"Azithromycin" rau cov me nyuam: phau ntawv qhia, xyuas

Nyob rau hauv cov ntaub ntawv ntawm nyuab kab mob uas tsis tau lis penicillin raws li tshuaj tua kab mob, cov kws kho mob muab cov tshuaj "azithromycin". Rau cov me nyuam (cov lus qhia rau kev siv yog hais txog rau nws) cov tshuaj muaj ib tug heev muaj zog ua hauj lwm, nyob rau hauv tej rooj plaub, peev xwm cuam tshuam tsis tau tag nrho tsim kab mob, thiaj coj nws tsim nyog yam tsawg kawg nkaus koob tshuaj.

Tso daim ntawv thiab muaj pes tsawg leeg

Formulation muaj active tshuaj thiab koom haum pab cam azithromycin uas muab tsoos daim ntawv ntsiav tshuaj. Tsis tas li ntawd ua tsaug rau cov tshuaj yog absorbed zoo tshuaj.

Vim lub sab spectrum tshuaj tua kab mob siv ntau yam ntaub ntawv ntawm kev tso tawm ntawm cov tshuaj siv nyob rau hauv niaj hnub pharmacology:

• Hard gelatine tsiav tshuaj nrog ib tug xiav hau lub cev thiab xiav, hauv uas yog dawb los yog daj ntseg daj hmoov (los yog ib tug compacted loj). Thaum koj nias tus so. Lub tsiav tshuaj yog muaj nyob rau hauv tas li ntawd mus rau lub active ingredient, microcrystalline cellulose, sodium sulfate lauryl thiab magnesium stearate.
• "Azithromycin" (125) qhia rau kev siv rau cov me nyuam qhia txog raws li cov ntsiav tshuaj zaj duab xis loj nyob rau hauv xiav, ib tug yeej zoo lawm, biconcave. Nyob rau hauv ib tes lawv muaj ib tug engraving "PLIVA", nyob rau lwm yam - "125". Yog hais tias koj ua txhaum, koj yuav pom tias nyob rau ntawm lub lub lem ntawm cov tshuaj dawb. Nws muaj cov nram qab adjuvants: anhydrous calcium hydrogen phosphate, hypromellose, pob kws starch, microcrystalline cellulose, pregelatinized starch, sodium sulfate lauryl thiab magnesium stearate.
• Tshuaj "Azithromycin" rau cov me nyuam qhia ntawv nyob rau daim ntawv thov kom daim ntawv ntawm ib ncua kev kawm, li ntawd, cov chaw muag tshuaj yuav tau ib tug tshwj xeeb hmoov rau nws cov kev npaj nrog ib tug txiv los yog txiv tsawb tsis hnov tsw.

Tus nqi ntawm cov tshuaj tua kab mob yuav tsub kom nyob rau hauv cov ntsiab lus ntawm active tshuaj.

pharmacological yam ntxwv

"Azithromycin" yog hais txog mus rau lub broad-spectrum tshuaj tua kab mob. Thaum END nyob rau hauv qhov kev tsom xam ntawm o tshwm sim txoj kev tuag ntawm microorganisms.

Feem ntau cov sensitive mus rau yeeb tshuaj gram-zoo cocci: tus kab mob Streptococcus pneumoniae, tus kab mob Streptococcus pawg CF thiab G, Staphylococcus aureus, St. Pyogenes, St. Viridans, St. agalactiae; Gram-tsis zoo kab mob: Moraxella catarrhalis, H. Ducrei, Haemophilus influenzae, Legionella pneumophila, Bordetella pertussis, Neisseria gonorrhoeae, B. Parapertussis, Gardnerella vaginalis thiab Campylobacter jejuni; co kab mob: Chlamydia trachomatis, Bacteroides bivius, Ureaplasma urealyticum, Peptostreptococcus spp, Clostridium perfringens, Borrelia burgdoferi, Treponema pallidum, thiab Mycoplasma pneumoniae. Gram-zoo kab mob resistant rau erythromycin, ib tug tshuaj tua kab mob yog hloov dua siab tshiab rau ib tug tsaug zog daim ntawv.

tshuaj

"Azithromycin" rau cov me nyuam (cov lus qhia rau kev siv yog hais txog rau nws) yog sai absorbed los ntawm tus mob huam vim kuj mus acidic nruab nrab thiab lipophilicity. Sai faib thoob plaws hauv lub cev. Yooj yim nws penetrates tsis tsuas mus rau hauv lub ntsws huam, nqaij mos thiab tawv nqaij, tab sis kuj mus rau lub nruab nrog cev ntawm lub urogenital ib ntsuj av. Raws li ib tug tshwm sim, ib tug tsis tshua muaj losis tswvyim dabtsi ntawm azithromycin thiab ntshiab cov nqaijrog, allergic muaj peev xwm mus rau hauv eukaryotic hlwb thiab concentration nyob rau hauv nruab nrab nrog cov uas tsis muaj pH, tej lysosomes nce ntev ib nrab-lub neej thiab concentration nyob rau hauv ntaub so ntswg.

Tag nrho cov no txiav txim lub siab tshaj plaws volume ntawm tis (31.1 litres ib kg) thiab siab ntshav clearance. Rau cov kev puas tsuaj ntawm intracellular pathogens ntawm loj tseem ceeb yog cov muaj peev xwm mus "Azithromycin" noog ncaj qha nyob rau hauv lub lysosomes.

Vim phagocytes tshuaj twg thiaj li raug rau lub site ntawm tus kab mob, qhov chaw uas nws tso tawm nyob rau hauv tus txheej txheem ntawm phagocytosis. Tom qab 12-72 teev ntawm kev noj nyob rau hauv qhov kev tsom xam ntawm o yog tiav los ntawm lub high school lub concentration ntawm cov tshuaj, uas yog ho siab tshaj qhov tsawg kawg nkaus inhibitory concentration rau tus kab mob ntawm pathogens.

Raws li twb tau hais, ib nrab-lub neej ntev, yog li, piv txwv li, yuav tsum tau 60 mus rau 76 xuab moos mus rau tshem tawm cov los ntawm fabrics. Bactericidal concentration ntawm cov tshuaj yog muab cia rau hauv qhov chaw ntawm o rau 5-7 hnub tom qab kawg koob, li ntawd, nws yog tej zaum yuav siv ib zaug xwb tshuaj tua kab mob nyob rau hauv lub hnub, lub chav kawm ntawm kev kho mob yog tsis ntau tshaj li ib lub lim tiam.

Qhia "Azithromycin" feem ntau nyob rau hauv cov kua tsib, thiab tsuas yog ib tug me me feem - thaum tso zis.

Indications rau kev txais neeg kawm

"Azithromycin" cov lus qhia rau kev siv ntawm cov me nyuam yog xav kom nominate nyob rau hauv kab thiab inflammatory kab mob, uas yog txhais los ntawm cov kab mob raug rau azithromycin. Tej kab mob muaj xws li: mob ntsws, ntsws, sinusitis, pharyngitis, nqaij mos thiab tawv nqaij kab mob, tonsillitis, otitis media, Lyme kab mob thiab urethritis. Rau xav tias mob ntsws muaj dej pediatricians yuav tam sim ntawd muab tshuaj tua kab mob, txawm tsis muaj tus tau ntawm X-ray xeem. Kev kho mob ntawm tus kab mob no yuav tsum tau pib nyob rau hauv lub sij hawm zoo, txwv tsis pub koj yuav raug rau feem ntau cov tsis muaj hmoo txim. Cov tshuaj tua kab mob nyob rau hauv xws li ib tug cov ntaub ntawv yog xaiv kev noj mus rau hauv tus account tag nrho cov tsos mob, cov liam yav thiab tus soj ntsuam daim duab raws li ib tug tag nrho. Nyob rau hauv kev txiav txim tau tus kab mob ua rau tus kab mob, lub hnub nyoog ntawm cov me nyuam yog muab rau tus account. Yog hais tias mob ntsws muaj dej yog xav tias nyob rau hauv ib tug me nyuam hnub nyoog 1 txog 6 lub hlis, ces. feem ntau yuav, tus neeg saib xyuas - ntawm Staphylococcus aureus, los ntawm ib lub xyoo mus rau xyoo - tus kab mob Streptococcus pneumoniae. Nrog ob hom kab mob zoo fights "Azithromycin".

dosing

Cov kev kho mob regimen yuav nyob ntawm seb tus kab mob, tab sis tag nrho cov koob tshuaj yuav tsum tau khaws cia. Tus kws kho mob yuav muab tshuaj rau cov tshuaj "Azithromycin" rau cov me nyuam. Cov lus qhia rau kev siv tso cai cov ntsiav tshuaj rau noj xwb laus vim lawv muaj 250 mus rau 500 mg ntawm active tshuaj, thiab tus nqi no yog xam rau ib tug es loj loj. Qhov tseeb hais tias cov ntsiav tshuaj yuav tsum tau nqos tag nrho, yog tsis pom zoo kom zuaj los yog zom thiaj li thiaj li yuav tsis muaj cov pom zoo npaum ntawm ib tug ib-lub sij hawm siv (10 mg / kg). Nws yog vim li no cov hluas li antibacterial cov neeg ua hauj muab "Azithromycin" (125). Cov lus qhia rau kev siv rau cov me nyuam ntsiav tshuaj txwv tsis pub noj txog 12 xyoo, lawv yuav tsum tau hloov nrog ib tug phoov los yog ib ncua kev kawm.

Rau cov kev kho mob ntawm mob inflammatory caj pas kab mob, otitis, mob ntsws tsa ib koob tshuaj tshuaj (10 mg / kg). Tshuaj "Azithromycin" (125) qhia rau kev siv rau cov me nyuam nyob rau hauv cov ntsiav tshuaj xav tias tsuas yog tom qab ncav 14 xyoo ntawm lub hnub nyoog. Kev kho mob Cov me nyuam ua heev dua lwm yam uas siv cov kev slurry.

Nws yuav tsum tau hais tias nyob rau hauv 5 grams ntawm phoov "Sumamed" (me nyuam diav) thiab lwm yam analogs formulation kuj muaj 125 mg ntawm active tshuaj. Raws li, qhov standard koob tshuaj rau cov laus dua cov me nyuam yog 1-2 dia, nyob ntawm seb qhov hnyav. Thaum lub sij hawm nram qab no plaub hnub ntawm kev kho mob ntxiv, tab sis nyob rau tib lub npaum yog txo mus rau 5 mg / kg. Nyob rau hauv cov ntaub ntawv ntawm hnyav koob tshuaj tej zaum yuav ob npaug, tab sis nyob rau hauv xws li ib tug teeb meem no, siv cov tshuaj tua kab mob yog permissible xwb nyob rau hauv lub saib xyuas ntawm ib tug tshwj xeeb. Kev npaj "Azithromycin" (125) qhia rau kev siv rau cov me nyuam tej zaum yuav tsuas yog siv nyob rau hauv cov ntaub ntawv uas tau txais ib tug ib zaug los yog ob zaug nyob rau hauv ib tug ntau npaum ntawm 30 mg / kg lub cev hnyav.

Contraindications

Tshuaj "Azithromycin" rau cov me nyuam phau ntawv qhia txwv tsis pub nyhav tshaj tsib kilograms. Nyob rau hauv tas li ntawd, nws yog ua rau cov neeg mob uas npau taws me ntsis rau lub Cheebtsam muaj nyob rau hauv muaj pes tsawg leeg mus rau lwm yam macrolide tshuaj tua kab mob. Qhov no tshuaj yog nyob rau hauv txhua rooj plaub yuav tsum tsis txhob muab siv nyob rau hauv mob loj heev siab thiab raum tsis ua hauj lwm.

Overdose thiab kev phiv

Rau cov neeg niam uas yog siv cov tshuaj "Azithromycin" rau cov me nyuam, cov lus qhia rau kev siv (neeg mob testimonials hais txog kev siv ntawm tshuaj tua kab mob nyob rau hauv no cov ntaub ntawv uas) muab ib daim ntawv teev kev phiv. Nyob rau hauv ib feem ntawm lub lymphatic system thiab cov ntshav tsim yuav tsim trombotsipenii.

Cov neeg mob manifest Aggressiveness, hyperactivity, nervousness thiab ntxhov siab vim. Los ntawm lub paj hlwb Kiv taub hau, convulsions, mob taub hau, somnolence, thiab txawm tsaus muag. Nyob rau hauv tsawg tus neeg mob, cov tshuaj ua sleeplessness, qaug zog, paresthesias, cuam tshuam xaav ntawm tsw thiab saj.

Ncaw macrolides (pab pawg neeg ntawm cov tshuaj, lub hauv paus ntawm cov tshuaj qauv ntawm uas protrude macrocyclic 14- los yog 16-membered lactone nplhaib nrog cov txuas carbohydrate residues), thiab uas belongs rau "azithromycin" ua rau tsis hnov lus. Feem ntau yeej tsis, tab sis tseem muaj tshwm sim los ntawm dyspeptic cim thiab manifest tsis haum.

"Azithromycin" qhia ntawv nyob rau daim ntawv tso cai cov me nyuam mus siv, tiam sis cov me nyuam cov tshuaj yuav tsum tau noj xwb nyob rau hauv daim ntawv ntawm ib ncua kev kawm. Rau cov laus dua cov me nyuam haum thiab capsule daim ntawv ntawm cov tshuaj tua kab mob. Ua ntej thov kev cov tshuaj, koj yuav tsum tau ib tug kws kho mob tso cai thiab nyeem cov pob insert cov lus qhia kom zoo zoo.

Hais txog overdose tej zaum yuav qhia raws plab, ib ntus tsis hnov lus, xeev siab thiab ntuav. Nyob rau hauv cov ntaub ntawv ntawm tau siab tshaj lub pom zoo koob tshuaj yuav tsum tam sim ntawd rinsed plab, ces npaj mus rau symptomatic txoj kev kho.

ceev faj

Txoj kev siv "Azithromycin" thaum lub sij hawm cev xeeb tub yog tsis tshua muaj undesirable, tab sis tau yog hais tias tsis yooj yim sua kom siv nws los pab tus poj niam (tshuaj ntxim rau cov me nyuam hauv plab kev loj hlob nyob rau ntawm 100% twb tsis tau kawm). Lub lactation lub sij hawm thaum siv tau nyob rau lub sij hawm ntawm tshuaj tua kab mob kev kho mob rau cuam tshuam kev pub niam mis.

Cov me nyuam nyob rau hauv 12 lub xyoos yog zoo dua mus xaiv ib tug analog "Azithromycin".

Haus dej haus cawv tsis cuam tshuam rau kev txiav txim ntawm cov tshuaj, txawm li cas los nws siv yog compounded rau tej yam kab mob. Yog li ntawd, tus nqi ntawm cov ntim cawv yog pom zoo kom txo tau kom lub siab tshaj plaws, thiab txawm zoo dua muab rau cov kev kho mob kiag li.

tshuaj cov kev sib tshuam

Thaum tau txais cov "Azithromycin" nrog rau cov antacids uas muaj calcium, magnesium thiab txhuas, nws slows qhov haum ntawm lub tshuaj tua kab mob, yog li ntawd, tsim nyog mus soj ntsuam cov 2-teev luv ntawm koob tshuaj ntawm cov tshuaj.

Lub ntsiab sib txawv ntawm cov tshuaj no mus rau lwm cov macrolide tshuaj tua kab mob - tsis muaj kev sib txuas lus nrog rau cov cytochrome system. Yog li ntawd, thaum noj nrog "theophylline", "carbamazepine", "Digoxin", "terfenadine" thiab "triazolam" muaj tsis muaj kev sis raug zoo.

Yog hais tias cov tshuaj yog siv nrog "warfarin", nws yog tsim nyog los saib xyuas cov prothrombin lub sij hawm.

Lincosamides txo cov hauj lwm zoo ntawm cov tshuaj tua kab mob thiab chloramphenicol thiab tetracycline nce.

Tej yam kev mob thiab cov nqe lus

Cov tshuaj tua kab mob yuav tsum tau muab cia rau hauv ncav tsis cuag ntawm cov me nyuam ntawm ib tug kub mus txog 25 degrees. Nyob rau hauv txee lub neej ntawm cov pov thawj muaj rau cov tshuaj "Azithromycin" (rau cov me nyuam), phau ntawv qhia. Lub ncua kev kawm ntawv npaj yuav khaws cia rau tsis muaj ntau tshaj 5 hnub, cov hmoov nws tus kheej - 2 xyoos, thiab cov ntsiav tshuaj thiab tsiav tshuaj - txog li 3 xyoos.

Analogs thiab cov tswvyim ntawm cov neeg mob

Cov neeg uas siv lub "Azithromycin" rau cov me nyuam (cov lus qhia rau kev siv cov tshuaj yog tsis pom zoo kom coj nyob rau hauv cov me nyuam), sab laug feem ntau zoo xyuas. Tom qab thawj koob tshuaj ntawm cov tshuaj tua kab mob raug rho tawm ntau yam pauv loj txoj kev txhim kho, cov neeg kawm txoj ntxiv.

Los ntawm analogues ntawm cov tshuaj muaj xws li "Azitsin", "Zomax," "Sumamed", "Azitral", "Azaks", "Zitroks" thiab lwm tus neeg.