"Gabapentin" thiab haus dej haus cawv: xyuas. "Gabapentin": cov lus qhia rau kev siv, ua siab ntev testimonials thiab cov kws kho mob

Los ntawm lub sij hawm rau lub sij hawm, nqaij tu-sauv thab ntau neeg. Txawm li cas los, ob peb cov neeg xav txog vim li cas xws xeev feem ntau tshwm sim.

Raws li cov kos duab, qaug dab peg yuav tsum sib txawv: generalized (tonic, clonic, tonic-clonic thiab myoclonic) thiab ib nrab (yooj yim thiab complex). ib tug yeeb tshuaj siv los kho qaug dab peg xeem raws li "Gabapentin". Cov lus qhia rau kev siv, xyuas thiab contraindications ntawm cov tshuaj yuav tsum tau muab nthuav me ntsis tom qab.

Nws yuav tsum tam sim ntawd tau muab sau tseg tias, ib feem qaug dab peg tsiag ntawv los ntawm kev qhaj ntawv ntawm tsis nco qab. Tej tsawg mob. Lawv tshwm sim clonic qaug dab peg xwm uas ib leeg ob txhais tes, ob txhais taw thiab lub ntsej muag.

Muaj pes tsawg leeg, hauj lwm, ntim khoom thiab nws muaj pes tsawg leeg

muag medicament "Gabapentin" Nyob rau hauv dab tsi daim ntawv no? Testimonials qhia hais tias qhov no tshuaj yuav tau muas ntawm ib tug muag tshuaj nyob rau hauv daim ntawv ntawm ib qho nyuaj gelatin tsiav tshuaj nyob rau hauv dawb. Lawv cov ntsiab lus yog ib tug dawb los yog yellowish hmoov tshuaj.

Lub active ingredient ntawm no neeg uas sawv cev gabapentin. Tsis tas li ntawd, nws muaj xws li ib tug ntxiv tshuaj nyob rau hauv daim ntawv ntawm sodium carboxymethyl starch, calcium stearate thiab microcrystalline cellulose. Raws li rau lub tsiav tshuaj, lawv muaj gelatin thiab titanium dioxide.

Nyob rau hauv ib lub pob muag cov tshuaj "Gabapentin"? Consumer xyuas hais tias nyob rau hauv txee ntawm cov chaw muag tshuaj cov tshuaj muaj nyob rau hauv cov duab los qhia packs, uas yog muab tso rau tog twg los polymeric tsiav tshuaj poom los yog contour ntawm lub cell.

Lub hauv paus ntsiab lus ntawm kev txiav txim ntawm ib tug yeeb tshuaj

Yuav ua li cas puas cov tshuaj "Gabapentin"? Cov lus qhia (xyuas ntawm cov tshuaj uas hais no nyob rau thaum xaus ntawm qhov tsab xov xwm) qhia tias cov tshuaj nyob rau hauv nws cov qauv yog zoo heev rau cov neurotransmitter gamma-aminobutyric acid (GABA rau luv luv). Txawm li cas los, nws yuav tsum tau muab sau tseg tias hauv paus ntsiab lus ntawm nws cov kev txiav txim yog fundamentally sib txawv ntawm lwm yam tshuaj uas nrog GABA-receptors (e.g., valproate, barbiturates, benzodiazepines, GABA transaminase inhibitors, GABA reuptake inhibitors, GABA agonists thiab prodrugs ntawm GABA).

Saib cov tshuaj muaj tsis muaj GABA-ing zog thiab tsis cuam tshuam rau capture thiab cov metabolism hauv ntawm GABA. Kev tshawb fawb cov kws txawj pom tau tias cov active ingredient ntawm tus neeg saib xyuas los ntawm kev ruaj rau α2-δ-subunit ntawm voltage-dependent calcium raws, zoo heev txo lub khiav ntawm calcium ions, uas ua si ib qho tseem ceeb heev luag hauj lwm nyob rau hauv qhov pib ntawm neuropathic mob.

Nta anticonvulsant tshuaj

Yuav ua li cas lwm yam khoom yog muaj los ntawm cov tshuaj "Gabapentin"? Xyuas ntawm cov kws kho mob hais tias nws yog heev zoo rau neuropathic mob. Qhov no tshuaj thiaj li glutamate-dependent neuronal tuag, ua GABA synthesis, raws li zoo raws li cov txheej txheem ntawm kev tsuj ntawm neurotransmitter kev tso cai thiab monoamine pawg.

Peb tsis tau hais tias nyob rau hauv clinically yam tsi ntsees ntawm tshuaj "Gabapentin" tsis khi rau receptors ntawm lwm yam tshuaj (los yog neurotransmitters), xws li GABAA receptors thiab GABAB, thiab glutamate, benzodiazepine receptors, glycine, thiab N-methyl-D- aspartate.

Tsis zoo li "Carbamazepine" thiab "phenytoin", xam tias yog qhov medicament tsis nrog sodium raws. Kev npaj "gabapentin" cov attenuates cov teebmeem ntawm glutamate receptor agonist xws li N-methyl-D-aspartate. Ntxiv mus, nws ho thiaj li qhov kev tso tawm ntawm monoamine neurotransmitters.

Cov kev tig tau thaj chaw ntawm cov tshuaj

Yuav ua li cas yog lub xam qhovkev kev tig tau tsis tsiav tshuaj "Gabapentin"? Testimonials yuav tsis tau los teb lo lus nug no. Yuav kom nrhiav tau nws, koj yuav tau tig mus txog tej tub txawg los yog muab ntim rau cov lus qhia.

Raws li yav tas, lub bioavailability ntawm hais tias tshuaj tsis yog xwm yeem mus rau ntau npaum saws. Thaum tus nqi ntawm cov tshuaj yog txo.

Thaum tau txais cov medicament mus rau hauv nws lub siab tshaj plaws ntshav concentration cai tom qab 3 h. Lub meej bioavailability ntawm cov tshuaj nyob rau hauv tsiav tshuaj yog kwv yees li 60%. Khoom noj khoom haus, xws li ib tug heev muaj roj, muaj tsis ntxim rau cov kinetics ntawm cov tshuaj.

Tsis koom nrog nws "Gabapentin" ntawm tus neeg mob cov ntshav yog nqa tawm los ntawm ib tug linear qauv. ib nrab-lub neej lub sij hawm yog ywj siab ntawm cov tshuaj thiab yog kwv yees li 5-7 teev.

Cov kev tig tau thaj chaw ntawm cov tshuaj tsis hloov txawm tias thaum nws yog thov dua. Lub concentration ntawm kev siv yeeb tshuaj nyob rau hauv cov ntshav yuav ua yuav kwv yees raws li nyob rau hauv cov kev tshwm sim ntawm nws ib koob tshuaj.

Lub medicament "Gabapentin" tshuam tsis khi rau ntshav cov nqaijrog (tsawg tshaj li 3%). Nws yog tso tawm nyob rau hauv unchanged daim ntawv los ntawm lub ob lub raum.

Metabolize cov tshuaj tsis raug. Ntxiv mus, nws tsis ntxias hepatic oxidative enzymes, uas yog muab kev koom tes nyob rau hauv lub metabolism ntawm lwm yam tshuaj.

Lub clearance ntawm tus neeg saib xyuas los ntawm cov ntshav txo nyob rau hauv cov neeg laus thiab cov neeg mob uas tsis hnov raum muaj nuj nqi.

Kev npaj "gabapentin" yog muab tshem tawm los ntawm lub cev los ntawm hemodialysis.

Indications yuav tau txais tshuaj

Nyob rau hauv dab tsi kab mob peb xav yog tshwj xeeb yog zoo tshuaj? Yuav ua li cas cov neeg no hais txog qhov no tswv yim?

"Gabapentin" zoo manifests nws tus kheej nyob rau hauv:

• neuropathic mob nyob rau hauv neeg laus cov neeg mob (18 xyoo thiab laus dua);
• monotherapy los yog raws li ib tug complementary tshuaj rau cov kev kho mob ntawm ib nrab qaug dab peg, los theem nrab generalization rau cov neeg laus thiab cov me nyuam hluas los ntawm 12 xyoo ntawm lub hnub nyoog.

Contraindications tau txais tshuaj

Yuav ua li cas yog cov contraindications tshuaj muaj "Gabapentin"? Xyuas hauv daim ntawv thov qhia tias nws muaj ib tug tsis zoo ntxim rau lub cev, yog tias cov tshuaj tau txais nyob rau hauv:

• npau taws me ntsis rau ib yam ntawm cov tshuaj yeeb dej caw;
• ib nrab qaug dab peg nyob rau hauv lub hnub nyoog ntawm 12 xyoo.

Tshwj xeeb kev kho mob yog ib tug txhais tau tias kws kho rau raum tsis ua hauj lwm.

Yuav ua li cas kuv yuav tsum tau coj cov tshuaj "Gabapentin"?

Xyuas (neuralgia no tshuaj pab zoo heev) lub xeev uas lub tshuaj yuav tsum tau muab nkaus xwb los ntawm ib tug kws kho mob, tom qab qhov tseeb kuaj mob.

Nkaws tsiav tshuaj noj ntawm ncauj los nqos tag nrho, nyob rau hauv lawv daim ntawv no. Cov tshuaj yuav tsum tau noj tsis hais tus noj mov, ntxuav cia nrog tshaj kua. Yog hais tias koj xav tau kom txo tau ntau npaum cov tshuaj mus rho los yog hloov nws analogue, ces qhov no yuav tsum tau ua maj tshaj ib lub lim tiam.

Kev kho mob ntawm neuropathic mob rau cov neeg laus

Raws li nyob rau hauv lub xeev no ua xam tau tias yog tshuaj? Yuav ua li cas cov neeg no hais txog kev kho mob xyuas? "Gabapentin" zoo heev manifests nws tus kheej rau neuropathic mob. Nyob rau hauv kev kho cov kev pib txhua txhua hnub koob tshuaj yuav tsum tau 900 mg. Hais tias tus nqi yog muab faib ua peb feem. Yog hais tias yuav tsum tau, lub koob tshuaj yog maj nce mus rau ib tug tshaj plaws (i.e., mus txog 3600 mg ib hnub twg).

ib nrab qaug dab peg

Yuav ua li cas kuv yuav tsum tau coj cov tshuaj "gabapentin" nyob rau hauv tus kab mob no? Xyuas tau tshaj tawm hais tias lub cuab tam yuav tsum muab tsis tau tsuas yog rau cov neeg laus, tab sis cov hluas los ntawm 12 xyoo.

Lub koob tshuaj rau ib nrab qaug dab peg xam tau tias yog 900-2400 mg ib hnub twg. Kev kho mob ntawm tus kab mob no yuav pib nrog 300 mg ntawm cov tshuaj peb zaug ib hnub twg. Tom qab txhua txhua hnub koob tshuaj yuav tsum tau nce mus 900 mg, thiab ntau thiab mus txog rau 2400 mg ib hnub twg (muab faib ua peb sib npaug zos koob tshuaj).

Lub sij hawm caij nyoog nruab nrab koob tshuaj ntawm cov tshuaj nyob rau hauv nws triple txais tos yuav tsum tsis txhob muaj ntau tshaj li 12 teev (yuav tsum tsis txhob resumption ntawm qaug dab peg).

phiv

Yuav ua li cas phiv tshuaj tej zaum yuav tshwm sim nyob rau hauv cov neeg mob uas tau txais anticonvulsant? Yuav ua li cas cov neeg no hais txog qhov no neeg xyuas? "Gabapentin" nyob rau hauv cov kev kho mob ntawm neuropathic mob yuav ua rau:

• asthenia, lo raug mob, cov kev mob ntawm txawv localization, rov qab mob, kab mob, khaub thuas syndrome, mob taub hau, koj qhov hnyav nce, peripheral edema;
• moj yam ntxaug, ataxia, amnesia, hypoesthesia, tsis meej pem, kiv taub hau, impaired kev xav, nkees nkees, co;
• cem quav, flatulence, raws plab, ntuav, qhov ncauj qhuav, dyspepsia, xeev siab, mob plab;
• daim tawv nqaij sawv pob;
• ua tsis taus pa, mob caj pas;
• amblyopia.

Nyob rau hauv cov kev kho mob ntawm ib nrab qaug dab peg, cov tshuaj txhawb mus rau lub tsos:

• rov qab mob, qaug zog, kub taub hau, mob taub hau, kab mob, peripheral edema, koj qhov hnyav nce, qaug zog, malaise, lub ntsej muag edema;
• cem quav, kho hniav kab mob, raws plab, kem plab, muaj zog qab los noj mov, qhov ncauj qhuav los sis caj pas, xeev siab los yog ntuav, mob plab, tsam plab, anorexia, gingivitis;
• cov tsos mob ntawm vasodilation los yog tawg;
• leukopenia, purpura;
• cov pob txha lov, myalgia thiab arthralgia;
• amnesia, ataxia, tsis meej pem, incoordination, kev nyuaj siab, dysarthria, kev xav lability, insomnia, nervousness, nystagmus, nkees nkees, txawv txav xav, co, nqaij laim, kiv taub hau, hyperkinesia; nce, weakening los yog tsis tuaj kawm ntawv ntawm reflexes, ntxhov siab vim, paresthesia, heev;
• abrasions, pob txuv, daim tawv nqaij khaus, daim tawv nqaij ua pob liab vog;
• hnoos, pharyngitis, txhaws ntswg, mob ntsws;
• amblyopia, diplopia, qhov muag plooj tsis pom kev;
• mob txeeb zig, impotence.

tus neeg mob ntawm overdose

Yuav ua li cas yog cov tsos mob ntawm overdose yuav ua kom hais tias medicament? Yuav ua li cas txog qhov no hais tias kev xyuas? "Gabapentin" overdose yuav ua rau ob lub zeem muag, kiv taub hau, nkees nkees, impaired kev hais lus, nkees thiab mob raws plab.

Yuav kom tshem tawm tej lub xeev symptomatic txoj kev kho, raws li tau zoo raws li tus neeg ntxuav lub plab thiab muab nws tshuab txais charcoal.

Cov neeg mob uas mob loj heev raum insufficiency, hemodialysis yog muaj.

Tshuaj "Gabapentin" thiab haus dej haus cawv

Xyuas tshwj xeeb qhia txog hais tias cov efficiency ntawm qhov suav hais tias cov tshuaj yog heev. Tab sis nws tsuas yog nyob rau hauv cov kev tshwm sim hais tias lub sij hawm ntawm nws daim ntawv thov tus neeg mob yog kiag li uas siv haus dej haus cawv.

Yog hais tias cov tshuaj yog ua ke nrog haus dej haus cawv, tus neeg mob tej zaum yuav ho paug phiv tshuaj los ntawm lub hauv paus poob siab system (stupor, ataxia, etc.).

tshuaj cov kev sib tshuam

Tshuaj "gabapentin" nyob rau hauv neuroscience, xyuas uas muaj ntau tshaj li zoo, yuav muab tag nrho tsis tau rau txhua yam tshuaj.

Raws li cov lus qhia, antacids txo lub bioavailability ntawm cov tshuaj.

Myelotoxicity tshuaj kom haematotoxicity tsiav tshuaj "Gabapentin".

Thaum ua ke nrog morphine nws tshuaj yog tsis tau hloov. Txawm li cas los, thaum xws li ib tug ua ke yuav tsum tau ua tib zoo saib xyuas tej zaum phiv cov tshuaj tiv thaiv ntawm poob siab system.

Saib medicament yuav tsum tau noj ib txhij nrog antiepileptic tshuaj (e.g., "pentobarbital", "Carbamazepine", "Phenytoin" thiab valproic acid) thiab lub qhov ncauj contraceptives. Nyob rau hauv cov ntaub ntawv no, nws tsis hloov lub kinetics.

tej tswv yim pom zoo

Txawm tias muaj tseeb hais tias cov ntsoos ntsoos syndrome nrog qhov tshwm sim ntawm qaug dab peg nyob rau hauv cov kev kho mob ntawm "gabapentin" tsis yog cim los ntawm ib tug ceev cessation ntawm kev kho mob nrog antiepileptic tshuaj nyob rau hauv cov neeg uas muaj ib nrab qaug dab peg yuav tseem ntxias muaj zog convulsions.

Saib cov tshuaj tsis yog ib qho zoo txhais tau tias kom tshwj kom txhob nrog tsis tuaj kawm ntawv tau qaug dab peg.

Cov neeg uas xav tau kev complex kho nrog morphine, tej zaum yuav xav tau ib tug muaj zog tshuaj ntawm "gabapentin". Nyob rau hauv cov ntaub ntawv no, xyuas kom meej qhov xyuas ntawm tus neeg mob rau txoj kev loj hlob ntawm koj nkees nkees. Thaum nws paub cov tshuaj txhaj koob tshuaj yuav tsum tau txaus txo.

Thaum ua ke "gabapentin" nrog rau lwm cov anticonvulsant tshuaj tau qhia tsis tseeb zoo tau nyob rau hauv qhov kev txiav txim ntawm cov protein nyob rau hauv cov zis siv xeem ib daim hlab Ames N-Multistix SG. Nyob rau hauv no hais txog, rau tej cov kev tshawb fawb pom zoo kom siv ntawm ib lub nag lossis daus los ntawm txoj kev sulfosalicylic acid.

Xyuas cov tub txawg thiab tau txais kev pab

Feem ntau cov kev xyuas txog cov kws kho mob thiab cov neeg mob txog qhov "Gabapentin" npaj zoo. Cov ntaub ntawv hais tias cov tshuaj zoo tiv nrog lub hauj lwm. Txawm li cas los, thaum nws ua ke nrog haus dej haus cawv ntau tsim mob loj heev phiv tshuaj nyob rau hauv lub paj hlwb.

Nws yog tsis yooj yim sua tsis tau nco ntsoov lub fact tias cov ceev tshem ntawm cov tshuaj yuav ua rau tus neeg mob blunted nco qab, nkees thiab ib tug phem mus ob peb vas.

Muaj coob tus neeg tau muab sau tseg tias kom tsawg ntawm no txhais tau tias lawv muaj ib tug kev nyuaj siab thiab suicidal xav. Tsis tas li ntawd, cov tshuaj feem ntau ua rau txoj kev loj hlob ntawm mob pancreatitis.

Kws txawj pom zoo kom mus tshuaj kev kho mob "Gabapentin" xwb nyob rau hauv lub saib xyuas ntawm ib tug kws kho mob uas yuav tsum tau sai sai kho cov tshuaj regimen raws li xav tau.