Qhov tseeb tiam ntawm statin tshuaj: zoo, nqi, xyuas

Class statin yeeb tshuaj tau tsim raws li ib tug txhais tau tias los txo tus nqi ntawm cov ntshiab cov roj cholesterol thiab txo mob plawv. Rau ib ntev lub sij hawm soj ntsuam thiab cov kws kho mob ua hauj lwm nrog cov tshuaj, "Lovastatin," "Pravastatin" "Simvastatin", "Fluvastatin." Tau ces tsim "Atorvastatin" thiab "Rosuvastatin" - yog qhov tseeb tiam ntawm statins, los yog es, qhov zoo tshaj tshuaj nyob rau hauv no. Nws tseem yog tam sim no raws li nram no los tsim tshiab, hais tias yog txawm ntau muaj kev ruaj ntseg thiab zoo statins, cov uas nrov tshaj plaws belongs rau lub "pitavastatin."

General pharmacological yam ntxwv ntawm statins

Tag nrho cov statins poob mus rau hauv cov qeb ntawm cov tshuaj uas cuam tshuam rau lipid metabolism nyob rau hauv tib neeg lub cev. Lub anatomical Therapeutic Tshuaj Classification System tshuaj lawv xaiv code S10AA thiab txheeb inhibitors ntawm HMG-CoA reductase. Inhibiting kev ua ntawm no enzyme, lawv txhob cuam tshuam txog lub synthesis ntawm cov roj uas txhaws, ntshiab txo nws npaum li cas. statins Qhov kev ua tso cai rau kom tau pom zoo ntau tsawg-density lipids nyob rau hauv cov ntshav.

Cov los ua rau nws tau txo tus nqi ntawm txoj kev loj hlob ntawm atherosclerotic cov quav hniav. Tsis tas li ntawd cov tshuaj tiv thaiv tau nws tshwm sim. Txawm yog hais tias nws yog muaj nyob rau hauv qhov tseem ceeb nyhuv ntawm statins: lawv tswj lub endothelium ntawm atherosclerotic cov quav hniav, nyob rau hauv no hais txog, txo qhov yuav ua rau coronary thrombosis, kuj los ntawm ib tug txawv mechanism tshaj antiplatelet txoj kev kho. Ntxiv mus, lub neej coj siv ntawm cov nyiaj no tso cai txawm ntau los txo qhov yuav ua rau koj lub plawv nres. Vim hais tias statins ntsia tus nqi nws yog tag nrho txhaum.

Tshwj xeeb statins kev faib

Muaj ntau ntau le caag los lub division rau hauv cov chav kawm ntawm cov tshuaj. Lawv yuav pom nyob rau hauv cov nqe lus ntawm cov nta synthesis. Tsis tas li ntawd, txij li thaum cov kev kho mob los ntawm ntau yam statins yuav tsum tau qee nyob rau hauv txawv koob tshuaj yog tsim nyog yuav ua kom paub ib tug faib raws li pom zoo noj tshuaj npaum cas. Ib suam ntawm tiam zoo li no:

• Kuv tiam "Simvastatin", "Pravastatin", "Lovastatin".
• II tiam, "Fluvastatin."
• III tiam "cerivastatin," "Atorvastatin".
• Tiam IV "pitavastatin," "Rosuvastatin."

Tag nrho cov statins raug muab faib mus rau hauv dag tsim los ntawm raw cov ntaub ntawv, thiab tej yam ntuj tso. Cov yav tas muaj xws li "Lovastatin," "Pravastatin" thiab "Simvastatin". Khoom cua tshuaj yog tas: "Fluvastatin," "Atorvastatin", "Rosuvastatin" thiab "pitavastatin."

Ib suam ntawm statins nyob rau hauv koob tshuaj nyob ntawm seb daim ntawv thov

Tag nrho cov chav kawm ntawv ntawm cov tshuaj, xws li qhov tseeb tiam ntawm statins, intelligently muab faib mus rau hauv uas tsis muaj koob tshuaj (8 mg), srednedoznye (10-40 mg) ntawm siab (40-80 mg). Nyob rau hauv kev:

• high-inflammatory tshuaj ( "atorvastatin", "Lovastatin" "Fluvastatin");
• srednedoznye tshuaj ( "simvastatin", "pravastatin", "Rosuvastatin");
• tsawg koob tshuaj tshuaj ( "pitavastatin").

Qhov no kev faib qhia tau ntawv thiab lawv kho ntau yam. Nyob rau hauv kev, high-tshuaj muaj ib cov nyhuv hauv high nqi, thaum zoo taus. Srednedoznye tshuaj, tab sis "rosuvastatin" tsawg tsawg zoo taus nyob rau high school koob, tab sis muaj ib tug zoo zoo.

Srednedozny statin "Rosuvastatin" yuav muab nyob rau hauv ib tug siab ntau npaum (80 mg), Yog hais tias tsim nyog, tab sis yog vim hais tias ntawm ib tug txaus tiav yuav txo tau ntawm tag nrho cov roj uas txhaws taus thiab tsawg-density feem uas yog feem ntau tsis yuav tsum tau. "Pitavastatin" thiab tsis yuav tsum tau cov lo lus uas nyob rau hauv yam tsawg kawg nkaus tus nqi, vim hais tias ntawm yog dab tsi cov kev txaus ntshai ntawm kev phiv tshuaj ntau lub sij hawm tsawg dua hais tias ntawm lub chav kawm ntawv counterparts.

Lub keeb kwm ntawm txoj kev loj hlob thiab cov kev taw qhia ntawm statins

Keeb kwm ntawm statins yog ib co teeb meem. Chiv, lawv txoj kev loj hlob yog heev hampered los ntawm cov tsis muaj kev txawj ntse ntawm cov roj uas txhaws metabolism thiab yuav tsim atherosclerosis, nyob ntawm seb lub theem ntawm cov ntshav lipids. Ntxiv mus, ib zaug tsim gopoholesterinemicheskie txhais tau hais tias inhibit microflora nyob rau hauv haiv neeg ntawm pwm, npaj kom tau cov ntshiab penicillin. Qhib ntawm cholesterol-txos kev txiav txim ntawm ib tug xov tooj ntawm tej yam uas ua los ntawm fungi, thiab muaj enabled txoj kev tshawb no ntawm statins.

Nws los ua tus thawj statin, compactin, thiab tsis nkag tau rau hauv cov kev soj ntsuam xyaum vim muaj ntau kev tsis sib haum kev xav txog nws cov teebmeem. Nws twb cais los ntawm cov kab lis kev cai ntawm Penicillium cetrinium. Ces, los ntawm ib tug kab lis kev cai ntawm Monascus ruber yog raug rho tawm monacolin K, patented nyob rau hauv Lub ob hlis ntuj 1979. Nyob rau hauv Lub rau hli ntuj 79th patented thiab mevinolin, uas tom qab pib muaj lub npe "Lovastatin". Qhov no tshuaj yog siv nyob rau hauv lub tsev kho mob, tom qab nws tau raug cais los yog tsim los ntawm qhov tseeb tiam ntawm statins.

Ib tug ntau ntawm tawm tsam views statins inhibited qhov kev loj hlob, tom qab uas nws tau txiav txim siab los ua kev cai loj-scale raug soj ntsuam. Rau hnub tim, qhov loj tshaj plaws thiab feem ntau pab tau yog txoj kev tshawb no ntawm Scandinavian Simvastatin ciaj sia taus Study. Zog nws lub npe yog «4S». Nws yog tag nrho refuted tau carcinogenic kab mob tshuaj cov thawj coj, thiab ua pov thawj hais tias lawv siv ho tsub kom lub neej expectancy thiab thiaj li muaj cov xwm txheej ntawm cov mob coronary pathologies.

Abstracts rau cov kev pab ntawm statins

Thaum thawj zaug concentration ntawm tag nrho cov roj uas txhaws taus ntawm 7.4 mmol / l, statin txoj kev kho thiab kom ua tau ib theem ntawm 5.4 mmol / L ho thiaj li txoj kev pheej hmoo ntawm tuag plawv txheej xwm los ntawm 40% tshaj tom ntej 5 xyoo. Ib tug xov tooj ntawm lwm cov kev tshawb fawb tau qhia tias txos tag nrho cov roj uas txhaws theem tsuas yog 1 mmol / L los ntawm ib tug thib tsib thiaj li yuav ua rau muaj mob hlab ntsha thrombosis thiab chaw pib lub plawv nres los yog hlab ntsha tawg.

Xav lub statins, lub pros thiab cons ntawm cov uas hais lus ib tug ntau ntawm cov tub txawg thiab cov neeg mob, peb yuav to taub tej kev tseeb no: koj yuav muab cov tshuaj raws li thaum ntxov raws li lub hnub nyoog 40 xyoo thiab laus dua, thiab kom txhob muaj kev txaus ntshai ntawm kab mob plawv - ib tug muaj kuab tactic ntawm tom neej. Thiab txij li thaum statins nqi yog heev puas siv tau, cov tshuaj muaj proven zoo, yuav tsum noj tsis muaj prejudice rau nws tus kheej kev siv nyiaj. Ntawm cov hoob kawm, qhov tseeb tiam ntawm statins yog cov ntau ntau kim, txawm hais tias tus tib "Rosuvastatin" Nyob rau hauv hauv paus ntsiab lus, nws yog kim heev rau tus neeg mob. Thiab nws yog lub feem ntau pheej yig daim ntawv npaj "Merten".

Comparative yam ntxwv: Pros thiab Cons

Soj ntsuam statins, thiab tiv thaiv lawv hais lus heev tsuas. Cov lus sib cav "rau" yog ib tug feature ntawm lawv kho qhov kev txiav txim: yuav txo tau ntawm cov ntshav roj uas txhaws taus thiab tsawg-density fractions, tiv thaiv kev pheej hmoo ntawm mob xwm txheej thiab pab nyob rau hauv lawv cov kev kho mob. Txawm li cas los, cov tshuaj xws li statins, tseem muaj contraindications. Muaj phiv, kho tawm tsam hauv daim ntawv thov.

Thaum txoj kev kho nrog statins txoj kev pheej hmoo ntawm myopathy. Nws zaum kho hom haum xeeb los ntawm inhibition ntawm cov synthesis ntawm cov roj uas txhaws, uas yog yuav tsum tau leeg. Tus zaus ntawm no cov nyhuv yog tsis tshua muaj tsis tshua muaj, txawm tias nws tau nce los ntawm coadministration nrog rau lwm cov hypolipidemic agents. Muaj kuj yog ib tug uas muaj feem yuav mob siab ua cancer pathology, txawm hais tias qhov tshwm sim ntawm xws li ib tug kab mob, raws li qhia los ntawm tsis ntev los no kev tshawb fawb, tsis tshua muaj tsis tshua muaj. Nyob rau tib lub pov thawj thiab lub fact tias cov mob cancer tau provoked los ntawm lwm yam. Li no, nyob rau hauv kev npaj ntawm cov "statins" contraindications yuav tsum txwv tsis pub co-thawj coj ntawm cov tshuaj nrog rau lwm cov neeg uas txhawb ib tug txo nyob rau hauv lub concentration ntawm roj hlwb.

Tus nqi ntawm qhov tseeb tiam ntawm statins

Nyob rau qhov tseeb tiam ntawm statins txawv tus nqi, txawm hais tias lawv cov teebmeem uas muaj nqis them rau. Lwm lo lus nug yog tsuas yog hais tias qhov kev tshwm sim ntawm lawv ua yuav ua tau tiav nrog rau cov kev siv cov cheaper analogues chav kawm ntawv ua ntej lawm tiam. Nyob rau hauv kev, feem ntau statin Tiam IV "Rosuvastatin" nqi yog kwv yees li raws li nram no:

• 600 rubles rau ntsiav tshuaj ntawm 40 mg;
• 400-450 rau cov ntsiav tshuaj 20 mg;
• 300-350 rau 10 mg ntsiav tshuaj;
• 200 rubles 5 mg.

Cov pob muaj 30 ntsiav tshuaj, txaus rau ib lub hlis ntawm kev kho mob, thaum lub sij hawm txhua hli kev kho mob "pitavastatin" cov nqi kwv yees li raws li nram no:

• 1 mg ntsiav tshuaj raug nqi txog 700-750 rubles;
• Ntsiav tshuaj 2 mg - txog 1000 rubles;
• ntsiav tshuaj 4 mg - txog 1500 rubles.

Cov kev xaiv ntawm "Pitavastinom" thiab "rosuvastatin" yog raws li nyob rau hauv plaub no: nqi tshaj, tus nqi uas yuav txo tau ntawm tsawg-density lipoprotein, high-density lipoprotein nce fullness, kev ruaj ntseg. Cov kev ceev ntawm tej roj uas txhaws taus thiab ua HDL, raws li zoo raws li qhov zoo tshaj plaws nqi zoo "Rosuvastatin", thaum raws ntau ruaj ntseg yog lub "pitavastatin."

Last ob zaug raws li kim nyob rau hauv kev sib piv nrog "rosuvastatin". Cuaj kaum, muaj yog tau siv lwm yam, pheej yig dua statins. Qhov tseem kev lag kev luam kev zoo yav tas los lawm "Simvastatin". Tam sim no nws twb hloov los ntawm "Atorvastatin", uas yog tu ncua hloov los ntawm "rosuvastatin" (cov nqi yuav tas caij nplooj ntoos zeeg). Thiab yog hais tias statins tseeb tiam nqi unaffordable rau cov neeg mob, nws yog tsim nyog los xav txog lub tseem kho "atorvastatin" los yog "Simvastatin". Los ntawm txoj kev, feem ntau cov kev tshawb fawb ua nrog "atorvastatin".

Cov lus sib cav nyob rau hauv dej siab ntawm cov statins neeg laus

Yav tas los, clinicians yog tsis kam mus muab statins rau cov neeg mob laus tshaj 75 xyoo. Qhov ua rau ntawm yam nram qab no:

• txais tos, ntawm ob peb lwm cov chav kawm ntawm cov tshuaj;
• kev sib nrig sib kam muab ib tug tub kawm uas muaj cov tshuaj;
• tsis muaj los yog tsis muaj komplaentnost kev kho mob;
• lub kam ntawm cov neeg mob yuav tau lawv tus kheej statins thiab siv lawv vim hais tias ntawm cov tsis muaj kev nkag siab ntawm lawv cov teebmeem.

Ib tug xov tooj ntawm cov kev tshawb fawb nqa tawm nrog "Simvastatin" "Pravastatin" thiab "atorvastatin" pom ib tug tseem ceeb txo nyob rau hauv lub neej no rau cov neeg mob laus tshaj 75 xyoo. Ntxiv mus, lub txo nyob rau hauv lub neej no yog txawm siab tshaj uas ntawm cov neeg mob nyob rau hauv lub hnub nyoog 55-65 thiab 65-75 xyoo. Vim hais tias rau cov tshuaj ntawm no hauv chav kawm ntawv (statins) cov lus los ntawm cov kws txawj kom meej meej qhia ib qhov tseeb.

Cov tshuaj no yuav tsum tau noj tom qab nyob rau hauv lub neej tsis hais seb muaj yav tas los mob plawv mob. Thiab cov neeg mob uas yog tiag tiag teeb meem tseem ceeb los txo cov kev pheej hmoo ntawm nws txoj kev tuag los ntawm myocardial infarction los yog mob stroke, koj yuav tsum to taub tias yog hais tias cov tshuaj yog zoo thiab ruaj ntseg, nws yog twv yuav raug hu muaj nqis noj. Tshwj xeeb tshaj yog hais tias kev kho mob nrog statins tau ua ntau siv tau, thiab yuav muaj mus ntxiv xws li.

Nta xyuas rau qhov tseeb tiam ntawm statins

Cov neeg mob cov lus nyob rau hauv nrug muaj feem luj qhov zoo tshaj ntawm ib tug generic statins yog tsis indicative, vim hais tias lawv tsis tau muaj teeb meem loj cov kev hloov los ntawm kev noj cov tshuaj. Kev txhim kho cov ntshav lipid profile tsis tshwm nyob rau hauv lub xeev kev kho mob thiab twb tsis muaj lwm cov tsos mob. Nws paub xwb lipid profile. Vim hais tias thaum ntsuam statin ntse ntsuav ua txoj kev ntsuam xyuas cov kws txawj. Thiab hais txog cov kev npaj los nyob rau hauv uas lub active ingredient yog pitavastatin, lub zos cov kws txawj tsis tau teb.

Nyob rau hauv soj ntsuam xyaum nyob rau hauv lub CIS "pitavastatin" vim hais tias ntawm tus nqi thiab vim hais tias ntawm lub xub ntiag ntawm "rosuvastatin" thiab nws cov Generics tsis thov. Nyob rau hauv kev npaj "rosuvastatin", uas yog qhia saum toj no, tus ceev txiav txim: lipid profile normalized 1-2 lub hlis. Lub "atorvastatin" yog lub sij hawm thiab ib tug ib nrab sij hawm ntau. Tsis tas li ntawd generic "rosuvastatin" kev ruaj ntseg, txij thaum lub ob hom yog metabolized los ntawm tus cytochrome. Thaum lub caij, cov ntaub ntawv no yog muab los ntawm cov lus ntawm cov kws txawj, nws plays lub luag hauj lwm tseem ceeb heev nyob rau hauv cov kev xaiv ntawm statin nyob rau hauv ib cov kev soj ntsuam lub sijhawm.

Cov kev xaus ntawm qhov tseeb tiam ntawm statins

Tshuaj "pitavastatin" thiab "Rosuvastatin" yog cov heev tshaj plaws ntawm cov neeg sawv cev ntawm lub statin chav kawm ntawv, rau cov uas ib tug loj lub cev ntawm cov pov thawj sau. Lawv los yog feem ntau zoo ib yam li cov uas nyob hauv "atorvastatin", tab sis muaj cov sib txawv. "Pitavastatin" thiab "Rosuvastatin" cia mus cuag lub hom phiaj roj ntau ntau, thiab tsis muaj kev ceev lipoprotein nyob rau hauv ib tug tsawg dua ntau npaum tshaj li tus "atorvastatin".

Nyob rau hauv tas li ntawd mus rau saum toj superiority statins tseeb tiam yog ib qho tseem ceeb thiab yog lwm yam. Namely, nyob rau hauv cov kev kho mob ntawm "pitavastatin" thiab "rosuvastatin" pom ceev normalization ntawm cov ntshav lipids thiab tshem tawm homocysteinemia. Qhov no yog ib qho tseem ceeb raws li nyob rau hauv cov ntaub ntawv ntawm mob coronary kab mob, thiab nyob rau hauv cov neeg mob uas mob coronary mob, txhais los ntawm coronary atherosclerosis. Kev ruaj ntseg ntawm kev siv ntawm statins siab tshaj kardioform acetylsalicylic acid. Cuaj kaum, tus xub ntiag ntawm contraindications txwv tsis pub lawv siv rau tej neeg mob pejxeem (saib. General contraindications).

formulation piv txwv

Tshuaj uas muaj "Rosuvastatin" muaj nyob rau hauv cov nram no pauv npe: "AKORT", "Rozistark", "Rozukard", "Rozart", "Merten", "Rozulip", "Roxer", "Rustor", "Tevastor". Tag nrho cov ntawm cov tshuaj yog generic "Crestor" uas tau los ua tus thawj rosuvastatin. Tshuaj, nyob rau lub active tshuaj yog pitavastatin, sau npe raws li «Livalo». Nws Generics yog «Pitavas» thiab «Pivasta». lawv tsis tshwm sim nyob rau hauv lub CIS, txawm hais tias sau npe nyob rau hauv lub Pharmacopoeia.

txoj kev

Nyob rau hauv raws li cov chav kawm ntawv ntawm cov tshuaj los thiab tsom xam ntawm cov hauj lwm zoo ntawm lawv cov kev siv, kev siv cov statins yog warranted rau stabilizing atherosclerotic cov quav hniav thiab tiv thaiv tau nws lim. Lawv kuj siv los txo cov kev siv ntawm atherosclerosis, rau cov lipid profile ntawm cov ntshav ntshiab. Raws li ib tug tshwm sim, qhov no hauv chav kawm ntawv ntawm cov tshuaj yog tseeb tsim nyog nyob rau hauv Cardiology. Thiab qhov zoo tshaj ntawm qhov tseeb tiam statins twb zoo txhais tau tias ntawm kev tiv thaiv ntawm neeg tuag taus coronary thrombosis.