"Levodopa / benserazide-Teva": cov lus qhia rau kev siv, analogs thiab xyuas

Yuav ua li cas yuav hloov tau cov tshuaj no raws li "L-Dopa / benserazide"? Analogues cov tshuaj no yuav tsum tau tham tom qab nyob rau hauv tsab xov xwm. Peb kuj yuav nthuav lub pharmacological yam ntxwv ntawm qhov cuab tam, nws cov daim ntawv ntawm kev tso tawm, indications thiab cov hau kev ntawm kev siv.

Form, muaj pes tsawg leeg, ntim

Lub medicament "levodopa / benserazide-Teva", cov kev qhia ntawv yog xa tuaj nrog nyob rau hauv ib tug cardboard lub thawv yog tawm nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, ntim rau hauv hwj ntawm 30, 20, 60 los yog 50 daim. Lub ntsiab yam khoom uas ntawm cov tshuaj levodopa thiab benserazide protrude. Nrog kev xav txog ntxiv Cheebtsam, lawv muaj xws li: mannitol, calcium hydrogen phosphate (anhydrous), MCC, crospovidone, pregelatinized maize starch, colloidal silicon dioxide, povidone K25, magnesium stearate, thiab ib tug colorant liab ferric oxide.

pharmacological yam ntxwv

Kev npaj "levodopa / benserazide" nruab nrab yog cov chav antiparkinsonian neeg sawv cev uas muaj xws li nyob rau hauv nws muaj pes tsawg leeg cov decarboxylase inhibitor (peripheral) uas muaj ntxhiab L-amino acid thiab dopamine precursor.

Nyob rau hauv parkinsonism, dopamine yog tso tawm los ntawm lub basal ganglia nyob rau hauv tsis txaus ntau. Nws hloov yog nqa tawm los ntawm tau txais levodopa, uas yog ib tug metabolic precursor ntawm dopamine.

Qhov loj tshaj plaws ib feem ntawm no nyob rau hauv lub peripheral ntaub so ntswg yog hloov dua siab tshiab rau hauv dopamine, uas tsis koom nrog nyob rau hauv lub antiparkinsonian nyhuv, txij li thaum nws tsis txeem los ntawm cov ntshav-hlwb barrier, thiab tseem yog ib lub luag hauj lwm rau feem ntau ntawm cov nyom tshua.

Lub kinetics ntawm yeeb tshuaj

Raws li kws txawj tuab cov tshuaj nyob rau hauv cov lus nug, los yog es, nws tig-txheej txheem? Levodopa nrog benserazide absorbed feem ntau nyob rau hauv cov hnyuv. Thaum tau txais cov tshuaj noj mus rau hauv lub ncov concentration yog mus txog tom qab txog 65 feeb.

Nws yuav tsum tau tshwj xeeb yog muab sau tseg tias haum ntawm cov ntsiab nyob rau intragastric pH indicators, As, raws li zoo raws li tus nqi ntawm feem ntawm pais plab txheem.

Thaum tau txais levodopa tam sim ntawd tom qab noj mov nws siab tshaj plaws nyob rau hauv concentration ntshav yog hais txog 30% tsawg dua, thiab cov twg haum - 15% tsawg dua.

Nyob rau hauv loj qhov ntau, cov tshuaj no yog muaj nyob rau hauv cov hnyuv, lub raum, thiab nplooj siab. Txawm li cas los, tsuas yog 1% nkag rau hauv lub hlwb.

ib nrab-lub neej ntawm cov tshuaj nyob rau hauv kev ntsuam xyuas, lub sij hawm yog peb teev.

Tsis zoo li levodopa, xws tivthaiv formulation li benserazide, tsis txeem tau cov BBB. Qhov no tshuaj yog sau nyob rau hauv lub ntsws ntaub so ntswg, raum, siab thiab hnyuv.

Thaum muab?

Tshuaj "Levodopa / benserazide" yog anti-Parkinsonistic. Yog li ntawd, nws yog advisable kom taw:

• parkinsonian syndrome (syndrome kos yog tshwm sim los ntawm antipsychotic yeeb siv tshuaj);
• Parkinson tus kab mob;
• nyob tsis tswm ob txhais ceg syndrome, xws li nyob rau hauv cov neeg uas muaj mob raum tsis ua hauj lwm uas yog nyob rau hauv kev lim ntshav.

Bans siv

Seb puas muaj cov contraindications nyob rau hauv lub tshuaj "Levodopa / benserazide-Teva" (cov lus teb qhia hais tias lawv validity, peb xav txog hauv qab no)? Qhov no tshuaj yog txwv tsis pub kom taw:

• kev puas hlwb;
• npau taws me ntsis rau cov neeg ua hauj ntsiab;
• loj teeb nyob rau hauv lub endocrine system, raws li zoo raws li cov hlab ntsha thiab lub plawv;
• cov kab mob ntawm lub raum thiab lub siab, tab sis kev kawm ntawm nyob tsis tswm ob txhais ceg syndrome nrog ua ke tawm los lim ntshav;
• lactation;
• kaw glaucoma;
• thaum uas tig mus daim ntawv thov nonselective Mao inhibitors;
• cev xeeb tub;
• nyob rau hauv lub hnub nyoog ntawm 25 xyoo;
• ntawm kev ua me nyuam muaj hnub nyoog nyob rau hauv lub fairer pw ua ke, tsis siv txhim khu kev qha txoj kev pov.

"Levodopa / benserazide": trade lub npe, txoj kev ntawm daim ntawv thov

Yuav saib xyuas medicament yuav ua tau nyob rau hauv tej chaw muag tshuaj. Trade lub npe ntawm cov tshuaj suab zoo li "Levodopa / benserazide-Teva".

Nyob rau hauv dab tsi ntau npaum los siv rau cov neeg mob xam tau tias yog tshuaj? Kev kho mob ntawm cov txhais tau tias pib nrog ib tug tsawg koob tshuaj, uas yog maj zog (rau txhua tus neeg mob zuj zus).

Raws li cov kws txawj, koj yuav tsum tsis txhob siab koob tshuaj cov tshuaj no. Cov nram qab no dosing regimen yuav tsum raug xam tias yog raws li ib tug general pom zoo.

"Levodopa / benserazide", coj lus rau tsawg kawg ib nrab ib teev ua ntej los yog tom qab 65 feeb tom qab ib tug noj mov.

Cov neeg yav tas los noj no txhais tau tias, thaum pib ntawm txoj kev kho kom txoj kev siv cov 12.5 / 50 mg levodopa thiab benserazide plaub zaug ib hnub twg. Nrog zoo tolerability ntawm lub ntau npaum si los ntawm cov nyiaj tib txhua txhua peb hnub. Tom ntej titration yog nqa tawm nrog ib zaus ntawm 1 txhua txhua 30 hnub.

Feem ntau, cov kho nyhuv tom qab thawj coj ntawm cov tshuaj cai twb thaum tau txais 100 mg benserazide thiab 400 mg ntawm levodopa ib hnub twg.

Qhov siab tshaj plaws ntau npaum ntawm cov tshuaj ib hnub twg yog 800/200 mg ntawm levodopa thiab benserazide feem. Hais tias tus nqi ntawm medicament yuav tsum tau muab faib los ntawm 4 los yog ntau tshaj koob tshuaj. Yog li lawv yuav tsum tau muab faib thiaj li mus muab tus neeg mob nrog cov pom kho nyhuv.

Nrog rau txoj kev loj hlob ntawm kev phiv tshuaj yuav tsum nce lub koob tshuaj los yog tso tseg, los yog txo nws.

Cov tshuaj regimen ntawm cov tshuaj nyob rau hauv tshwj xeeb soj ntsuam lub sijhawm

Yuav ua li cas kuv yuav tsum tau coj cov tshuaj "Levodopa / benserazide"? Guest cov kws txawj qhia tias tus neeg mob muaj mob loj heev lub cev muaj zog hloov mus hloov los, txhua hnub koob tshuaj no noj tshuaj yuav tsum tau muab faib los ntawm ntau tshaj 4 nkag.

Nyob rau hauv cov laus hnub nyoog, ua rau kom ntau npaum yuav tsum muab qhov chaw maj mam.

Cov kev ntawm cov tshuaj nyob rau hauv cov me nyuam thiab cov tub ntxhais hluas yog tas.

Nyob rau hauv hepatic thiab lub raum tsis ua hauj lwm medicament koob tshuaj hloov yog yuav tsum tau.

Nrog rau txoj kev loj hlob ntawm txawj taw, tshwj xeeb tshaj yog nyob rau hauv lub tom qab ua sawv ntawm kev kho mob, nws yog pom zoo kom txo tau cov tshuaj. Tib yam siv rau lub undesirable txim ntawm lub CCC.

Cov tsos mob ntawm overdose

Txais tos "Levodopa / benserazide" high koob tshuaj ntawm cov tshuaj, txhais, uas yuav tsum tau hais hauv qab no, yuav ua rau cov tsos mob xws li xeev siab, lus, tsis taw ntawm ib tug pathological xwm, insomnia, ntuav, tsis meej pem. Nws yuav tsum tau muab sau tseg tias cov kev loj hlob ntawm tej tsos mob tej zaum yuav raug ncua vim qeeb haum ntawm cov tshuaj los ntawm cov hnyuv.

Rau cov kev kho mob ntawm tej yam kev mob piav symptomatic txoj kev kho (tshuaj antiarrhythmic tshuaj, ua pa analeptic thiab neuroleptics), thiab tsis tu ncua saib xyuas qhov tseem ceeb heev functions ntawm lub cev.

sis

Tshuaj "Levodopa / benserazide" ua num ua ke nrog rau lwm cov tshuaj raws li nram qab no:

• Tau txais trihexyphenidyl thiaj li tus nqi, tiam sis tsis raws li ntawm haum ntawm levodopa.
• Antihypertensive tshuaj, opioids, neuroleptics thiab cov khoom uas muaj ib tug reserpine, inhibit qhov kev txiav txim ntawm lub piav medicament.
• Daim ntawv thov nrog antacids thiaj li raws li ntawm haum txhais tau tias nyob rau hauv kev saib xyuas los ntawm 32%.
• Metoclopramide tsub kom tus haum tus nqi ntawm levodopa.
• Nkag pyridoxine thiaj nyhuv ntawm antiparkinsonian tshuaj.
• Levodopa thiab benserazide tej zaum yuav tsis raug siv nyob rau hauv ua ke nrog uas tsis yog-xim Mao inhibitors.
• Saib cov tshuaj potentiates qhov kev txiav txim ntawm sympathomimetic.
• Levodopa thiab benserazide nrog rau lwm cov antiparkinsonian tshuaj pab ntshaw thiab undesirable los.

Cov ntaub ntawv

Ua ntej koj pib noj "Levodopa / benserazide" yuav tsum yauv mus ua ib tug tag nrho cov kev xeem. Qhov no yog vim lub fact tias muaj ib tug xov tooj ntawm cov kab mob nyob rau hauv uas ntawm kev siv lub cuab tam yuav tsum nrog huab ceev faj:

• Nyob rau hauv lub xub ntiag ntawm qhib lub glaucoma txoj kev kho tsis pib kom txog thaum tiav zoo ntawm tus neeg mob.
• Txwv tsis pub siv yeeb tshuaj dheev rho "halothane", raws li nws tej zaum yuav ua rau kom txoj kev loj hlob ntawm neuroleptic phem syndrome thaum lub sij hawm ua kom tsaug zog.

Nws yuav tsum tau muab sau tseg tias nyob rau hauv thaum pib ntawm nws kev noj tshuaj physiological tsis yuav tsum tau hloov los ntawm tus neeg mob. Nyob rau hauv no hais txog, nyob rau hauv lub chav kawm ntawm kev kho mob yuav tsum tau yuav tsum tau mus soj ntsuam tsis tu ncua los mus saib xyuas kom zoo tau hauj lwm ntawm tag nrho cov hauv nruab nrog cev.

Cov neeg uas muaj mob ntshav qab zib yuav tsum tau ob peb zaug ib hnub twg mus xyuas cov ntshav qabzib.

Tus nqi ntawm cov tshuaj thiab nws analogues / txhais

Yuav ua li cas ntau npaum li cov tshuaj no raws li "L-Dopa / benserazide-Teva"? Tus nqi ntawm cov tshuaj no nyob rau lub xov tooj ntawm cov ntsiav tshuaj ib pob. Nws feem ntau yog hom twg 600-1250 rubles.

Yuav ua li cas yuav muab suav hais tias hloov lub antiparkinsonian tshuaj? Nws lub ntsiab analogues thiab txhais muaj xws li cov nram qab no txhais tau tias: "Zimoks", "Duellin", "Isik," "Lac" "Dopar 275", "Carbidopa / Levodopa," "Sinemet", "Sindopa", "Tidomet", " Tremonorm ". Nws yuav tsum tau sai li sai tau muab sau tseg tias pharmacological yam ntxwv thiab cov hau kev ntawm kev siv cov tshuaj tej zaum yuav txawv muaj nuj nqis los ntawm cov saum toj no. Yog li ntawd, yuav hloov tau lawv, "levodopa / benserazide-Teva" yuav tsum tsuas tus kws kho mob pom zoo.

Tswv yim rau cov hauj lwm zoo ntawm cov tshuaj

Nws yog tsis muaj daim card uas Parkinson tus kab mob yog ib tug heev loj kab mob. Nyob rau hauv tas li ntawd, nws yog ib tug loj kev sib tw rau cov neeg mob thiab lawv cov txheeb uas sawv daws.

Raws li cov kws tshwj xeeb thiab cov kev pab thaum lub sij hawm kev kho mob tshuaj no muaj feem xyuam rau tag nrho cov neeg txawv. Tej zaum txawm nyob rau hauv cov nruj kev saib xyuas ntawm ib tug kws kho mob nrog ib tug ntev txais tos ntawm cov ntsiav tshuaj muaj cai nyob rau hauv tib neeg cov neeg mob txob taus thiab bouts ntawm aggression. Tsis tas li ntawd, sab tshua tshwm sim raws li hallucinations thiab kiv taub hau.

Los ntawm kev txo qhov ntau npaum nyob rau hauv ib co neeg mob cov tsos mob ntawm kev puas hlwb kev ntshawv siab yog disappearing, thaum lub cev muaj zog muaj nuj nqi yog tsis zoo. Txawm li cas los, nyob rau hauv lwm tus neeg mob, txawm tias tom qab ua tiav discontinuation ntawm cov tshuaj tag nrho cov puas siab puas ntsws mob. Nyob rau hauv tas li ntawd, lawv lub cev muaj zog muaj nuj nqi deteriorates ho.

Nyob rau hauv kev twb kev txuas nrog rau tag nrho cov saum toj no, peb yuav xyuam xim xaus uas nyob rau ntawm kev txais tos ntawm cov nyiaj tsim nyog yuav tsum tau npaj kom txhij rau txoj kev loj hlob ntawm kev mob loj tshwm sim tsis zoo, raws li hais saum toj no.

Raws li cov ntaub ntawv ntawm cov kws txawj, cov txheej txheem ntawm kev kho mob ntawm anti-Parkinsonistic kev npaj yuav muab qhov chaw tsuas nyob rau hauv cov nruj kev saib xyuas ntawm ib tug kws kho mob. Qhov no yuav tso cai rau txawm taug qab feeb hloov nyob rau hauv tus neeg mob tus mob rau cov hlab plawv system thiab psyche, thiab yog hais tias tsim nyog - yuav hnov mob nyob rau hauv ib tug raws sijhawm.