Vim li cas cov qauv yog muaj Coombs?

Coombs - ib lub laboratory kuaj uas tso cai rau los mus txiav txim lub cev nyob rau hauv lub ntshav los yog cov ntshav liab ntawm tes nto. Qhov no txoj kev tso cai rau kom kuaj tiv thaiv kab mob hemolytic anemia, nrog rau cov me nyuam mos, raws li zoo raws li qhia hemolytic transfusion tshua. Coombs yog nquag siv nyob rau hauv forensic science thiab noob caj noob ces kev tshawb fawb los mus txiav txim lub erythrocyte antigens. Raws li tag nrho cov kev cai ntawm tej kev tsom xam ua rau nws tau txais lub feem ntau txhim khu kev qha tau.

Lub hom phiaj ntawm antiglobulin xeem

Direct Coombs xeem yuav ntes anti-erythrocytic tshuaj, uas yog tsau nyob rau erythrocytes. Zoo tshuaj tiv thaiv thaum ib tug zoo li txoj kev tshawb no cov ntsiab lus rau txoj kev loj hlob ntawm autoimmune hemolytic anemia. Nws yuav tsum tau muab sau tseg hais tias ib tug tsis zoo tshwm sim tsis cais hauv lub xub ntiag ntawm autoimmune kab mob, txij li thaum cov tshuaj feem ntau pom nyob rau hauv free daim ntawv no, i.e. muaj tsis muaj kev twb kev txuas nrog erythrocytes. Nyob rau hauv xws li mob nws yog advisable mus nqa tawm lub indirect Coombs xeem, uas yuav txiav txim seb lub autonomous cov neeg ua hauj nyob rau hauv cov ntshiab.

Yuav ua li cas yog tus tsom xam?

W Bundled venous ntshav ntawm tus neeg mob yog nqa tawm nyob rau hauv ib qho kev npliag plab nyob rau hauv thaum sawv ntxov, txawm lub fact tias muaj tseem ceeb tshaj uas txw tau zaum kawg tshwm sim ntawm qhov kev xeem no, nws yuav tsis qhia. Khw cov ntaub ntawv uas tso cai noj 2 mus rau 8 ° C tsis ntev tshaj li xya hnub. Yuav kom ntsuas ntawm txoj kev tshawb no twb raws li leej li sai tau, rau tag nrho cov ntshav thaum lub sij hawm thawj ob teev yuav tsum tau xa mus rau lub chaw kuaj. Tob Coombs qauv yuav tsum qhia ib tug tsis zoo tshwm sim, qhia cov tsis tuaj kawm ntawv ntawm hemolytic hloov nyob rau hauv lub cev.

deciphering tag nrho

Coombs yog es laborious kev tshawb fawb txoj kev, uas yuav tsum tau ceev faj thiab leej tiav. Thaum uas siv cov xws li ib tug xeem tej zaum yuav ces yuav tsum ib co teeb meem uas yog txuam nrog rau tsis yog txhais ntawm cov lus kawg tau vim tsis muaj zog manifestation ntawm zoo tshua. Nws yuav tsum tau muab sau tseg tias unreliability tsom - namely zoo Coombs - tej zaum yuav ua tau ib tug rau txim ntawm inefficient ntxuav erythrocytes kev sib cuag nrog fatty
nto thiab neutralization Cheebtsam antiglobulin reagents ntshiab. Lwm disadvantage ntawm no txoj kev yog lub khov ntawm txoj kev tshawb no coj cov ntaub ntawv uas tso uas muaj tej yam ntxwv.

Qhov ua rau ntawm cuav-tsis zoo tshwm sim muaj peev xwm yuav ntev li tuav ncua kev kawm ntawv ntawm erythrocytes nyob rau hauv resuspension. Erroneous tau kuj yog vim muaj cov xub ntiag ntawm anticomplement antibody impurities uas yog adsorbed rau ntawm qhov chaw thaum lub sij hawm tsim kom loj hlob ntawm lub xeem erythrocytes, li no tsim cov tsos ntawm ib tug zoo tshwm sim. Yog hais tias koj ua tib zoo ntxuav xeem mus kuaj thiab saib xyuas cov tshuaj tiv thaiv tej yam kev mob, cov disadvantages yuav tau yooj yim muab tshem tawm, uas yuav ua rau kom qhov uas yuav muaj tau lub feem ntau txhim khu kev qha kev ntsuas ntawm Coombs xeem.