Koj lub paj hlwb tau laus yuav ua li cas sai sai? Zaum tau pom tseem ceeb noob

Koj lub paj hlwb yuav pib muaj hnub nyoog sai npaum li cas thaum koj tig 65 xyoo. Los yog tej zaum nws yuav tsis pib. Nws hloov tawm, nws yog nyob ntawm dab tsi version ntawm ib tug noob nyob rau hauv koj genome. Nws yog zaum tau pom nyob rau hauv tsis ntev los no kev tshawb fawb. Cov soj ntsuam ntawm muaj sab ib lub noob uas tswj cov kev ceev ntawm uas koj lub paj hlwb yog laus, thiab nyob rau tib lub sij hawm lawv hais tias ib tug version ntawm no noob tej zaum yuav muab kev tiv thaiv tiv thaiv ib tug loj tus naj npawb ntawm muaj hnub nyoog txog neurological kab mob xws li ua tem toob dementia.

Noob uas yuav tiv thaiv koj los ntawm dementia?

Qhov no noob, hu ua TMEM106B, pib ua ib ncig ntawm lub lub sij hawm ib tug neeg puv 65 xyoo. Tsis ntev tom qab ntawd, nyob rau hauv cov neeg uas muaj ib tug nyob rau hauv ib tug phem version ntawm cov noob, lub hlwb yuav saib 10-12 lub xyoo laus tshaj lub hlwb ntawm cov neeg uas muaj ib tug nyob rau hauv zoo, zoo version ntawm cov noob. Qhov no discovery yuav pab cov kws kho mob qhia uas cov txiv neej yog thaum nce kev pheej hmoo ntawm tshwm sim ntawm neurological kab mob tej yam kev mob vim lub fact tias lawv muaj ib tug phem version ntawm cov noob. Nws tseem yuav pab nyob rau hauv cov creation ntawm kev kho mob khoom, tej yam uas yuav npaj mus rau lub noob los muab cov neeg uas muaj ib tug ntau noj qab nyob zoo laus hlwb.

Qhov tseem ceeb tshaj rau tag nrho cov noob

Nyob rau hauv xyoo tsis ntev los no, zaum tau sab ib tug loj tus naj npawb ntawm cov noob txuam nrog tus kab mob Alzheimer thiab Parkinson tus thiab lwm yam neurological kab mob. Txawm li cas los, cov noob yog tau piav xwb ib tug me me ib feem ntawm cov kab mob. Raws li peb paub niaj hnub no, lub ntsiab uas muaj feem yuav ceeb rau neurodegenerative kab mob no yog laus. Ib yam dab tsi hloov nyob rau hauv lub hlwb thaum koj tau txais xyoo rov saud, thiab qhov no ua rau lub fact tias koj ua raug rau tus kab mob ntawm lub paj hlwb. Cov kev tshuaj ntsuam genetic cov lus qhia uas muab TMEM106B noob tej zaum yuav hais tias "ib yam dab tsi." Thiab cov teams yuav yog tiv thaiv cov teeb meem tshwm sim los ntawm kev laus los yog thab lawv. Yog hais tias koj saib nyob rau ib pab pawg neeg ntawm cov neeg laus cov neeg, ib co ntawm lawv yuav saib loj tshaj lwm leej lwm tus, thiab ib co -molozhe. Raws nraim tib yam sib txawv nyob rau hauv kev laus yuav tsum tau cai nyob rau hauv lub frontal cortex, ib lub paj hlwb cheeb tsam lub luag hauj lwm rau txoj kev xav muaj dab.

Tshiab kev tshawb fawb nyob rau hauv cov tom qab ntawm yav tas los

Previous kev tshawb fawb tau txuas no noob nrog ib tug tsawg daim ntawv ntawm dementia hu ua frontotemporal degeneration. Tab sis ib tug tshiab txoj kev tshawv no qhia tau hais tias qhov no noob yog ntau npaum li cas lug txuam nrog lub hlwb laus thiab txiav txim yuav ua li cas zoo cov neeg laus kom lawv cov kev txawj ntse muaj nuj nqi. Yuav kom txiav txim dab tsi yuav tswj lub hlwb laus, ob tug soj ntsuam analyzed genetic ntaub ntawv los ntawm ntau tshaj 1200 tib neeg lub hlwb kuaj tau koom rau cov neeg uas tsis tau paub hais tias muaj ib yam neurodegenerative kab mob thaum lawv tseem ciaj sia. Lawv teem rau lub ob peb puas noob uas yog ua rau kom cov miv nyuas siv zug ua ntej lawm los yog poob thaum lub sij hawm tib neeg laus. Zaum tau ua ib daim ntawv ntawm cov ntaub ntawv no, uas lawv hu ua "differential laus". Qhov no teeb qhia tau hais tias qhov txawv nruab nrab ntawm tus tam sim no (los yog sib lawv liag) lub hlwb muaj hnub nyoog thiab nws tiag tiag uas muaj hnub nyoog.

Yuav ua li cas yog lub peculiarity ntawm no noob?

Ib tug noob, tib TMEM106B, sawv tawm los ntawm tus so, uas qhia nws tus kheej raws li lub differential laus ntawm lub cav. Nws hloov tawm hais tias qhov no noob ntawm lwm yam uas mob thiab tsis neurons nyob rau hauv lub hlwb. Tab sis qhov no noob muaj ob tug cov ntaub ntawv, los yog es, ob alleles: tus thawj tug yog txuam nrog rau kev raug mob ntawm ceev laus ntawm lub paj hlwb, thaum lub lwm yam yog ib tug tiv thaiv thiab tiv thaiv kom txhob ceev laus. Txhua tus neeg muaj ob versions ntawm no noob nyob rau hauv lub genome, thiab kwv yees li ntawm peb caug feem pua ntawm cov pejxeem ntawm ob versions - phem. Tsib caug feem pua ntawm cov pejxeem, ib tug allele yog kev tiv thaiv, thiab lwm yam tsis zoo li cas rau lub paj hlwb, zoo, thiab cov seem nees nkaum feem pua yog ob tiv thaiv alleles.

Ib tug ntau yam ntawm ob peb ua ke, thiab yog dab tsi no txhais tau tias

Raws li deb raws li tau txiav txim ntawm lub sij hawm no, tsis zoo zoo ntawm lub ob alleles yog cumulative. Qhov no txhais tau hais tias tib neeg lub hlwb, uas muaj ob tug tsis zoo alleles, zoo nkaus li tsib lub xyoo laus tshaj lub hlwb ntawm cov neeg uas muaj tib tug tsis zoo allele. Thiab lawv lub hlwb, nyob rau hauv lem, zoo nkaus li tsib lub xyoo laus tshaj lub hlwb ntawm cov neeg uas tsis muaj qhov tsis zoo alleles. Yog li ntawd ib tug ntawm lub ntsiab hypotheses txog lub noob yog ib tug raws li uas TMEM106B ntawm lwm yam uas systematic teb nyob rau hauv tib neeg lub hlwb nyob rau lub hnub nyoog stressors. Raws li ib feem ntawm tib txoj kev tshawb no, tus neeg tshawb fawb ntsia lub hlwb ntawm cov neeg uas thaum lub sij hawm nws lub neej raug kev txom nyem los ntawm tus kab mob Alzheimer los yog Huntington thiab pom raws nraim tib yam nyhuv ntawm cov noob nyob rau hauv cov laus lub hlwb. Nws yog ib nqi nco ntsoov hais tias qhov no noob yuav zoo thaum nws nce mus txog tus muaj hnub nyoog ntawm 65, ua ntej tag nrho cov neeg yog nyob rau tib theem.