"Ursofalk": analogues, cov lus qhia siv thiab tso tawm ntaub ntawv

Cov tshuaj "Ursofalk" cov lus qhia siv rau kev siv cov tshuaj siv nrog ntau cov kev ua, uas muaj, nrog rau lwm cov, hepatoprotective, cholelitholytic, immunomodulating properties. Tsis tas li, cov tshuaj no thiaj li txo cov qib roj cholesterol hauv cov ntshav.

Yam khoom tseem ceeb

Tus kab mob sib kis ntawm cov tshuaj yog ursodeoxycholic acid. Nws yog nyob rau hauv ib qho nyiaj nyob rau hauv ib tug tib neeg ntawm tus kheej, tab sis raws li ib tug ntawm cov kev ua txhaum ntawm kev ua hauj lwm ntawm daim siab, lub synthesis thiab, raws li, cov ntsiab lus ntawm cov tshuaj nyob rau hauv lub bile yuav txo.

Ursodeoxycholic acid raws li ib tug lub ntsiab muaj yog tam sim no tsis tsuas nyob rau hauv cov kev npaj "Ursofalk". Analogs nyob rau hauv cov composition thiab pharmacological cov cuab yeej yog cov tshuaj xws li Ursosan, Ursoliv, Urdoksa. Cia tham txog lawv hauv qab no.

Therapeutic teebmeem ntawm "Ursofalk"

• Cov choleretic nyhuv yog tshwm sim hauv qhov txo ntawm cov dej hydrophobic acids thiab nce hauv lawv cov kua tso rau hauv lub lumen ntawm txoj hnyuv. Tsis tas li ntawd, cov tshuaj, vim nws txoj kev txuas nrog cov receptors hauv nrogum, txo qhov nqus ntawm cov tshuaj lom hydrophobic acids.
• Cov nyhuv ntawm immunomodulatory yog vim qhov tseeb tias qhov ursodeoxycholic acid tuaj yeem txo qhov qhia txog HLA lwg me me ntawm cov tshuaj ua ntej ntawm hepatocytes, thiab qib ob HLA lwg me me ntawm cholangiocytes. Tsis tas li ntawd, cov tshuaj kho tau cov synthesis ntawm pro-inflammatory cytokines.
• Lub cytoprotective nyhuv yog lub peev xwm ntawm cov khoom ua rau kom nkag mus rau hauv lipid txheej ntawm lub cell membrane, raws li ib qho ntawm cov cell membrane stabilizes, nws cov khoom tiv thaiv zoo tuaj.
• Hypercholesterolemic cov nyhuv yog raws li nyob rau hauv lub yuav txo tau nyob rau hauv lub ileum haum thiab txo cov roj uas txhaws synthesis nyob rau hauv lub siab, zoo li raws li nws cov feem nyob rau hauv lub bile.

Dhau li ntawm tus saum toj no los, cov tshuaj "Ursofalk" (cov lus qhia rau kev siv rawsli) Cov ntaub ntawv kua siv lead ua nrog ib tug roj uas txhaws taus molecule uas txo lithogenicity bile. Vim lub transformation ntawm cholesterol sib txuas, tsim ntawm pob zeb txo thiab lawv dissolution tshwm sim.

Pharmacokinetics

Tom qab txoj kev siv tshuaj hauv cov tshuaj hauv cov hnyuv, kev nqus ntawm ursodeoxycholic acid tshwm sim, nrog kev nqus los ntawm kev thauj cov kab mob nyob rau hauv nrog nrog qhov chaw hauv lub davhlau ya nyob twg, thiab los ntawm kev ywj pheej nyob hauv jejunum thiab hauv plab. Kwv yees li ntawm 60-80 feem pua ntawm cov koob tshuaj uas tau txais raug rau tag nrho cov ntshav khiav.

Cov khoom nquag yog metabolized nyob rau hauv daim siab thiab ib nrab disintegrates nyob rau hauv cov hnyuv, uas ua rau muaj kev lom ntawm xya-keto-lithocholic acid, uas nyob rau hauv tig yog absorbed mus rau tag nrho cov ntshav txaus rau ib qho tseem ceeb thiab detoxified nyob rau hauv daim siab. Ib nrab ntawm lub neej ntawm cov tshuaj yog peb mus rau tsib hnub. Yeej, nws yog tawm nrog cov quav hauv daim ntawv ntawm cov metabolites.

Cov kev qhia rau kev siv

Cov tshuaj "Ursofalk" cov lus qhia rau kev siv qhia tau hais tias kev siv rau cov kab mob ntawm lub gallbladder, daim siab, nrog kev nce hauv cov roj ntshav cholesterol, cholestasis, txo qis qee lub siab ua haujlwm. Cov mob xws li kev mob nkeeg, kev paub txog kabmob ntawm lub siab (thawj), daim npav pobtxha (reflux), gastritis, sclerosing cholangitis (thawj), biliary reflux-esophagitis, kabmob siab ntawm txawv etiology, cystic fibrosis tuaj yeem sau tseg.

Cov tshuaj no tau sau rau hauv cov pob zeb hauv lub gallbladder, tab sis tsuas yog tias lawv xoo hluav taws xob tsis zoo, nyob ntawm kab uas lawv tsis loj tshaj kaum tsib millimeters, thiab tus neeg mob tsis tuaj yeem cuam tshuam kev ua haujlwm ntawm lub gallbladder. Lub medicament kuj yog siv nyob rau hauv cov ntaub ntawv ntawm daim siab toxicity (e.g., haus dej cawv lom), nws pathology nrog cholestasis (nyob rau hauv cov me nyuam), biliary dyskinesia, atresia ntawm intrahepatic kua tsib ducts. Nws nqa mus cov neeg mob nyob rau hauv parenteral kev noj haus, nyob rau hauv thiaj li yuav tshem tawm stagnation ntawm cov kua tsib, raws li zoo raws li cov neeg uas tau muaj kev phais rau ib tug lub siab hloov.

Ua ib tus neeg sawv cev tiv thaiv tau muab tshuaj rau "Ursofalk" (analogues ntawm cov tshuaj kuj tuaj yeem siv tau rau cov no), thaum noj cov tshuaj uas tuaj yeem cuam tshuam rau kev ua haujlwm ntawm lub siab (hormonal contraceptives, tshuaj nrog cov cholestatic effect).

Daim ntawv ntawm qhov teeb meem thiab muaj pes tsawg leeg

Ob hom kev tso tawm muaj cov tshuaj "Ursofalk": tshem tawm (analogues tsis tuaj kawm ntawv, ua nyob hauv Switzerland) thiab tshuaj ntsiav (analogues muaj, manufactured nyob hauv lub teb chaws Yelemees). Tus thawj version ntawm yeeb tshuaj yog siv rau cov menyuam yaus lossis cov neeg uas nqos nyuaj. Cov hlab ntim yog cov gelatinous, opaque, khoom, lub hau thiab lub cev muaj xim dawb, sab hauv - dawb granules los yog hmoov. Ua rau cov pob khoom ntawm 10, 25, 50 los sis 100 daim. Qhov kev ncua kuj tseem muaj xim dawb, nws yog ib qho zoo sib xws, muaj cua npuas, thiab muaj ib lub txiv qaub. Ua rau 250 ml vials, ib rab diav muaj qhov tso.

250 milligrams of ursodeoxycholic acid yog muaj nyob rau hauv ib qho tshuaj ntsiav ntawm cov tshuaj, tib yam li cov khoom nquag muaj nyob rau hauv tsib milliliters (ib qho ntsuas diav) ntawm kev rho tawm hauv Ursofalk. Lub syrup muaj koom haum pab Cheebtsam: glycerol, anhydrous citric acid, xylitol, propylene glycol, sodium tshuaj dawb, microcrystalline cellulose, benzoic acid, txiv qaub tsw, sodium citrate, purified dej, sodium cyclamate. Cov khoom xyaw theem nrab hauv cov hlab ntoos yog colloidal silicon dioxide, titanium dioxide, sodium lauryl sulfate, hmoov txhuv nplej siab pob kws, magnesium stearate, gelatin, purified water.

Yuav ua li cas noj Ursofalk

Cov tshuaj noj thaum muaj kev sib tham ntawm ib zaug xwb yog ntshaw kom noj thaum yav tsaus ntuj. Cov phais plab yog nqos tsis zom, thiab ntxhua nrog dej kom zoo. Raws li tau hais tseg, cov tshuaj "Ursofalk" rau cov menyuam yaus yog zoo dua los siv raws li kev ncua (phom). Qhov hnyav yuav tsum tau ua los ntawm tus kws kho mob, raws li qhov xwm txheej ntawm tus kab mob thiab tus yam ntxwv ntawm tus neeg mob lub cev. Cov me nyuam mos liab (ntawm qhov hnyav ntawm tsib kilograms) ua ntej yuav txaj yuav tsum tau muab peb lub hlis twg ntawm lub hnub ntsuas phom.

Feem ntau, nrog rau kab mob siab, niaj hnub noj tshuaj rau cov neeg laus yog 10-15 mg ntawm ib kilogram phaus, cov kev kho mob kav li ntawm 6 lub hlis mus rau ob xyoos, thaum noj cov tshuaj so tsis siv. Rau cov neeg uas paub biliary reflux esophagitis los yog biliary reflux gastritis, qhov tshuaj txhua hnub ntawm qhov tshuaj Ursofalk yog 250 mg, kev kho mob yog kaum rau kaum-plaub hnub. Nrog sclerosing cholangitis thiab biliary cirrhosis, ib koob ntawm 10-15 mg ntawm ib kilogram ntawm qhov hnyav feem ntau yog tauj ib hnub, tab sis yog tias tsim nyog, cov koob tshuaj tau nce mus rau 20 mg rau 1 kg. Txoj kev kho feem ntau yuav kav li ntawm 6 hlis mus rau ob xyoos. Cov neeg mob nrog cystic fibrosis noj cov tshuaj txhua hnub ntawm ib koob ntawm 20-30 mg ib kilogram ntawm qhov hnyav tshaj li ntawm 6 lub hlis mus rau ob xyoos. Nyob rau hauv cov ntaub ntawv ntawm kev lom nqaij siab, nws yog qhia hais tias cov tshuaj yuav tsum tau noj nyob rau ntawm ib hnub twg ntawm 10-15 mg ntawm ib kilogram ntawm qhov ceeb thawj rau 6 mus rau kaum ob lub hlis.

Cov tshuaj "Ursofalk." Analogues

Cia ua ib qho kev qhia sib piv ntawm cov tshuaj nrog cov yeeb tshuaj uas zoo sib xws nyob rau hauv cov khoom xyaw thiab cov khoom lag luam.

• Cov tshuaj "Ursosan". Cov khoom no yog tsim nyob rau hauv Czech koom pheej thiab lub teb chaws Yelemees, nws muaj tsuas yog nyob rau hauv daim ntawv ntawm tsiav tshuaj. Lub mechanism ntawm kev txiav txim ntawm cov tshuaj yog zoo sib xws. Txawm li cas los xij, cov kws kho mob, cov kws kho mob siab, cov kws kho mob muaj kab mob hauv cov lus nug txog kev siv yeeb tshuaj zoo dua: "Ursosan" los yog "Ursofalk", tsis muaj lus teb tias nws yog qhov zoo tshaj los xaiv thib ob. Cov kev txiav txim siab no yog tsim los ntawm cov kws kho mob tshwj xeeb vim lawv qhov kev soj ntsuam thiab tus neeg mob xyuas. Cov tshuaj "Ursofalk" muab hloov yooj yim dua qhov analogue nug, nws kuj ceev nrooj normalizes lub xeev lub cev ua haujlwm. Tab sis tsis txhob hnov qab txog tus yam ntxwv ntawm lub cev, muaj cov neeg uas pab "Ursosan" pab zoo dua. Tsis tas li ntawd, qhov tshuaj no yog pheej yig dua: ntim nrog 50 tshuaj tiv thaiv yuav raug nqi 650-830 plhom, hos rau 50 tshuaj tiv thaiv "Ursofalk" yuav tau them 850-1200 rubles.
• Lub ntsiab lus ntawm "Urdoksa." Cov tshuaj noj yog tshuaj yeeb tshuaj. Txawm li cas los, lub tuam txhab kev lag luam uas tsim tawm nws yuav cov khoom xyaw tsim nyog nyob txawv teb chaws, thiab nyob rau hauv Russia tsuas yog tus txheej txheem ntawm kev tsim cov tshuaj yeeb tshwm sim. Nws kuj muaj nyob rau hauv capsules, tus nqi rau 50 pieces nws txawv ntawm 440-960 RUB. Ob cov tshuaj muaj ntsis zoo ib yam hauv cov khoom siv tshuaj, tsis muaj qhov sib txawv hauv cov nyhuv.
• Cov tshuaj "Ursoliv." Cov tshuaj, raws li nyob rau hauv cov ntaub ntawv dhau los, yog tsim nyob rau hauv Russia. Tib lub sij hawm, coob tus neeg tau nco tias tsis tag nrho cov npe tshuaj, qhov no yog qhov zoo tshaj plaws uas dissolves pob zeb hauv lub zais zis. Tab sis kuj muaj cov neeg uas tau txais kev kho mob zoo dua nrog cov tshuaj "Ursofalk". Capsules muaj cov kab zoo sib xws, yog li nws yog qhov nyuaj muab qhov preference rau qhov no los yog tias variant. Yog hais tias koj tsom rau ntawm tus nqi, nws yog zoo dua mus yuav cov tshuaj "Ursoliv", nws nqi tsawg dua - 460-905 rau 50 tshuaj.

Cov txheej txheem phiv

Nws yog qhov zoo heev rau kev hloov cov tshuaj "Ursofalk" rau cov neeg mob. Analogs ntawm cov tshuaj kuj yog characterized zoo tolerability. Qee zaum, tiv thaiv cov keeb kwm kho mob, calcification ntawm gallstones tshwm sim, cov quav tawv nqaij tsim tawm, cov hauj sim tshwm sim hauv cov epigastrium. Tsis tas li ntawd, kev ua xua yuav tsim nyob rau hauv daim ntawv ntawm daim tawv nqaij khaus, khaus. Tsis tau qhia txog kev siv tshuaj ntau overdose tau qhia txog hnub tim.

Contraindications

Cov neeg mob siab rau lub luag hauj lwm ntawm cov tshuaj yeeb dej caw yog ib lub hauv paus rau kev tsis kam siv. Contraindicated tshuaj rau cov neeg uas muaj mob cholangitis, obturation ntawm cystic los yog cov kab mob hauv cov kab mob, mob cholessstitis. Tsis txhob muab cov tshuaj rau cov neeg mob kev txom nyem los ntawm lub cev tsis muaj zog ntawm lub npav, tus ciam teb.

Daim ntawv thov nyob rau hauv cev xeeb tub thiab lactation

Raws li kev tshawb fawb, ursodeoxycholic acid tsis qhia tias mutagenic, teratogenic, embryotoxic kev ua, tab sis nws muaj peev xwm mus rau hauv cov teeb meem hematoplacental thiab feem xyuam rau txoj kev xeeb ntawm kev xeeb tub tsis tau kawm tag nrho. Yog li, yuav tsum tau siv cov tshuaj "Ursofalk" thaum lub caij tus me nyuam tuaj yeem ua tau yog tias tsim nyog thiab raws li tus kws kho mob cov tshuaj. Kev siv cov tshuaj nyob hauv lub sijhawm ua lactation yog tsis tuaj.

Kev sib tham nrog lwm cov tshuaj

Simultaneous txais tos ntawm cov tshuaj nrog antacid cov neeg ua haujlwm uas muaj txhuas hydroxide, thiab nrog cov tshuaj "Kolestipol" thiab "Kolestyramine" ua rau txo qis rau lub cev nqus dej ntawm cov khoom nquag. Cov tshuaj yuav hloov cov concentration hauv ntshav ntshav ntawm yeeb tshuaj "Ciclosporin." Yog tias xav tau kev sib koom tes ntawm kev siv tshuaj xws li, lawv yuav tsum tau noj thaum sib luag ntawm tsawg kawg yog ob xuab moos.