nkauj tiav nraug thiab kev loj hlob nyob rau hauv tiav nkauj tiav nraug, thaum ib tug laus muaj hnub nyoog - nrog ntxiv lawm tshob thiab tsis hnov thaum lub sij hawm lub cev ntas, cov ntxhais - nrog hirsutism.

xaus

Cov kev ua ntawm tus txiv neej pw cov tshuaj hormones yog ib tug ntawm cov kev txiav txim yam yog tsis tsuas cov hauj lwm ntawm lub tsev me nyuam system nyob rau hauv cov poj niam. Cov tshuaj tiv thaiv ntawm lub tebchaw, lawv stability thiab ib txwm ua si, kev koom tes nyob rau hauv sib txawv dab, raws li tau zoo raws li lub xub ntiag ntawm ib qho kev pom concentration muaj ib feem nyob rau hauv lub zuag qhia tag nrho kev loj hlob ntawm lub cev thiab kev noj qab nyob rau hauv dav. Qhov tshwj xeeb ceeb toom hais tias tej sib txawv los ntawm uas twb muaj lawm cov qauv nyob rau hauv cov tshuaj tsis yog ib txwm ib tug kos npe rau ntawm pathology. Nyob rau hauv no kev twb kev txuas, nyob rau hauv txhua rooj plaub nws tsis yuav tsum tau kev kho mob. Txawm li cas los, cov kws kho mob pom zoo kom mus tsis tu ncua pub yus cov ntshav mus rau lub chaw kuaj tsom xam, kom dhau xeem. Ib txhia cov kab mob muaj ib tug latent daim ntawv thiab untimely mob ua rau yus loj txim. Ntawm kev tseem ceeb yog lub xeev ntawm hormonal cov poj niam. Tsis tau nyob rau hauv thaum yau mob nrog lub hnub nyoog loj zuj zus, yuav ua disruptions nyob rau hauv hauj lwm ntawm lub tsev me nyuam thiab lwm yam systems nyob rau hauv lub cev. Nyob rau hauv tej rooj plaub, ntxiv lawm tshob - ib qho ntawm feem ceev teeb meem niaj hnub no - yog cov kev tshwm sim ntawm lig mob. Rau cov neeg mob uas tau txais hloov txoj kev kho, yuav tsum tau mus kuaj ib ce thiab kev kuaj ntshav. Cov kev tshwm sim pub tsis tau tsuas yog rau kev ntsuam xyuas cov tshuaj miv nyuas siv zug ntawm cov tshuaj, tab sis kuj yuav tau kho lawv daim ntawv thov tswvyim.