"Epoetin Alfa": phau ntawv qhia, kev xyuas thiab analogues

Uncharacteristic theem ntawm concentration ntawm hemoglobin - ib qho ntawm cov tsos mob ntawm anemia. Nyob rau hauv qhov tseeb, qhov no yog tsis yog ib tug mob, tiam sis tsuas yog cov tsos mob uas yog lub hallmark ntawm ntau cov kab mob. Cov kev kawm ntawm tej kab mob tej zaum yuav qhia ib tug thawj lesion ntawm cov ntshav system.

Lub stimulator ntawm erythropoiesis, lub npe hu nyob rau hauv lub thoob ntiaj teb uas tsis yog-tus qauv lub npe raws li "Epoetin Alfa" cov lus qhia rau kev siv raws li ib tug muaj kev kawm siab tso reagent pharmacological khoom no ncaj qha mus rau cov kev kho mob thiab kev tiv thaiv ntawm anemias ntawm txawv etiologies. Kom xaiv ntau npaum no tsis tsuas pab tswj cov ntshav tivthaiv qauv, tab sis kuj muaj ib tug zoo ntxim rau cov leeg plawv.

Tso daim ntawv thiab tshuaj muaj pes tsawg leeg

Lub lam cov khoom no yog muaj nyob rau hauv cov khw nyob rau hauv daim ntawv ntawm:

• muaj menyuam tsis taus pov tseg koob txhaj nrog ib tug preset koob tshuaj (tsim muaj rau ntxiv tiv thaiv koob);
• daws nyob rau hauv vials.

Lub luag hauj lwm ntawm lub koom haum pab muaj yog muab:

• injectable dej;
• chloride dihydrate thiab sodium hydrogenphosphate;
• polysorbate-80.

Lub lom ua si ntawm lub substance nyob rau hauv lub raj mis yuav ua tau txawv. Nyob rau hauv Feem ntau, ib txhiab los yog ob txhiab International Chav ib 0.5 ml ntawm cov kua. Txawm li cas los, tseem muaj muag lwm yam ntaub ntawv reagent, xws li "epoetin Alfa" 10,000 pcs. / 1 ml.

Lub mechanism ntawm pharmacological txiav txim

Lom thiab immunological thaj chaw ntawm lub tsim khoom yog zoo tib yam rau tej yam ntuj tso erythropoietin. Yog li ntawd, cov tshuaj zoo heev suppresses cov tsos mob ntawm anemia, thiab kho cov ntshav raws li ib tug raug glycoprotein. Kuv yuav tsum hais tias "epoetin Alfa" feem ntau aimed ntawm ua hematocrit thiab hemoglobin theem normalization. Nws "lub plawv muaj nuj nqi," raws li tau zoo raws li lub nyiam ntawm lub Cheebtsam los txhim kho cov ntshav txaus rau cov ntaub so ntswg yog tsawg pronounced.

ib nrab-lub sij hawm:

• los ntawm tso dej txhaj tshuaj - plaub teev
• thaum txhaj subcutaneously nrog - hais txog ib hnub twg.

Qhov siab tshaj plaws concentration ntawm ib tug reactant nyob rau hauv cov ntshav yuav muab tau leej tom qab 12-18 teev.

pharmacokinetic nuances

Kev tshawb fawb tau qhia tias cov piav tshuaj induces lub tsim ntawm cov tshuaj nyob rau hauv lub "dormant" hom, thiab nws pharmacological tseem ceeb nyob rau hauv cov txheej txheem ntawm hloov hlwb pob txha fibrosis yog nyob ze rau zero. Lub protein feem medicament "Epoetin Alfa" muaj txog 165 amino acids (58% ntawm tag nrho cov molecular nyhav), thiab qhov no yog thaws rov los nyob rau hauv lub degree thiab tsis zoo ntawm lub Cheebtsam feem xyuam rau txoj kev faib / ntau yam ntawm progenitor hlwb.

Ua tso dej thawj coj (nyob rau hauv qhov qhaj ntawv los ntawm lub raum pathologies) tsis ua rau tsub zuj zuj ntawm cov active tshuaj; cov me nyuam nyob rau hauv lub hnub nyoog ntawm 12 xyoo yog yuav prolongation ntawm T1 / 2 sij hawm mus txog 6 teev.

indications rau

"Epoetin Alfa" yog pom zoo rau cov kev siv yog hais tias:

• anemia thiaj paub hais tias raws li ib tug teeb meem ntawm hematopoietic muaj nuj nqi, uas accompanies cancer (muab qhov chaw yuav tsis-myeloid hlav);
• tus neeg mob hnov qhov yuav tsum tau rau li niaj zaus hemodialysis los yog peritoneal lim ntshav ;
• yog ib lo lus nug ntawm nqa tawm txoj kev phais uas siv cov allogeneic ntshav;
• tus neeg mob tus kab mob nrog tus kab mob HIV thiab tau txais txoj kev kho rau lub hauv paus ntawm zidovudine;
• Tw yuav tsum tau kev tiv thaiv.

Lub pom dosing regimen

Rau kev npaj "Epoetin Alfa", cov mis rau ib tug neeg xaiv ntawm lub hnub koob tshuaj. Txawm li cas los, cov kev pom zoo ntawm cov chaw tsim tshuaj paus yog tas rau tej kev cai thiab cov txheej txheem:

• thaum pib kho theem tsib caug txiav txim units (IU) ib kilogram lub cev hnyav, tab sis tsis muaj ntau tshaj peb tib / infusions ib lub lim tiam;
• nyob rau hauv lub qhaj ntawv ntawm pom ua haujlwm: 75 units / kg nyob rau tib lub caij nyoog, tab sis tsis muaj ntxov tshaj ib lub hlis tom qab pib ntawm kev kho mob;
• nyob rau hauv lub exceptional teeb meem no: 100-200 U / kg, nruj me ntsis adhering rau hais tias kev txhaj tshuaj lub sij hawm (kauj ruam nce - 25 units / hlis);
• txij nkawm txoj kev kho: koob tshuaj muab nyob rau tus nqi uas yog nyob rau hauv lub hematocrit ntau yam ntawm 30-35 vol. %.

Raws li kev xyaum qhia, rau qhov "txheem" feem ntau yog coj tib tus nqi ntawm 30-100 IU / kg, uas yog feem ntau tsav ntawm tus kawg ntawm lim ntshav. Lub pom ntev ntawm kuv / v Txoj kev lis ntshav - ib mus rau ob feeb; mechanism rau subcutaneous me nyuam ntawm cov active tshuaj raws li cov cai.

Classification tau phiv los

Nyob rau scenarios atypical kab lub tshuaj tiv thaiv rau lub xub ntiag ntawm lub tshuaj Cheebtsam "Epoetin Alfa" phau ntawv qhia ceeb toom txog cov nram qab no:

• tau mus pom cov tsos mob hais rau kab mob khaub thuas tus kab mob - mob loj heev kiv taub hau, kev nyuaj siab, tsis muaj zog, ua npaws, mob mob tej pob txha / nqaij;
• tso cai rau imbalances ntawm lub plawv thiab cov hlab ntsha - ib tug ntse nce nyob rau hauv cov ntshav siab, malignant tawg;
• ib tug yuav tsis quav ntsej txoj kev pheej hmoo ntawm thrombocytosis (tus kab mob no, tab sis nws muaj ib cov nyhuv yog tsis tshua muaj tsis tshua muaj, tab sis yog fraught nrog loj mob);
• reagent nyob rau hauv urinary system yog muaj peev xwm los txhawb los ntawm kev hloov tus nqi ntawm cov poov tshuaj thiab phosphate nyob rau hauv lub cev (tsis raug ntiab tawm creatinine theem nce rau hauv cov ntshav ntshav).

Nyob rau hauv daim tawv nqaij yog tej thaum kuj hnov voos txhais los ntawm cov kev taw qhia ntawm "Epoetin Alfa" kev npaj. Cov lus qhia, nyob rau hauv particular, hais lus ntawm ua pob ua xyua, eczema, angioedema. Thiab yog dab tsi interesting: thaum subcutaneous txhaj feem pua heev yog ntau dua: nyob rau nruab nrab ib txhiab tus neeg mob, ris rau txog 4 lub sijhawm uas nws (nrog rau / nyob rau hauv infusions - 1.6 xwb).

Nyob rau lub cev cov kev hloov uas yuav ua rau hais tias yeeb tshuaj, tsis muaj txhim khu kev qha ntaub ntawv (noteworthy tsuas hais tias cov yav tas los hais muaj peev xwm ntawm cov tshuaj induce tus tsim ntawm cov tshuaj).

Raws li cov chaw tsim tshuaj paus contraindications

Raws li cov ntaub ntawv muaj nyob rau hauv lub official daim ntawv qhia, "Epoetin Alfa" (analogs xws li "Binokrit" thiab "Eralfon" nyob rau hauv no hwm raws li nyob ze rau tus thawj) yuav tsum tsis txhob siv yog hais tias:

• mob uncontrolled tawg;
• tus neeg mob muaj kev npau taws me ntsis rau cov khoom xyaw;
• Yam ua ntej tsom xam pom ib tug tseem ceeb heev pathologies ntshav kab;
• tus neeg mob raug kev txom nyem ib lub plawv nres (peb yuav sib tham txog tsis ntev los no yav dhau los);
• muaj yog vim li cas mus ntseeg tau hais tias cov kev cuam tshuam ntawm tej ntshav txaus nyob rau hauv lub hlwb.

Nyob rau hauv lwm yam lus, pib ntawm txoj kev kho yuav tsum tau preceded los ntawm ib tug kws kho mob soj ntsuam.

ceev faj

"Epoetin alpha" (tradename structurally zoo tib yam formulation tej zaum yuav txawv - piv txwv li, raws li ib tug hloov yuav muab analogs "Aeprin", "Repoetin-SP", "Epokomb", "Eprex", etc ...) Yuav tsum tau siv nrog nce ceev faj tiv thaiv cov neeg txom nyem los ntawm recurrent / mob mob ntawm lub peripheral leeg. Qhov no txoj cai yog tshwj xeeb tshaj yog muaj tseeb yog tias ib tug keeb kwm raws li ib lo lus teb ntawm lub cev mus rau lub txais tos ntawm tej yam tshuaj twb kaw lub sijhawm uas nws convulsive tshua.

Nws tsis cuam tshuam nrog cov vigilance thiab rau gout. Accents thawj zaug yuav tsum mus rau qhov chaw nyob rau hauv cov teeb meem muaj feem xyuam rau cov ntshav siab thiab qhov tshwm sim ntawm mob taub hau (antihypertensives - ib qho ntawm cov hauv qab no kev kho mob kawg kho). Txawm li cas los, nws yog Attendance tseem ceeb los ntsuam xyuas thiab qhov tseeb lub xeev ntawm hlau khw muag khoom noj (ua ntej kev tshuaj). Thaum nqa tawm txaus ua ub no tsis reflected nyob rau hauv cov nqe lus ntawm cov ntshav siab, cov txheej txheem tau piav pharmacological khoom nres.

Peb yuav tsum nco ntsoov hais tias lub raum tsis ua hauj lwm, mob cancer thiab kab mob HIV nyob hauv daim ntawv ntawm cov kab mob nyob rau hauv lub chav kawm ntawm uas, tiv thaiv lub keeb kwm ntawm lub hematocrit concentration, muaj ib tug yam ntxwv txo nyob rau hauv ferritin theem nyob rau hauv cov ntshav ntshav. Yuav kom mitigate imbalances resort rau hloov kho uas Fe-muaj reactants.

Kuaj rau hemoglobin nws yog advisable mus noj 1 lub sij hawm txhua txhua 7 hnub. Tsis tas li ntawd thaum lub sij hawm lub community launch txog ob lub hlis yuav tsum tsis tu ncua saib xyuas ntawm platelet suav. Thiab rau 5-10 hnub ua ntej rau kev phais, ib tug neeg mob yog muab tshuaj card tshuaj muaj antithrombotic zog.

Cov chaw tsim tshuaj paus tsis kav tawm hais tias cov Cheebtsam ntawm cov tshuaj yuav ua rau tej hom hlav, yog li kev soj xyuas tus neeg mob yuav tsum tsis txhob tso tseg txawm los ntawm tus kawg ntawm lub active kev kho mob theem.

Yuav ua li cas nyob rau hauv cov ntaub ntawv ntawm ib tug overdose?

"Epoetin alpha" (txhais-tshuaj, incidentally, ua nyob rau hauv ib tug zoo li yam) nrog ib tug overdose ua raws li cov algorithms siv nyob rau hauv lub tshuaj mis ntawm kev siv erythropoietin i.e. provokes polycythemia hematocrit theem thiab oscillations. Vim cov tsis muaj classic Antidotes, ib co tshwj xeeb kev ntsuas rau deactivation ntawm cov khoom xyaw yog tsis nqa tawm - cia li muab tso tseg lwm lub sij hawm noj tshuaj.

Txhob txwm bloodletting siv nyob rau hauv tus neeg mob ntawm thaum muaj xwm ceev, thaum ib tug tshaj-txwv qhia ntawm hemoglobin qhia ib tug tiag tiag kev hem thawj rau lub neej.

Sib tshuam nrog Tshuaj

Nyob rau hauv kev multi-theem complex txoj kev kho yog tsis tshua muaj ib qho tseem ceeb kom nkag siab txog lub hauv paus ntsiab lus ntawm "pharmacological tus cwj pwm" "Epoetin Alfa" reagent (tso tawm daim ntawv no, raws li tau piav saum toj no, yuav tau sib txawv, tab sis hauv lub mechanism ntawm no biochemical cov tshuaj tiv thaiv tsis hloov).

Yog li, nyob rau hauv particular, thaum uas tig mus kev taw qhia ntawm cov ntshav cov khoom muaj ib tug zoo ntxim rau cov kev txhim kho lub puab. Tiam sis peb yuav tsum nco ntsoov hais tias tus dilution ntawm ib tug tov ntawm lwm yog inadmissible. Cov tshuaj yog "union" cyclosporin fraught nrog zuj zus lawm concentration ntawm lub yav tas (cov optimum volumetric piv ntawm cov koob tshuaj yog txiav txim empirically).

Comments

Analysis ntawm lub views qhia tau hais tias qhov loj tshaj plaws pes tsawg tus ntawm cov lus nug tshwm sim thaum uas nws los txog rau cov kev xaiv uas muaj rau kev daws qhov teeb meem qub. Piv txwv li, ob peb ntawm cov neeg mob versed nyob rau hauv qhov sib txawv uas noj qhov chaw ntawm xws pharmacological cov khoom, xws li "epoetin Alfa" thiab "epoetin beta."

Yuav ua li cas yog qhov txawv - yooj yim rau to taub, yog hais tias peb mloog cov lus ntawm cov kws kho mob. Lub fact tias cov yam ntxwv qauv ntawm tej yam ntuj tso erythropoietin yog sawv cev los ntawm ob chains, nrog lub Desired ntxim rau cov ntshav system muaj ob. Manufacturers tib tshuaj, vim hais tias ntawm qhov sib txawv nyob rau hauv technology, los yog los ua ke alpha-fragment los yog beta.

Raws li rau cov lus nyob rau hauv cov kev npaj nws tus kheej, muaj ntau yam ntawm cov neeg uas yuav tsum tau sim rau koj tus kheej, qhia tau tias nws txhais tau tias nws yog heev zoo, thiab nyob rau hauv ib co tshwj xeeb no thiab nyob tag nrho indispensable rau tej pawg ntawm cov neeg mob.