Analogue ntawm Plavix.

Ib tug ntawm ua ke antiplatelet txoj kev kho yog ib tug yeeb tshuaj, "Plavix". Niaj hnub no kuj yog heev feem ntau siv rau hauv cov tshuaj, xws li ib tug analogue ntawm Plavix zilt. Cov tshuaj muaj pes tsawg leeg nrog rau ob clopidogrel thiab acetylsalicylic acid. Lub ntsiab kev txiav txim ntawm tus kws npaj raws kev coj kom lub inhibition ntawm ADP-receptor lub luag hauj lwm rau lub aggregation ntawm cov ntshav (nyob rau hauv particular platelets). Ib tug txawv feature ntawm kev npaj yog irreversible losis tswvyim dabtsi ntawm ADP-receptors, uas ua rau yus mus rau ib tug ruaj khov ntxim rau aggregation. Raws li ib tug tshwm sim ntawm receptor kev ua si yog rov qab los tsuas yog nyob rau txoj kev tuag ntawm cov laus thiab cov synthesis ntawm tshiab platelets. Xws li yog cov qauv thiab cov mechanism ntawm qhov kev txiav txim ntawm lub analogue ntawm Plavix - zilta.

Clopidogrel (Plavix analogue) yog siv nyob rau hauv ib tug ntau npaum ntawm 75 milligrams. Nyob rau hauv thawj hnub ntawm kev noj cov tshuaj pom ib tug tseem ceeb attenuation ntawm platelet aggregation kev ua si. Thaum tom ntej daim ntawv thov ntawm ib tug yeeb tshuaj nyhuv qab. Teev voj voog kws yog kev npaj qhov nruab nrab ntawm peb mus rau xya hnub. Tom qab discontinuation ntawm cov tshuaj nyhuv nws yog cai (tsis siab tshiab kom txog thaum feem ntau ntawm cov platelet muaj pes tsawg leeg) rau lwm lub sij hawm ntawm tsib mus rau xya hnub.

Salicylic acid ua inhibition ntawm platelet aggregation vim irreversible inhibition ntawm cyclooxygenase (COX-1). Raws li ib tug tsim nyog tau, txo thromboxane synthesis thiab attenuated vasoconstriction. Raws li nyob rau hauv cov ntaub ntawv ntawm clopidogrel ntxias cov nyhuv yog khaws cia tshaj lub neej ntawm cov ntshav (platelets).

Vim li cas siv ib tug analogue ntawm Plavix thiab cov tshuaj nws tus kheej? Cov feem ntau siv ua ke nrog antiplatelet txoj kev kho yog tsis txhaum yuav muaj vascular thrombosis ntawm tej qhov chaw nyob rau hauv lub xub ntiag ntawm atherosclerotic txhab.

Muaj yog ib tug ntau nrov analogue ntawm Plavix - listab. Txawm li cas los, nws, zoo li ntau lwm tus neeg (klopilet, lopirel, plargil, detromb, plogrel, Trocken, kardutol), yog tsis muaj dav siv nyob rau hauv niaj hnub mob xyaum.

Plavix los yog zilt?

Feem ntau cov kws kho mob leaning ntawm kev siv ntawm Plavix, txij li thaum nws cov hauj lwm zoo tau muaj pov thawj los ntawm randomized tej kev txom nyem. Pov thawj puag cov tshuaj tau txais rov qab rau hauv 2007 thiab tshaj yav dhau los tsib lub xyoos, lub active siv xwb ntxiv dag zog rau lub npe ntawm cov "zoo tshaj plaws cov khoom". Raws li rau zilta, nws ua hauj lwm zoo, raws li sau tseg los ntawm cov kws kho mob lawv tus kheej, me ntsis qis dua lub tshaj tawm hais tias, yog li piv rau nws cov counterpart nyob rau hauv kev sib hwm ntawm qhov zoo tshaj ntawm kev kho mob kev kho mob nws tsis tau. Feem ntau, zaum ntseeg tias cov uas tsis muaj hauj lwm zoo ntawm lub yav tas yog vim lub txhaum ntawm lub hauj txheej txheem ntawm manufacturing cov tshuaj. Biophysics tib nco ntsoov ib co tsis sib xws nyob rau hauv molecular qauv ntawm Plavix thiab nws analogue.

Raws li rau tus nqi, nws ho poob Plavix ziltu. Yog li, tus nqi ntawm lub thawj peb lub sij hawm tus nqi ntawm lub thib ob. Nyob rau hauv feem ntau, tus nqi ntawm cov tshuaj ua rau qhov yuav tsum tau siv inefficient counterparts. Nyob rau hauv tseeb ntawm cov kws kho mob uas niaj hnub kho mob, yog tias koj yuav tsis tau lub kim Plavix yuav tsum tsis txhob yuav ib tug pheej yig dua analogue thereof - zilt. Kiag li tso tseg lub nkag ntawm cov tshuaj yog tsis pom zoo.

Raws li xws li ib tug yeeb tshuaj raws li "Ko Plavix," ces nws yog ib txwm ib tug nce ntau npaum ntawm ib tug ib feem ntawm lub Cheebtsam (100 thiab 75 mg ntawm salicylic acid, thiab clopidogrel, ntsig txog).

Tu siab, rau hnub tim raug technology "Plavix" medicament, raws li zoo raws li nws cov constituent Cheebtsam yog kim heev, uas ua rau yus siab nqi ntawm cov tshuaj. Cov kev pab rau cov kev pab ntawm affluent cov neeg mob tuaj zoo heev analogues ntawm brand-lub npe tshuaj.