Tshuaj "allopurinol": xyuas ntawm cov kws kho mob, indications, phiv

Rau hnub tim, tshuaj "allopurinol" yog yooj yim (thawj thiab pathogenetically grounded) ib tug yeeb tshuaj uas yog siv nyob rau hauv cov kev kho mob ntawm cov kab mob xws li gout. Txhua tus neeg ua ntej koj sim ib yam dab tsi tshiab, sim mus nrhiav cov tseem ceeb cov lus qhia txog nws. Yog li ntawd peb muaj kam nyob rau hauv ntau yam nrog thaum tib yuav tsum tau thov "Allopurinol". Xyuas ntawm cov neeg mob thiab cov kws kho mob yuav tsum tau nthuav tawm nyob rau hauv peb tsab xov xwm thiab koj yuav paub tias dab tsi yuav ntshai thaum noj cov tshuaj no.

Pharmacological yam ntxwv ntawm cov tshuaj

"Allopurinol" yog hais txog cov pab pawg neeg protivopodagricakih npaj. Lub ntsiab active tshuaj - allopurinol thiab nws cov active metabolite oksipurinola. Cov pharmacodynamic los vim tau ua txhaum ntawm lub synthesis ntawm uric acid nrog txoj kev loj hlob urostaticheskogo nyhuv. Qhov no nws thiaj li ua rau yus mus rau ib tug txo ntawm nws cov concentration, ua raws li los ntawm dissolving urate.

Vim mus rau qhov zoo solubility "allopurinol" muaj siab bioavailability. Cov tshuaj no yog zoo yaim los ntawm lub lumen ntawm cov hnyuv. Nyob rau hauv lub plab mus rau hauv lub mauj kev tsis poob. nyob rau hauv lub xub ntiag ntawm cov ntshav ntshav tau tau cai rau ib nrab ib teev tom qab cov thawj coj, thiab lub siab tshaj plaws concentration cai tom qab 1.5 teev. Raws li, qhov nyiaj pab ntau tshaj concentration ntawm ib tug metabolite ntawm allopurinol - oksipurinola cai peb teev tom qab qhov ncauj thawj coj.

Cov tshuaj muaj ib tug ntev ib nrab-lub neej thiab vim nws muaj peev xwm sawv ntawm cumulation. Cov neeg mob thaum pib ntawm txoj kev kho, yog ib qho muaj zog concentration ntawm cov tshuaj uas stabilizes tom qab ib mus rau ob lub lim piam ntawm txoj kev kho. Vim rau qhov ntev tshem tawm "Allopurinol" (xyuas ntawm cov kws kho mob paub meej tias nws) yog tsis pom zoo rau siv nyob rau hauv cov neeg uas muaj mob raum tsis ua hauj lwm. Nyob rau hauv cov neeg mob uas fwm raum excretory muaj nuj nqi cumulation yog tsis cai.

"Allopurinol": indications rau kev siv

Xyuas cov kws kho mob muab tshuaj tshuaj no hais tias nws yog feem ntau zoo thiab yog tsis txhaum nyob rau hauv tus neeg mob ntawm hyperuricemia (theem ntawm uric acid ib chav tsev ntim ntawm cov ntshav) nyob rau ntawm:

• gouty mob caj dab (gout);
• urate urogenital cov kab mob (nephropathy, urolithiasis);
• oncological cov kab mob ntawm cov ntshav;
• congenital anomalies ntawm lub enzyme system.

Nyob rau hauv tej rooj plaub, tej zaum siv cov tshuaj rau kev kho mob ntawm cov me nyuam urate nephropathy, uas nyob rau hauv lub keeb kwm yav dhau ntawm leukemia kho nyob rau hauv congenital kab mob txuam nrog impaired metabolism ntawm uric acid, theem nrab hyperuricemia txawv keeb kwm.

Nta ntawm cov tshuaj

"Allopurinol" ntsiav tshuaj (xyuas ceeb toom ntawm nruj ua raws li cov tswv yim pom zoo ntawm cov tshuaj) yog npaum li cas tom qab ib tug noj mov, lawv yog los ntawm tsis txhais tau tias tsis yooj yim sua rau nws xo, tab sis, theej lawv tag nrho haus thiab haus dej haus tsawg kawg yog ib lub khob ntawm cov dej sov so.

Cov neeg noj cov tshuaj no, koj yuav tsum nco ntsoov saib xyuas lawv cov kev noj haus, thiab nyob rau hauv cov ntaub ntawv ntawm kev ua yuam kev nyob rau hauv cov khoom noj tsim nyog yuav tau kho nws ntau npaum, tiam sis tsuas yog nyob rau hauv lub saib xyuas ntawm tus mus kawm tshwj xeeb.

Cov tsim nyog koob tshuaj los kho "allopurinol" tshuaj no yog txiav txim siab nyob rau hauv cov ntsiab lus ntawm uric acid nyob rau hauv cov hlab ntsha. Feem ntau, nws yog hom twg los ntawm 100 mus rau 300 mg rau ib ib lub sij hawm "allopurinol" kev npaj. Xyuas ntawm cov neeg mob thiab cov kws kho mob hais txog qhov no dosing zoo, raws li cov tshuaj no yog noj ib zaug xwb ib hnub twg.

Gout txoj kev kho pib nrog lub sij hawm ntawm 100 mg ntawm cov tshuaj ib hnub ib zaug. Nyob rau hauv cov ntaub ntawv ntawm tsis muaj miv nyuas siv zug thiab pluag txos uric acid ntau npaum yog maj zog (los ntawm 100 mg txhua txhua ob los yog peb lub lis piam), ua rau zoo kho kuaj nyob rau hauv cov kev tswj ntawm uric acid. Nyob rau hauv xws li mob, qhov nruab nrab ntau npaum thiab tom ntej txij nkawm koob tshuaj yog hom twg los ntawm 200 mus rau 400 mg, tab sis nyob rau hauv tej lub sijhawm, cov tshuaj yuav ua tau mus rau 800 mg. Nyob rau hauv cov ntaub ntawv no, nws yog muab faib ua ob peb zaug ib hnub twg.

Nyob rau hauv appointing cov tshuaj rau cov neeg mob raum insufficiency yuav tsum tsom ntsoov rau cov creatinine clearance.

Contraindications rau "Allopurinol" los

Cov tshuaj yog ua rau cov neeg mob uas muaj mob loj raum tsis ua hauj lwm, raws li zoo raws li cev xeeb tub thiab lactating. Nws kuj tsis pom zoo rau cov tshuaj rau cov neeg mob muaj ib tug tsis haum cov tshuaj tiv thaiv los yog npau taws me ntsis mus rau ib los yog ntau tshaj Cheebtsam ntawm cov kev npaj. Nws yog txwv tsis pub siv cov tshuaj nyob rau hauv cov neeg mob uas borderline theem ntawm uric acid nyob rau hauv cov ntshav ntshav, vim hais tias ntawm nws cov txo nrog kev vam meej yuav ua tau tiav los kho kev noj haus.

"Allopurinol": phiv

Xyuas ntawm cov neeg mob uas siv cov tshuaj rau cov thawj lub sij hawm, qhia tias nws yog feem ntau heev tau exacerbation thiab muaj zog cov tsos mob ntawm gout nrog lub rov tshwm sim ntawm lub thiaj li hu ua tawm tsam. Tab sis qhov no luv luv-term phenomenon, thiab nws tsis yog tsim nyog yuav ntshai txaus yuav tsum txhob muab txoj kev kho. Tab sis nyob rau hauv cov ntaub ntawv ntawm tej pob, tsis xis nyob los yog uas ploj lawm thaum ntxov tej yam tshwm sim uas koj yuav tsum tam sim ntawd qhia rau koj tus kws kho mob. Nyob rau hauv no txoj kev ntawm "Allopurinol" yuav tsum tau nres sai li sai tau, thiab raws li lub disappearance ntawm cov tsos mob ti teg taw yuav rov muab cov tshuaj, tab sis rau ib tug tsawg koob tshuaj (los ntawm 50 mg). Nkag yuav tsum tau ua nyob rau hauv lub nyob ze saib xyuas ntawm tus kws kho mob thiab nyob rau hauv ib tug compartment.

Ntawm cov kev phiv tshuaj ntawm poob siab system thiab ntau dua puas siab puas ntsws zog tej zaum yuav ua rau kev nyuaj siab. Nyob rau hauv ib feem ntawm kev loj hlob ntawm kev tsim txom ntawm cov hlwb pob txha hematopoietic system yog tsis tshua cai nrog rau cov tshwm sim ntawm thrombocytopenia, aplastic anemia.

Thaum tau txais cov tshuaj tej zaum yuav tsim metabolic mob li ntshav qab zib, theem ntawm fatty acids nyob rau hauv cov ntshav ntshav.

Cardio-leeg tshav system yuav tsim tawg, bradycardia.

Lub zaus kev phiv tshuaj mus rau yeeb tshuaj yog nce nyob rau hauv lub xub ntiag ntawm lub raum tsis ua hauj lwm nyob rau hauv ib tug neeg mob.

Tso daim ntawv thiab ntau npaum

"Allopurinol" muaj nyob rau hauv cov ntsiav tshuaj daim ntawv (30 los yog 50 pcs. Nyob rau hauv pob) nyob rau hauv ib tug ntau npaum ntawm 100 los yog 300 mg ntawm active ingredient ib ntsiav tshuaj. Nyob rau hauv lub domestic kev ua lag luam muaj "Allopurinol Sandoz 300". Xyuas ntawm nws zoo, raws li cov tshuaj nyob rau hauv ntau npaum yuav muab ib zaug xwb ib hnub twg, zoo negates tau nco lub txais tos ntawm cov tshuaj.

Lom thiab tshuaj overdose

Lom tsis tshua cai, tab sis muaj mob ib zaug xwb koob tshuaj ntawm 20 grams ntawm cov tshuaj. Nyob rau hauv cov ntaub ntawv no, nej yuav muaj kev nram qab no cov tsos mob: kiv kiv taub hau, ntuav, xeev siab, raws plab. Nyob rau hauv lub raum insufficiency, thiab tas mus li thawj coj ntawm siab koob tshuaj ntawm cov tshuaj muaj cai mob loj ntawm intoxication nyob rau hauv daim ntawv ntawm cov kub taub hau, kab mob siab, mob raum tsis ua hauj lwm.

Kev kho mob ntawm mob raug kuab lom thiab overdose, symptomatic, aimed ntawm accelerating lub tshem tawm ntawm cov tshuaj los ntawm lub cev. Tsis muaj ib yam tshuaj. Kom sai feem ntawm cov tshuaj los ntawm lub cev lim ntshav txoj kev yog zoo detoxification.

Xyuas

Muab lub fact tias lub sij hawm ntawm tsub zuj zuj ntawm cov tshuaj nyob rau hauv cov ntshav (ntawm ib tug concentration txaus muab ib tug kho txiav txim) yog ib tug nruab nrab ntawm ib lub lim tiam, cov neeg mob kev txom nyem los ntawm gout, yuav tsum tau ua ntawv thov suab lub neej "allopurinol". Xyuas ntawm cov kws kho mob yog unambiguous: cov tshuaj muaj proven nws tus kheej zoo. Tab sis qhov no yog tsis yog ib tug "txuj ci tseem ceeb ntsiav tshuaj" uas yuav muaj ib tug haus dej thiab tsis nco qab txog tus mob. Gout - nws yog ib tug es txoj kev ntawm lub neej es tsis ib tug mob tus kab mob. Tab sis nws yog tus "Allopurinol" yuav pab tau tswj rau theem ntawm kev lactic acid thiab tiv thaiv kom txhob lub aggravation ntawm tus kab mob thiab nws ntxiv kom vam meej.

Nyob rau hauv cov nqe lus ntawm kev kab ntsab, cov lo lus uas "Allopurinol" tshuaj lus teb los ntawm cov kws kho mob kuj zoo, vim hais tias nyob rau hauv feem ntau tus neeg mob yuav tsum tau coj ib hnub ib zaug tshuaj noj. Qhov no minimizes qhov tshwm sim rau uas ploj lawm lub txais tos ntawm cov medicament thiab, li no, tsub kom lub efficiency ntawm txoj kev kho.

xaus

Yog li, lub ntsiab tshuaj rau gout - "Allopurinol". Xyuas cov tub txawg thiab cov neeg mob, qhov no txhais tau tias kev, zoo, thiab qhov no muaj tseeb nrog qhov efficiency ntawm lub medicament nrog kev kho mob ntawm gout thiab uric acid metabolism ntshawv siab. Tsaug rau qhov kev siv ntawm cov tshuaj, ib tug zoo kawg tooj ntawm cov neeg mob tau kev cia siab los txo cov teeb meem ntawm cov ntshav qab zib.