Cov tshuaj "Amiodarone": analogues, cov lus qhia, xyuas

Lub plawv, raws li koj paub, peb lub ntsiab lub cev, tiam sis feem ntau tsis. Nyob rau hauv thiaj li yuav restore nws ib txwm tau hauj lwm siv ib tug ntau yam ntawm cov tshuaj. Ib tug ntawm lawv yog "Amiodarone". Analogs yog cov ntau ntau kim, raws li yog ua txawv teb chaws thiab tsis yeej ib txwm zoo.

Muaj pes tsawg leeg ntawm cov tshuaj thiab hauv daim ntawv ntawm

Lub medicament "Amiodarone", uas xyuas ib tug ntau yam muaj nyob rau hauv ib ntsiav tshuaj ntawm 200 mg ntawm active ingredient - amiodarone hydrochloride. Cov kev npaj no yog ua ntau tshaj li ib tug daws, qhov twg 3 ml yog 5% ntawm active ingredient.

Koom haum pab tivthaiv muaj li ntawm ib ntsiav tshuaj no yog: qos starch, crystalline microcellulose, lactose, maltodextrin, primelloza, polyvinylpyrrolidone, magnesium stearate.

Cov ntsiav tshuaj them nrog glaze ntawm dawb xim nrog ib tug me ntsis, maj mam qab zib ntxoov ntxoo. Lawv muaj rau hauv daim ntawv ntawm Valium thiab ib tug facet thiab Valium. Yog li ntawd, yog tias tsim nyog, lawv muaj peev xwm tau muab faib ua ob sib npaug zos qhov chaw.

Drug muag nyob rau hauv thawv ntawv, qhov chaw uas ib tug los yog ob tug hlwv nrog kaum ntsiav tshuaj. Cov tshuaj no kuj ua rau hauv lub khob, polymeric thiab yas hwj, uas muaj 30 los yog 100 cov ntsiav tshuaj.

Lub pharmacological mechanism ntawm yeeb tshuaj txiav txim

Antiarrhythmic thiab antianginal zog yog yus "Amiodarone" analogues nyob rau hauv tej rooj plaub yuav hloov nws. Nws anti-arrhythmic txiav txim no yog raws li nyob rau hauv lub yuav txo tau tam sim no ntawm poov tshuaj ions thaum raug membrane hlwb - cardiomyocytes. Nws ua rau ib tug txo nyob rau hauv lub qhov ntswg ntawm uas ntaub ntawv bradycardia.

Kev siv lub tshuaj "Amiodarone" (tshuaj) yuav ua rau kom qhov ntev ntawm lub refractory mob conduction mechanism. Cheeb qhov uas cov conductivity ntawm ob txoj nyob rau hauv cov neeg mob uas muaj mob loj syndrome ntawm Wolff-Parkinson-Dawb syndrome. Nyob rau hauv lem, tus antianginal tshuaj cov nyhuv yog ua rau kom txhob muaj myocardial oxygen noj thiab txo nws rau lub arterial leeg. Yog muaj li ntawm iodine, uas yog nyob rau hauv lub siv ntawm ntau hloov cov ntsiab lus ntawm cov thyroid hormones, uas ua nyob rau hauv lub degree ntawm lawv rau lub myocardium yog txo.

"Amiodarone" muaj ib tug loj zus nyhuv, thiab ib tug qhia tau ntxim rau nws daim ntawv thov no tshwm sim tsuas yog tom qab ib lub lim tiam ntawm kev siv yeeb tshuaj, thiab lub siab tshaj plaws yog mus txog tom qab ob-peb lub lis piam.

Hauv absorbed txog 40% ntawm haus ib tug tshuaj, Cmax ntshav tshwm tom qab 3-7 teev. Cov nyhuv yog tau rau siab rau ob peb lub lis piam. metabolic dab muab qhov chaw tsuas yog nyob rau daim siab, uas ib tug active caij yog tsim dezetilamiodaron, uas yog lub loj metabolite. Rov qab mus nrog secreted kua tsib thiab zis, T1 / 2 - tom qab ib tug tib koob tshuaj ntawm cov tshuaj 3,2-20,7 h, nrog heev txoj kev kho - tom qab 53 ± 24 teev.

Tshuaj "Amiodarone": indications rau kev siv

Muab ib tug yeeb tshuaj rau kev tiv thaiv thiab kev kho mob ntawm arrhythmias, uas muaj peev xwm terminally phomsij tib neeg lub neej, raws li zoo raws li ventricular arrhythmias, ventricular Flutter nyob rau hauv tsis ruaj tsis khov muaj zog kuj siv tshuaj "Amiodarone."

Indications pub rau siv cov tshuaj noj:

• atrial Flutter;
• supraventricular arrhythmias;
• Wolff-Parkinson-Dawb syndrome;
• tshwm sim ntawm tachycardia;
• fibrillyatsionnogo tau ventricles;
• arrhythmia tsob vim mob thiab coronary insufficiency;
• mob ntaub ntawv ntawm coronary mob plawv;
• myocardial infarction.

"Amiodarone": cov lus qhia rau kev siv

Ntsiav tshuaj yog npaj rau qhov ncauj thawj coj tom qab 15 feeb tom qab ib tug noj mov.

Thaum lub sij hawm ventricular fibrillation kab mob ntau npaum pom zoo los ntawm ib tug kws kho mob, yog 800-1200 mg ib hnub twg. Nws yuav tsum tau muab faib ua 3-4 receptions. Cov kev kho mob nyob rau hauv cov ntaub ntawv no tsuas kav txog 5-10 hnub los xyuas kom meej ib tug ruaj khov kev mob ntawm tus neeg mob tej zaum yuav ncua, thiab tus nqi yuav raug txo qis rau 600-800 mg ib hnub twg. Qhov no intensive kev kho mob, uas tom qab hais kom tiv thaiv, ib tug tsawg dua koob ntawm cov tshuaj ntsiab lus.

Therapeutic txij nkawm lub sij hawm yog 7-14 hnub, nyob rau hauv lub sij hawm no ntawm tshuaj noj 200-400 mg. Tej tshuaj volume muab mus rau stabilize tus neeg mob tus mob nyob rau hauv poslereabilitatsionny lub sij hawm.

Feem ntau cov kev kho "Amiodarone" tshuaj thaum tus neeg mob yog nyob rau hauv lub tsev kho mob, thiab nws cov txheej txheem yuav tswj tus kws kho mob. Qhov no ua rau nws tau kom txo tau cov mob tshwm sim thiab ib tus zuj zus kho cov koob tshuaj ntawm cov tshuaj.

Thaum lub medicament kab mob angina siv ob zaug ib hnub twg ntawm 200 mg. Tom qab ob lub lis piam, cov tshuaj yog txo mus ib zaug ib hnub twg. Qhov siab tshaj plaws ib koob tshuaj txhaj koob tshuaj yuav tsum tsis txhob ntau tshaj 400 mg thiab lub hnub - 1200 mg.

Nyob rau hauv appointing cov tshuaj rau cov me nyuam yuav tsum tau borne nyob rau hauv lub siab hais tias cov ntsiav tshuaj muaj feem xyuam rau tus me nyuam sai npaum li cas tshaj ib tug neeg laus. Yog li ntawd, lub koob tshuaj yog xam raws li qhov nyhav ntawm tus me nyuam. Yog li, ib tug kilogram ntawm qhov ceeb thawj yuav tsum poob 10 mg ntawm medicament. Qhov no koob tshuaj yuav tsum tau muab khaws thoob plaws hauv lub kho lub sij hawm ntawm kaum hnub los yog kom txog thaum tus neeg mob tus mob khees me ntsis lawm. Hereinafter, qhov no specification los txo cov kev faib ua feem ntawm 5 mg ib kilogram lub cev hnyav ntawm tus me nyuam. Tiv Thaiv txij nkawm tshuaj noj thiab raws li ib tug kilogram ntawm 2.4 mg ntawm tshuaj "Amiodarone."

Indications mus rau yeeb tshuaj tua tau siv ib tug tov raws li active ingredient ntawm amiodarone hydrochloride nyob rau hauv mob mob arrhythmias. Nyob rau hauv cov ntaub ntawv no, cov tshuaj yog muab intravenously, maj mam txhaj mus rau hauv lub cev nrog ib tug dropper. Ua li no, 250 ml ntawm 5% zib tov rau 1 los yog 2 twb maj mam txhaj tshuaj koob tshuaj 5 mg ib kilogram lub cev hnyav. Thaum lub sij hawm no, tus neeg mob yog saib xyuas los ntawm txoj kev ECG thiab ntshav siab ntsuas readings.

phiv

Yog li ntawd ntau cov tshuaj "Amidaron" nyob rau hauv peb lub teb chaws. Analogs tsis yeej ib txwm muaj peev xwm mus hloov nws. Tab sis txawm qhov zoo los ntawm cov tshuaj nyob rau hauv tib neeg lub cev, tau txheeb thiab cov kev phiv.

Tsis zoo mob mas vim cov tshuaj overdose. Qhov no ua txhaum ntawm cov hlab plawv system, xws li bradycardia, qhov ntswg ntawm muaj nuj nqi tsis ua hauj lwm, lub plawv thaiv, tsis sib haum ntawm lub zog. Tsis tas li ntawd nyob rau ib feem ntawm lub pa system yog pom diffuse interstitial pulmonary fibrosis, interstitial mob ntsws, hamm syndrome - Nplua nuj, mob hauv siab, pulmonary fibrosis, tachypnea, bronchopulmonary chua. Hepatic tsis ua hauj lwm muaj cai thaum tau txais "Amidaron" kev npaj. Ntsiav tshuaj nyob rau hauv uas tsis tshua muaj mob ua rau daj ntseg, kab mob siab, mob npuas paug tej zaum.

Tsis ua raws li ntau npaum yuav ua rau ib tug tseem ceeb tsis txaus ntawm lub qog cov tshuaj hormones, distireoza thiab hypothyroidism, thiab ib co ntawm cov ntxiv kilos. Overdose yuav ua rau muaj kev cuam tshuam ntawm cov nrig txog kev pom apparatus, ua tsub zuj zuj ntawm lipids nyob rau hauv lub cornea rau cov menyuam. Tsis tas li ntawd, muaj ib tug qhia tau pigmentation ntawm daim tawv nqaij, photosensitivity, urticaria los yog erythema. Me ua pob ua xyua tau pom lub ntsej muag, alopecia, dermatitis. Sab los kuj cuam tshuam lub tsev me nyuam muaj nuj nqi nyob rau hauv cov txiv neej. Nyob rau hauv cov neeg mob muaj orchitis, impotence, thiab epididymitis. Heev tsawg thrombocytopenia, raum tsis ua hauj lwm, los yog angioedema vasculitis.

Contraindications rau kev siv ntawm

"Amiodarone" (tswv yim yog tsis ib txwm zoo) yog xaiv nruj me ntsis zuj zus. Muaj cov neeg uas cov tshuaj no tsis tau pab los yog lawv tsis tau pom kiag li tsis muaj kev hloov nyob rau hauv kev noj qab nyob raws li txoj cai, lwm tus pib daig caj pas tom qab koj thov nws, muaj lub plawv palpitations. Nyob rau hauv lawv cov lus, Propafenone nws muaj peev xwm los cuam tshuam txog lub endocrine system cov tshuaj hormones nce. Yog li ntawd, ua ntej yuav noj no lam khoom yuav tsum tsis tau tsuas yog ua tib zoo nyeem cov lus qhia, tab sis kuj mloog mus rau lub indications, tshwm sim thiab contraindications.

Yog li, cov tshuaj yuav tsum tsis muaj ntaub ntawv yog hais tias muaj yog atrioventricular thaiv qib 2-3, nyob rau hauv cardiogenic poob siab, hyperthyroidism. Kev npaj "Amiodarone" yog tsis siv nyob rau hauv nws cov high rhiab heev rau lub active neeg sawv cev thiab iodo. Ban loj ua txhaum ntawm mob conduction thiab lub sijhawm uas nws bradycardia nrog syncope. Tsis txhob siv cov tshuaj thaum lub sij hawm cev xeeb tub thiab lactation. Lactation, thaum lub sij hawm lub sij hawm ntawm kev siv yeeb tshuaj kho mob yuav tsum tsis txhob pub niam mis.

tej tswv yim pom zoo

Yuav tsum tau ua tib zoo saib xyuas los ntawm ib tug kws kho mob kho kev kho mob tshuaj "Amiodarone". Cov lus qhia rau kev siv kom siv cov ntsiav tshuaj tom qab lub X-ray txoj kev tshawb no ntawm lub siab, lub ntsws thiab ntawm cov electrocardiogram. Tej xyuas yuav tsum tau nqa tawm nyob rau hauv lub neej yav tom ntej, yog hais tias tus neeg mob tseem noj cov tshuaj.

Cov heev kev phiv cov txheej xwm feem ntau yog nyob rau hauv lub koob, uas siv rau tus neeg mob. Yuav tsum sim siv cov tshuaj raws li ncaw li sai tau thiab nyob rau hauv qhov chaw cia ntau. Feem ntau ua rau cov lus plawv dhia tshem tawm "Amiodarone" tshuaj.

Cov lus qhia rau kev siv - xyuas hais tias, nyob rau hauv kev phem ntawm lub sab los, cov tshuaj no tau txais kev cawmdim ntau tshaj ib lub neej - hais tias lub pharmacological kev txiav txim ntawm cov tshuaj yog khaws cia rau lwm ob lub lis piam tom qab nws tso tseg.

Ntsiav tshuaj muaj iodine, uas muaj txhawb rau tsub zuj zuj theem ntawm radioiodine nyob rau hauv lub qog caj pas. Yog li ntawd, thaum pib ntawm lub tshuaj kho mob, thaum lub sij hawm thiab thaum kawg koj yuav tsum lossi tau soj ntsuam kuaj rau tus nqi ntawm cov thyroid hormones.

Thaum lub sij hawm kho cov kev pab yog tsim nyog yuav tsum tsis txhob ntev hnub raug, nws tsis yog tsim nyog los noj lub qhib hnub. Cov tshuaj yuav tsum tau muab nrog ceev faj rau cov neeg laus cov neeg uas muaj ua kom tsaug zog los yog thaum lub sij hawm lub chav kawm ntawm lub oxygen kev kho mob. Nrog ceev faj nws yuav tsum siv cov neeg tsav tsheb ntawm cov tsheb thiab cov neeg uas nws txoj hauj lwm yog txuam nrog ib tug concentration.

Nyob rau hauv tus neeg mob ntawm overdose tej zaum yuav muaj worsening ntawm sab los, raws li zoo raws li hypotension, arrhythmia. Tej zaum tshwm sim bradycardia los yog tsis ua hauj lwm ntawm AV conduction. Ib overabundance tej zaum yuav ua rau lub siab tsis ua hauj lwm.

Nyob rau hauv cov ntaub ntawv no, peb pom zoo kom tam sim ntawd pais plab lavage, sau tshuab txais hluav ncaig, saline tshuaj ntaus cev pom zoo cov ntsiab. Yog hais tias bradycardia tshuaj ntawm atropine, siv agonists ntawm beta-adrenergic receptors, ua lus sib laws liag.

Kev sib raug zoo nrog lwm yam tshuaj

Ceev faj yuav tsum raug siv yeeb tshuaj ib txhij nrog lwm yam tshuaj, tshwj xeeb tshaj yog yog hais tias lawv yog los ntawm cov tib pab pawg ntawm antiarrhythmic. Nws yog tsis tsim nyog mus ua ke nrog cov kev txais tos "erythromycin", "pentamidine" thiab "vincamine." Muaj yog ib tug uas yuav ntawm polymorphic ventricular tachycardia nyob rau hauv ua ke nrog nrog "sultopride". Nws tsis pom zoo kom muab kom tsawg CCB thiab beta-blockers nrog "Amphotericin B" thiab cov tshuaj uas ua rau ib tug laxative nyhuv, diuretic. Nrog kev saib xyuas siv cov tshuaj nyob rau hauv ua ke nrog nrog corticosteroids, antidepressants, "Astemizole", "terfenadine." Tau ho txhim khu cov teebmeem ntawm tej cov tshuaj raws li "warfarin", "Phenytoin" "Tacrolimus" los yog "Digoxin". Thaum siv nyob rau hauv ua ke nrog "cimetidine" slows tus txheej txheem ntawm metabolism hauv lub cev.

Lub neej thiab cia cov qauv

Lub medicament "Amiodarone", uas nws txiav txim yog hais rau tshem tawm ntawm tachycardia, ventricular fibrillation, tachyarrhythmia thiab atrial Flutter yuav txo tau, yog hais txog kev npaj qeb "B" pab pawg neeg. Txee-lub neej ntawm cov tshuaj yog tsawg tshaj li peb xyoo. Ntsiav tshuaj yuav tsum tau muab cia rau hauv ib lub txias, tsaus ntuj nti thiab tawm ntawm ncav cuag ntawm cov me nyuam.

kev siv cov "Amiodarone" tshuaj yuav tsum tau nruj me ntsis tiv thaiv tau. Lub daim ntawv qhia siv nws sau tawm ib tug kws kho mob. Nyob rau hauv cov ntaub ntawv no, nws tus kheej yuav tsum tau kiag li tshem tawm.

analogs medicament

Yog hais tias koj mam li nco dheev tsis haum cov tshuaj "Amiodarone" analogs yuav muaj nyob rau hauv tej chaw muag tshuaj. Ntawm lawv yog cov tshuaj xws li: "Amiodarone Belupo" thiab "Amiodarone Aldaron", "Angoron" thiab "Atlans" thiab hloov nws nrog tshuaj yuav "Kordaron" los yog "Kordinil". Zoo ib yam li "Amiodarone" nyob rau hauv nws cov teebmeem nyob rau hauv tib neeg lub cev "Medakoron" thiab "Palpitin". Nyob rau hauv tej rooj plaub, cov tshuaj yog hloov los ntawm "Sedakoronom" thiab "Sandoz".

Cov tshuaj yog muaj qhov tib active tshuaj los yog zoo nyob rau hauv lawv cov antiarrhythmic nyhuv ntawm cov tshuaj "Amiodarone". Analogues yog feem ntau ua txawv teb chaws thiab yog ob peb lub sij hawm ntau kim heev.

Testimonials

Muaj ntau cov neeg mob hais stabilization ntawm lawv tus mob tom qab noj cov tshuaj, "Amiodarone". Cov lus qhia rau kev siv - feem ntau cov tshuaj analogs raug xaiv raws li tus neeg cov yam ntxwv ntawm tus kab mob - cog lus rau normalize lub plawv dhia, siab. Thaum sib quas ntus txais tos nyob rau hauv me me koob tshuaj, feem ntau tsis muaj teeb meem, thiab cov tshuaj ua zoo.

Tom qab heev siv ntawm cov tshuaj nyob rau hauv ib co neeg mob nyob ua tsis taus pa, lub plawv palpitations, nervousness thiab kev nyuaj siab, mus ob peb vas ua viav vias thiab nce cov thyroid hormones, ib tug teeb meem ntawm tus mob huam, thiab nyob rau hauv tej rooj plaub, xeev siab thiab ntuav.

Heev muaj coob tus neeg siv nws nyob rau hauv cov kev kho mob ntawm angina, thiab nco ntsoov hais tias nws yog tsis muaj zuj zus tshaj mas counterparts. Ib txhia txiv neej yog ntshai mus coj cov tshuaj, vim hais tias nws yog nyob rau hauv lawv, nws muaj peev xwm mus ua ib tug xov tooj ntawm cov qog nqaij hlav. Nws yog ntseeg hais tias cov tshuaj yuav tsum tau noj xwb nyob rau hauv kev mob uas tawm tsam tib neeg lub neej, nyob rau hauv tag nrho cov lwm yam teeb meem, nws yuav tsum tau saib rau ib tug lwm txoj. Nyob rau hauv tas li ntawd, cov ntsiav tshuaj yuav muaj ib tug tsis zoo feem on txiv neej deev muaj nuj nqi, uas yog tseem yuav pom tau tias nyob rau ntawm lawv txais tos.

Txawm yog muaj ntau yam tshuaj "Amiodarone" nws yog ib tug panacea, ua tsaug rau uas tus kab mob no tau receded, tab sis tus txiv neej yuav ciaj sia. Tsis qhov tseeb hais tias analogues yuav yuav cia li zoo li. Yog li ntawd, nyob rau hauv cov kev kho mob ntawm kab mob plawv, tsis txhob txo cov tshuaj tawm, tshwj xeeb tshaj yog yog hais tias tus kws kho mob pom nws.