Tsis tshua muaj molecular yuag heparins tshuaj, indications rau kev siv

Therapy ntawm thrombosis thiab thromboembolic txheej xwm tsis yog tsis muaj anticoagulants, uas muaj xws li tsis tshua muaj molecular yuag heparins. Cov tshuaj nyob rau hauv nyob tus yeees ntawm cov tshuaj hloov ntshav, li no es ua patency.

Hom ntawm ncaj qha anticoagulants

Xav lub mechanism ntawm cov nyhuv ntawm antithrombotic tebchaw tej zaum yuav tau muab sau tseg hais tias lawv yog tib neeg thiab indirect kev txiav txim. Cov feem ntau siv ua ntej pab pawg neeg ntawm tshuaj.

Anticoagulants direct cawv rau cov qauv raug muab faib ua tsawg molecular yuag heparins thiab unfractionated. Lawv muaj peev xwm kuj yuav ncaj qha thrombin inhibitor, nws yog yuav ua li cas, piv txwv li, hirudin.

Tsis tshua muaj molecular yuag heparins Feature

Lawv txawv hu ua fractionated tebchaw uas nws nruab nrab molecular yuag yog hom twg los ntawm 4000 mus 6000 daltons. Lawv kev ua ub no uas muaj feem rau ib qho indirect inhibition ntawm cov tsim thiab kev ua si ntawm lub enzyme thrombin. Xws li ib tug nyhuv heparin niamntiav rau cov ntshav coagulation tau Xa. Cov no muaj anticoagulant thiab antithrombotic nyhuv.

Tsis tshua muaj molecular yuag heparins yog tau los ntawm unfractionated tshuaj cais los ntawm npua plab hnyuv epithelium, thaum lub sij hawm tus txheej txheem ntawm cov tshuaj los yog enzymatic depolymerization. Raws li ib tug tshwm sim ntawm cov tshuaj tiv thaiv no polysaccharide saw yog shortened los ntawm ib feem peb ntawm nws cov thawj ntev, uas yuav pab kom tsis txhob muaj lub anticoagulant molecule.

Muaj ntau ntau yam uas tsis muaj molecular yuag heparins, thiab qhov no faib yog raws li nyob rau txoj kev ntawm tau ntsev-muaj tebchaw.

muab

Lawv formulations yog tshuaj daws teeb meem rau subcutaneous los yog tso dej raws leeg thawj coj. Lawv feem ntau yog tau ntim rau hauv ampules los yog pov tseg koob txhaj tshuaj.

Tsis tshua muaj molecular yuag heparins tsis ua nyob rau hauv cov ntsiav tshuaj.

Intramuscularly tshuaj yog tsis siv.

Hauj lwm "Gemapaksan" tshuaj

Nws yog hais txog cov tshuaj nrog lawv anticoagulant los. Lub active ingredient yog nyob rau hauv daim ntawv ntawm cov enoxaparin sodium ntsev, uas yog ib tug derivative ntawm heparin. Qhov no hloov kho muab ib tug high adsorption thaum muab subcutaneously thiab ib tug neeg uas tsis muaj rhiab heev.

Nws yog ua los ntawm cov Italian lub tuam txhab "Italfarmako Spa" raws li ib tug ntshiab, tsis muaj kob los yog lub teeb-daj tshuaj cov kev txhaj tshuaj fej nyob rau hauv koob txhaj tshuaj ntawm 0.2, 0.4 los yog 0.6 ml.

enoxaparin sodium tshuaj yog mus rau 2000 IU mus rau 20 mg; 4000 IU rau 40 mg thiab 6000 mg ntawm 60 IU. Lub active ingredient yog yaj nyob rau hauv dej cov tshuaj txhaj.
Enoxaparin sodium manifests nyob rau hauv ib tug ntau npaum ntawm 100 IU ib 1 mg ntawm siab inhibitory ntxim rau cov ntshav coagulation tau Xa thiab tsawg feem antithrombin ntawm ib koob tshuaj 28 IU ib 1 mg.

Kev siv cov tshuaj yeeb tshuaj ntau nyob rau hauv ntau yam kab mob tsis ua rau ib qho kev nce nyob rau hauv lub caij ntawm ntshav poob.

Prophylactic sodium enoksaparinovaya ntau npaum ntawd tsis hloov lub tshuab txais ib nrab thromboplastin lub sij hawm, tsis ua txhaum ib tug platelet clumping thiab lawv kev twb kev txuas cov txheej txheem rau cov fibrinogen molecules.

Tsis tshua muaj molecular yuag heparins nyob rau hauv ib tug ntau dua cov tshuaj concentration (6000 IU nyob rau hauv 0.6 ml) yog siv:

• rau txoj kev kho ntawm thrombosis nyob rau hauv cov leeg ntawm lub sib sib zog nqus;
• tsim tsis ruaj tsis khov angina thiab myocardial stunning infarcted nqaij mob nyob rau hauv ua ke nrog nrog acetylsalicylic acid;
• rau kev tiv thaiv ntawm coagulation nce rau lub duration ntawm lub hemodialysis txoj kev.

Introduction tshuaj subcutaneous koob tshuaj ntawm 2000 IU thiab 4000 ntawm 0.2 thiab 0.4 ml, ntsig txog, yog siv los mus tiv thaiv thrombosis thiab venous thromboembolic mob system:

• thaum lub sij hawm orthopedic phais haujlwm cim;
• txaj rau cov neeg mob uas mob ua pa insufficiency los yog mob system unit 3 thiab hom 4;
• mob kis los yog rheumatic kab mob, qhov chaw uas muaj ib tug uas yuav tau rau cov ntshav txhaws;
• cov neeg laus cov neeg mob;
• nrog tshaj roj deposition;
• thaum lawm txoj kev kho.

Lub tshuaj no yog siv subcutaneously mus rau hauv lub plab phab ntsa, nyob rau hauv nws cov posterior thiab anterolateral tsam.

Tshuaj yog contraindicated rau cov thrombocytopenia, los ntshav, txhaws mob, ulcerative kab mob ntawm lub qog ua kua membrane ntawm lub plab thiab duodenum, subacute kab mob endocarditis, mob ntshav qab zib, ntshav qab zib, rhiab heev thiab cev xeeb tub.

"Gemapaksan" tshuaj: nqi

Tus nqi ntawm cov kev txhaj tshuaj muaj 2000 IU koob txhaj nyob rau hauv 0.2 mL ntawm rau daim ntawm 955 rubles.

Yog xav paub ntxiv ntau npaum tshuaj "Gemapaksan 'nqi yog hom twg los ntawm 1,500 rubles ib pob nrog rau koob txhaj tshuaj.

Hauj lwm "Clexane" tshuaj

Nws yog hais txog tib yam txhais tau tias nyob rau hauv lub hauv paus ntawm enoxaparin sodium. Ua los ntawm qhov Fabkis lub tuam txhab "Sanofi Aventis" raws li ib tug tshuaj ntshiab kua uas yuav ua tau tsis muaj kob los yog nrog me ntsis daj zas.

Muaj ntau npaum "Clexane" kev npaj ntawm 10000, 8000, 6000, 4000 thiab 2000 IU ntawm enoxaparin sodium rau 1.0; 0.8; 0.6; 0.4; 0.2 ml ntawm cov kua tshuaj, ntsig txog. Lub active muaj nyob rau hauv cov tshuaj no 1 mg 1,000 IU.

Tsis tshua muaj molecular yuag heparins yog manufactured nyob rau hauv lub khob koob txhaj tshuaj, uas tej zaum yuav nyob rau hauv ib lub pob 2 los yog 10 daim.

Tshuaj "Clexane" rau kab mob HIV kev tiv thaiv thrombotic thiab thromboembolic mob nyob rau hauv cov leeg thaum lub sij hawm ib tug phais pab muaj feem xyuam rau orthopedics, thiab hemodialysis.

Cov tshuaj twb muab subcutaneously ntawm tshem tawm ntawm venous thrombotic lub xeev nyob rau hauv lub sib sib zog nqus ntsws thiab mus rau hauv lub artery.

Tshuaj kho angina tsis ruaj tsis khov xwm ntawm myocardial stunning thiab myocardial nqaij nyob rau hauv nrog cov ntsiav tshuaj "aspirin".

"Clexane" tshuaj: nqi

Tus nqi ntawm cov kev txhaj tshuaj muaj 2000 IU 0.2 mL ib koob txhaj yog 175 rubles.

Ib unit koob tshuaj 4,000 IU nrog 0.4 ml ntawm tshiav 280 yuav tau them rau 6,000 IU ib 0.6 ml - 440 rubles 8000 IU ib 0.8 ml - 495 rubles.

Nyob rau hauv kev npaj "Clexane" nqi ib chav tsev ntawm 10 daim nrog ib koob tshuaj 20 mg, 40 mg thiab 80 mg yog 1685, 2750, 4000 rubles.

Hauj lwm "Fragmin" tshuaj

Lub active feem ntawm cov tshuaj yog ib tug derivative ntawm heparin tshuaj sawv cev dalteparin sodium. Nws yog tau los ntawm depolymerization los ntawm qhov kev txiav txim ntawm cov pa roj nitrous acid , ua raws li los ntawm purification siv ion pauv chromatography. Dalteparinovaya sodium ntsev comprises polysaccharide chains raug sulphation, nrog ib tug nruab nrab molecular ceeb thawj los ntawm tsib txhiab daltons.

Koom Haum protrude dej txhaj tshuaj thiab sodium chloride ntsev. Belgian medicament "Fragmin" phau ntawv qhia txog raws li ib tug tshuaj rau kev txhaj tshuaj subcutaneous thiab tso dej thawj coj nyob rau hauv cov kua daim ntawv tshab tsis muaj kob los yog yellowish tint.

Nws tso tawm nyob rau hauv monodose iav koob txhaj tshuaj ntawm 2500 IU ib 0.2 ml; 5000 IU ib 0.2 ml; 7500 IU ib 0.3 ml; 10,000 IU nyob rau hauv 1.0 ml; 12,500 IU nyob rau hauv 0.5 ml; 15,000 IU ib 0.6 ml; 18,000 IU ib 0,72 ml.

Tshuaj "Fragmin" phau ntawv xav siv ib tug tiv thaiv kev ntsuas rau tus tswj ntawm cov ntshav txhaws mechanism nyob rau hauv hemodialysis thiab haemofiltration kev ua ub no aimed ntawm cov kev kho mob ntawm lub raum tsis ua hauj lwm, kom tsis txhob tsim ntawm txhaws nyob rau hauv phais.

Lub medicament yog siv rau cov tshem tawm cov thromboembolic txhab bedridden cov neeg mob.

Tshuaj kho angina, tsis ruaj tsis khov thiab infarct myocardial stunning lub xeev ntawm cov nqaij, symptomatic venous thromboembolism.

Hauj lwm ntawm cov tshuaj "Anfibra"

Nws tsis tshua muaj molecular yuag heparins raug xa mus rau Lavxias teb sab lub tuam txhab OJSC "Veropharm". Muaj yog ib tug ntshiab tov cov kev txhaj tshuaj, uas tej zaum yuav tsis muaj kob los yog yellowish tint.

Lwm txhais tau tias yog enoxaparin sodium ntsev, uas tej zaum yuav muaj 2000 IU nyob rau hauv 0.2 ml; 4000 IU ib 0.4 ml; 6000 IU ib 0.6 ml; 8000 IU ib 0.8 ml; 10,000 IU nyob rau hauv 1.0 ml. Lub distilled dej yog siv raws li kuab.

Nws prepacked nyob rau hauv ampules los yog koob txhaj tshuaj ntawm 1ml, uas yog 2, 5, thiab 10 pieces uas tau ntim rau hauv packs ntawm cardboard.

Tshuaj "Anfibra" kev qhia yog pom zoo rau cov kev tiv thaiv ntawm thromboembolic mob thaum kev khiav hauj lwm manipulation thiab hemodialysis nyob rau hauv cov kev kho mob ntawm los khov rau ntawd tsim nyob rau hauv lub tob-dag hlab ntsha.

Tshuaj kho cov tsis ruaj tsis khov xwm ntawm angina thiab mob cov nqaij leeg infarct lub xeev nyob rau hauv uas tsis muaj hniav Q nyob rau electrocardiogram.

Hauj lwm ntawm "Fraksiparin"

Los ntawm tsawg molecular yuag heparins yuav nadroparin calcium, uas yog tau thaum lub sij hawm depolymerization txheej txheem. Nws molecules yog glycosaminoglycans, qhov nruab nrab molecular ceeb thawj los ntawm uas yog sib npaug zos rau 4.300 Daltons.

Kev npaj "Fraksiparin" (subcutaneous tshuaj) nyob rau hauv nws muaj pes tsawg leeg muaj calcium hydroxide thiab ntsev nadroparin, uas yog yaj nyob rau hauv injectable dej.

Ntau npaum ntawm active ingredient yog 2850 KUV nyob rau hauv 0.3 ml; 3800 KUV 0.4 ml; 5700 KUV 0.6 ml, 0.8 KUV 7600 ml, 9500 KUV nyob rau hauv 1 ml.

Cov kev npaj yog ib tug tshab los yog me ntsis opalescent kua, uas muaj ib lub teeb daj xim los yog kiag li tsis muaj kob.

Nadroparinovaya ntsev zoo protein uake rau antithrombin III, uas ua rau ceev inhibition ntawm qhov zoo tshaj Xa. Cov tshuaj yeeb dej caw activates inhibitor muab transformation ntawm cov ntaub so ntswg tau, lowers ntshav viscosity thiab muaj zog platelet membrane permeability thiab granulocytic hlwb. Yog li ntawd nws nqa antithrombotic nyhuv ntawm cov tshuaj.

Tshuaj "Fraksiparin" tshuaj los mus tiv thaiv thromboembolic mob thaum kev khiav hauj lwm orthopedic manipulation ntawm cov ua cim thiab hemodialysis. Lub tshuaj no yog muab rau cov neeg mob muaj ib tug yuav muaj cov ntshav los khov rau ntawd tag, mob ua pa insufficiency thiab kab mob plawv, tsis ruaj tsis khov angina pectoris, myocardial stunning myocardial nqaij mus tsis muaj Q-yoj.

Kev siv cov anticoagulants nyob rau hauv tus me nyuam-tau cov kabmob

Tsis tshua muaj molecular yuag heparins nyob rau hauv cev xeeb tub yog muab rau cov neeg mob uas muaj ntshav mob tsis tsim lub placental ntshav txhaws uas ua rau rho me nyuam tawm, rau preeklampsicheskomu ntawm ntshav siab, dhas tus me nyuam cov rooj zaum nrog hnyav los ntshav, qeeb txoj kev loj hlob ntawm lub embryo nyob rau hauv lub tsev me nyuam, yuav ua tau rau cov uas tsis muaj tus me nyuam luj.

Tej anticoagulants cov kws kho rau cov poj niam nyob rau hauv txoj hauj lwm nrog rau cov tau muaj kev pheej hmoo ntawm los khov rau ntawd tsim nyob rau hauv lub sib sib zog nqus leeg, piv txwv li cov qis extremities, raws li zoo raws li lub ntsws leeg occlusion.

LMWH txoj kev kho yog ib tug mob cov txheej txheem, nyob rau hauv uas ib tug cev xeeb tub tus neeg mob nkag mus rau txhua txhua hnub tshuaj nyob rau hauv daim tawv nqaij nyob rau hauv lub plab mog.

Txawm li cas los, thaum lub sij hawm soj ntsuam randomized twb tau xeem tau uas ua pov thawj hais tias cov kev siv ntawm tej anticoagulants yog feem ntau tsis conducive mus zoo ntxim. Tsis tas li ntawd pom tias tsis muaj molecular yuag heparins txoj kev kho yuav ua mob rau tus niam lub cev txuam nrog nce los ntshav thiab tsis mob nyem nyob rau hauv txoj hauj lwm.

Cov kev tshawb fawb tau qhia tias cov abolition ntawm anticoagulant kev kho mob muaj peev xwm cawm tau ntau tus pojniam ruaj mob cov tsos mob thaum nqa tus me nyuam.

Cov lus qhia rau kev siv cov npaj raws li uas tsis muaj molecular yuag heparin txoj kev kho yog ua rau cev xeeb tub.