Yog vim li cas, pathogenesis thiab cov tsos mob ntawm gout

Nyob rau hauv ib pab pawg neeg ntawm rheumatic kab mob muaj xws li thiaj li hu ua microcrystalline los yog metabolic mob caj dab. Ib tug ntawm cov yog gout mob caj dab, cov tsos mob thiab ces cov neeg uas twb paub txij li thaum Hippocrates. Tus kab mob no tshwm sim vim impaired metabolism ntawm uric acid rau nws cov high cov ntsiab lus nyob rau hauv cov ntshav, raws li zoo raws li pathological deposition ntawm muaju (urate) nyob rau hauv cov ntaub so ntswg. Yog li ntawd gout cov tsos mob clinically manifest tshwm sim ntawm mob mob caj dab, thiab tsim ntawm tophi, gouty tej ntshav.

Greeks muab lub npe ntawm tus kab mob no. Tus thawj lub npe hu mus rau hnub tim, ib tug piav qhia ntawm tus kab mob muab lub Greek tus kws kho mob Saranus. Qhov no kev mob nkees raug kev txom nyem hauv Makadaunias, Newton thiab ntau lwm yam zoo-paub cov keeb kwm cov nuj nqis.

Tus xov tooj ntawm cov neeg uas nrhiav tau lawv tus kheej gout cov tsos mob txhua txhua xyoo tsub kom. Tiamsis, nws yog muaj peev xwm yuav ntaus nqi mus rau paub muaj lub neej zoo thiab lub hwj chim. Tsis muaj zem hais tias tus kab mob no yog hu ua "tus kab mob ntawm aristocrats."

Qhov teeb meem ntawm tus kab mob no yog nws lig mob, feem ntau twb nyob rau hauv lub mob nyob ntev, thaum tus kab mob no cov txheej txheem yog tsis tsuas cov pob qij txha muab kev koom tes.

Cov thawj cov cim qhia ntawm gout feem ntau pib los cuam tshuam hauv nruab nrab-hnub nyoog txiv neej. Tab sis tus kab mob no yog npaum li cas "rejuvenated" lately. Nws muaj peev xwm yuav nrhiav tau nyob rau hauv peb caug tub ntxhais hluas. Rau feem ntau ntawm nrhiav kev pab gout nres pib nrog lub tsos ntawm kev mob thiab o thawj (loj) ntiv taw xoo. Qhov no yog qhov classic version. Tus so cim mob nyob rau hauv lwm yam pob qij txha ntawm tus taw, raws li zoo raws li nyob rau hauv lub loj pob qij txha ntawm lub nqua.

Yuav kom nkag siab txog cov pathogenesis ntawm tus kab mob, koj yuav tsum muaj kev to taub ntawm lub cev metabolism ntawm uric acid. Nyob rau hauv tib neeg, nws yog ib lub txiaj ntsim ntawm lub splitting ntawm purines. Nyob rau hauv peb kab mob qhov chaw txoj kev xws acids uas yog noj tiv tauj cov khoom noj uas muaj purines (nqaij, legumes, caw liab, ntses, thiab lwm yam), Nucleoproteins hlwb. Tas uric acid yog tso zis los ntawm cov hnyuv nqis hnyuv muaj, thiab zis (nws cov ntsiab ib feem).

Cov ua rau tus kab mob

Nws yog lub npe hu hais tias muaj cov tsos mob ntawm gout ntawm combining ib tug dhau heev lawm ntawm uric acid nyob rau hauv lub cev thiab txo nws feem nyob rau hauv cov zis. Ua lub acid tsim tej zaum yuav vim ntau tau ntawm Noj cov khoom noj purines thiab ntau dua, lub puab synthesis ntawm purines nyob rau hauv lub cev.

Faib ib tug thawj thiab ib tug thib ob hyperuricemia. Gout yog lub txiaj ntsim ntawm tus thawj embodiment. Secondary nce ntawm uric acid nyob rau hauv cov ntshav feem ntau yog ib tug txim ntawm lub raum tsis ua hauj lwm, ntau yam myeloma, tej hom ntawm leukemia thiab anemia, thiab tseem manifested nyob rau hauv daim ntawv thov ntawm tej yam kev kho mob preparations, piv txwv li, diuretics.

Ib tug dhau heev lawm ntawm acid nyob rau hauv cov ntshav ua rau nws deposition nyob rau hauv nruab nrog cev thiab cov nqaij. Nyob rau hauv daim ntawv ntawm sodium urate yog tso nyob rau hauv lub bursa penetrates mus rau hauv lub synovial cov kua. Urata txeem mus rau hauv lub pob txha mos, ua rau o thiab puas nws.

tsos mob ntawm gout

Raws li sau tseg saum toj no, ib tug classic version yog ib tug sib koom tus kab mob ntawm tus ntiv taw xoo. Los ntawm nws tus kheej, ib tug dhau heev lawm ntawm uric acid nyob rau hauv lub cev tsis tshwm tsos mob, thiab thim mloog mus rau cov yeej ntawm no xyov ob leeg. Feem ntau mas txhais los ntawm overeating, hypothermia, kev poob plig los yog kab mob. Feem ntau kev mob caj dab nres tshwm sim tiv thaiv ib tug tom qab ntawm tag nrho zoo, txawm hais tias tej zaum cim cov tsos mob-precursors xws li nquag hloov ntawm mus ob peb vas, ntev li txob taus, etc.

Feem ntau mob tshwm sim thaum hmo ntuj thiab mam li nco dheev. Tus mob no thiaj li mob loj heev hais tias nws yog tsis yooj yim sua mus kov tus txha. Nyob rau tib lub sij hawm no muaj o thiab liab. Tom qab ib los yog ob hnub, qhov mob ploj. Ib tug yam ntxwv feature ntawm arthritic mob yog nws cia li thiab ceev pib thiab ib tug cia li kawg. Yog hais tias loj pob qij txha yog cuam tshuam, tus soj ntsuam daim duab yog reminiscent ntawm phlegmon. Cov pob qij txha peev xwm yuav tsim tophi. Lawv yog cov ua pob pov tseg nyob rau hauv daim tawv nqaij los yog nyob rau hauv cov pob qij txha (urate deposits). Cov ntshav theem ntawm uric acid.

kev kho mob

Nyob rau hauv mob nres siv colchicine, anti-inflammatory, analgesic tshuaj (narcotics yuav muab). Nws yog ib qho tseem ceeb noj cov khoom noj nrog rau cov kev zam ntawm ib tug noj haus ntawm cov nqaij, haus dej cawv byproducts.

Cov kauj ruam thib ob yog lub sij hawm ntawm cov tshuaj uas txo lub cev zus tau tej cov uric acid. Yog li cov tshuaj yog allopurinol los yog nws analogs. Qhov no tshuaj yog siv rau tas mus li thiab ntev-lub sij hawm kev kho mob ..