"Ospamoks": kev qhia. Xyuas, nqe indications rau kev siv

"Ospamoks" - lam antimicrobial active tshuaj yog amoxicillin - Cov neeg sawv cev ntawm ob peb aminopenicillins. Tsim nyob rau hauv nruab nrab-xyoo pua 20th, amoxicillin kuj yog ib qho ntawm feem nrov antimicrobial agents. Vim lub me me muaj pes tsawg tus ntawm cov nyom los yog teeb meem los, tab sis kuj vim lub bactericidal kev txiav txim nws tsi yog nrees Consolidated nyob rau hauv lub tsev kho mob. Nyob rau hauv lub qhov muag ntawm "amoxicillin" tshuaj nkag mus hauv lub xyoo 1972 xyoo, thiab ntev li ntev raws li nws yog ib tug yooj yim tshuaj tua kab mob nyob rau hauv cov kev kho mob ntawm pulmonary kab mob ua pa kab mob thiab kev pab txhawb nqa ntawm lawv cov mob loj heev thiab muaj mob loj tsawv khiav.

System khoom yam ntxwv

Nyob rau hauv kev npaj "Ospamoks" dav siv vim hais tias qhov tseem ceeb nta ntawm cov tshuaj tshuaj - amoxicillin. Nyob rau hauv lub cais ntawm cov tshuaj, nws yog hais raws li ib tug beta-lactam tshuaj tua kab mob ntawm semisynthetic keeb kwm. Nws aminopenicillin nrog ib tug dav spectrum ntawm antimicrobial kev ua si, nyob rau hauv kev sib raug zoo mus rau lub muaj kev ruaj ntseg macroorganism.

Nyob rau hauv kev npaj "Ospamoks" muaj ib pab pawg neeg ntawm cov chav kawm ntawv counterparts teej tug mus rau hauv qeb ingibitorzaschischennyh aminopenicillins. Nws yog zoo dua tshuaj tua kab mob, nws lub npe muaj raws li nram no: "Amoxicillin-clavulanate," "Ampicillin sulbactam." Lawv yog cov tseem muaj dav, tab sis yog siv ntau npaum li cas lug. Lub ntsiab kom zoo dua ntawm siv amoxicillin, lawv tshem tawm nws tseem ceeb tshaj plaws drawback - lub rhiab heev ntawm lub penicillins.

Lub antibacterial ua si ntawm lub tshuaj

Kev npaj "Ospamoks" (me nyuam thiab cov neeg laus) muab molecular ntxwv synthesis ntawm cov kab mob ntawm tes phab ntsa (peptidoglycan), muaj ib tug bactericidal kev txiav txim nyob rau hauv microbial cell. Raws li ib tug tshwm sim, cov tshuaj tshuaj "amoxicillin" tua cov kab mob. Wherein lub medicament active mas tiv thaiv Gram-zoo kab mob: pneumococcus, Enterococcus, Listeria. Tsis tas li ntawd, cov tshuaj "Ospamoks 1000" yog active tiv thaiv co kab mob - Clostridium sporogenous thiab peptostreptokokki.

Vim lub bactericidal kev txiav txim thiab kev ua txhaum ntawm cov txheej txheem ntawm synthesis ntawm peptidoglycan "Amoxicillin" yog ib tug broad-spectrum tshuaj. Txij li thaum peptidoglycan raws li ib tug yam ntxwv caij underdeveloped cell phab ntsa ntawm Gram-tsis zoo kab mob tiv thaiv uas cov tshuaj yog tseem dhia. Qhov tseem raug rau cov bactericidal nyhuv ntawm "Ospamoksa" Helicobacter, Neisseria, ua meningitis, tus kab mob salmonella thiab spore-txoj kev ua. Me ntsis tsawg raug rau amoxicillin hemophilia, Proteus, E. coli, spore-txoj kev Shigella, Vibrio cholerae thiab Neisseria uas ua rau gonorrhea.

Cov ntsiab pawg ntawm cov kab mob uas yog kho nrog cov tshuaj "Ospamoks" yog ib pab pawg neeg ntawm ua pa kab pathologies ntawm cov kab mob hauv paus chiv keeb. Tsis tas li ntawd, cov kab mob uas ua rau mob otitis media, kab mob mob ntsws, mob ntsws txaus thiab sinusitis yuav tsum tau lo lus uas peb "Amoxicillin". Qhov no tshuaj yog tseem muaj nyob rau hauv lub ternary daim duab ntawm eradication ntawm Helicobacter pylori thiab yog siv nyob rau hauv enteric kab mob, kab mob cov kab mob ntawm lub genitourinary system.

indications

Txuas mus rau lub tshuaj "Ospamoks 500" phau ntawv muaj cov lus qhia txog lub prophylactic siv. Nyob rau hauv kev, rau kev tiv thaiv ntawm cov kab mob mob tom qab ua tus txheej txheem diagnostic tshuaj yuav npaum li cas nyob rau hauv neeg laus 500 mg 3 lub sij hawm ib hnub twg rau 5-7 hnub. Ib tug zoo xws li cov sij hawm prophylaxis yog ntsia thiab tiv thaiv kom txhob mob tom qab kho hniav extraction. Tag nrho cov ntau yam ntawm indications raws li nram no:

• Ari: kab mob pharyngitis, tonsillitis, laryngitis, bronchitis, mob ntsws, mob ntsws txaus;
• pustular daim tawv nqaij kab mob: boils, carbuncles, pyoderma, streptoderma;
• kab mob ntawm lub sab mob txeeb zig (cystitis, urethritis);
• chlamydial kab mob thaum lub sij hawm cev xeeb tub;
• gonorrhea;
• typhoid kub taub hau, mob Lyme.

Pharmacodynamic txwv hauv daim ntawv thov

Qhov saum toj no indications no xwb, thiab nyob rau hauv Feem ntau, nyob rau hauv view ntawm tshuaj tua kab mob kuj, cov tshuaj muaj me ntsis cov nyhuv. Nws yuav siv tsis tau rau lub cais kev kho mob ntawm mob ntsws, pyelonephritis, lub taub dej khawb kab mob ntawm daim tawv nqaij thiab nqaij mos mos. Thaum lub caij, tag nrho cov tshuaj ntawm aminopenicillins los rhuav lub beta-lactamases kab mob nquag hloov los ntawm lub neej coj kev tiv thaiv penicillins: "Amoxicillin-clavulanate" thiab nws cov Generics.

Rau "amoxicillin" thiab, raws li, rau cov kev npaj "Ospamoks" qhia yoojyim xwb ib ob peb daim ntaub ntawv. Nws yog thawj-line tshuaj nyob rau hauv cev xeeb tub me nyuam nrog kab mob ntawm cov saum no. Tsis tas li ntawd, "Amoxicillin" thiab nws cov generic versions, xws li "Ospamoks", yuav siv tau rau cov muaj hnub nyoog nyob rau hauv cov me nyuam raws li cov zaj lus tim khawv. Siv sab nraum ntawm kis kab mob raws li ib tug tiv thaiv kev ntsuas nyob rau hauv cov me nyuam twb tsis muaj tswv yim muaj nuj nqis thiab yog txhob.

Tso daim ntawv thiab ntau npaum

Basic formulation "Ospamoks" npaj - ntsiav tshuaj uas muaj 500 thiab 1000 mg ntawm active ingredient. Qhov no yog feem ntau siv tshuaj tua kab mob kev xaiv uas yog qib siab rau cov neeg laus. Active tshuaj los ntawm cov ntsiav tshuaj nyob rau hauv lub plab yog dispersed thiab absorbed rau hauv cov ntshav. Tswv yim rau kub lug ntaub so ntswg thiab tob tob rau hauv lub interstitial qhov chaw thiab ncaj qha mus tua cov kab mob, accelerating tus txheej txheem ntawm rov qab los ntawm kis kab mob. Tsis tas li ntawd muaj nyob rau hauv cov hmoov formulations rau xyuas kev siv (hauv qab no).

Hmoov "Ospamoks" rau ncua kev kawm ntawv

Tsis tas li ntawd, nyob rau hauv view ntawm kev ruaj ntseg ntawm aminopenicillins nyob rau hauv cov me nyuam yog muaj xyuas formulations "Ospamoks" tshuaj. Raug tshem tawm rau cov me nyuam - yog ib tug zoo txoj kev ntawm daim ntawv thov ntawm cov tshuaj, uas tsis yuav tsum tau nqos tsiav tshuaj los yog ntsiav tshuaj. Thaum muaj hnub nyoog ntawm 5, thiab tej thaum mus txog rau 8 xyoo, cov me nyuam muaj teeb meem nqos khoom noj cov ntaub ntawv. Lub ncua kev kawm ntawv nyob rau hauv cov ntaub ntawv no yog cov feem ntau apt txoj kev enteral thawj coj ntawm ib tug antimicrobial tshuaj.

Npaj ib ncua kev kawm ntawv ntawm tus txheej txheem hmoov ntau npaum ntaub ntawv uas muaj 125, 250 thiab 500 mg rau ib 5 ml ntawm cov npaj sib tov. Nyob rau hauv tus txheej txheem ntim khoom kuj los dimensional vial 60 ml (los yog 100 ml rau cov tshuaj ntawm 500 mg / 5 mL) nrog ntsuas diav, nrog ib tug muaj peev xwm ntawm 5 ml.

Nta thiab dosing daim ntaub ntawv

Txuas mus rau lub tshuaj "Ospamoks" qhia yuav ob peb hom kev dosing nyob ntawm seb muaj hnub nyoog thiab lub raum muaj nuj nqi nyob rau hauv cov neeg mob uas nephrotic kab mob. Tus neeg laus npaum li cas (tshaj 16 xyoo) yog 1.5-2 g ib hnub twg. Lub dispersible ntsiav tshuaj ntawm 500 mg coj peb lub sij hawm ib hnub twg, 1000 mg - 2 lub sij hawm ib hnub twg rau 5-7 hnub.

Thaum muaj hnub nyoog ntawm 12 mus rau 16 xyoo pom zoo koob tshuaj 1000 mg ib hnub twg, uas yog ib tug plaub-lub sij hawm noj cov tshuaj ntawm ib koob tshuaj ntawm 250 mg, ob zaug los yog 500 mg. Muab cov yam ntxwv ntawm haum ntawm cov tshuaj thiab txo qhov yuav ua rau nws thaum noj nrog ib tug noj mov, nws yog pom zoo kom noj ib zaug xwb koob tshuaj 30 feeb ua ntej noj mov.

Siv cov tshuaj nyob rau hauv Pediatrics

Cov me nyuam ntau npaum nyob rau hauv lub hnub nyoog. Cov me nyuam mos thiab cov me nyuam mos mus txog ib xyoos muaj cai coj ib tug txhua txhua hnub koob tshuaj ntawm 250 mg. Khoom daim ntawv - hmoov rau ncua kev kawm ntawv 125 mg / 5 ml. Adopts cov nram qab no ntsuas diav 2 lub sij hawm ib hnub twg. Ib tug me nyuam uas muaj hnub nyoog 6 xyoo muaj cai coj qhov kev ncua npaj los ntawm "Ospamoks" standard npaj. Lub hnub koob tshuaj yog 375-500 mg: ncua kev kawm ntawv noj ntawm xab diav ob zaug thaum lub sij hawm ib hnub.

Los ntawm 6 mus rau 10 xyoo tus me nyuam yuav tau ua kom nws tus kheej tau tableted tshuaj "Ospamoks". Phau Ntawv Qhia txhais tau tias tau txais ib tug txhua txhua hnub koob tshuaj 750 mg. Ntsiav tshuaj ntawm 250 mg coj peb lub sij hawm ib hnub twg raws li tus kws kho mob pom zoo rau kev kho mob sij hawm. Yog hais tias vim lub xub ntiag ntawm lwm yam kab mob txuam nrog impaired nqos, slurry yog thov nyob rau hauv uas zoo sib xws noj tshuaj npaum cas. Nyob rau tib lub sij hawm nyob rau cov muaj hnub nyoog yog tsim nyog los saib xyuas txoj kev kho, kev luj xyuas ntawm cov hauj lwm zoo ntawm cov antimicrobial neeg saib xyuas thiab qhia kom paub txog kev phiv tshuaj.

Tshwj xeeb tshaj yog lub sab los ntawm cov tshuaj

Group tshuaj tua kab mob penicillin distinguished cov ntaub ntawv tsawg toxicity, txawm li cas los, yuav ua kom ua xua. Vim hais tias ntawm cov tshuaj lom muaj kev ruaj ntseg, rau qhov kev npaj "Ospamoks" qhia pub rau cov kev siv ntawm ib tug xyuas neonatal lub sij hawm. Ntxiv mus, nyob rau hauv cov neeg laus thiab cov me nyuam mos tshuaj tshuaj "amoxicillin" ua rau ib txhia sab tshua. Nyob rau hauv kev:

• kev tsis haum tshuaj raws li urticaria, conjunctivitis, rhinitis, angioedema, kub taub hau, eosinophilia, kws tsawg anaphylactic poob siab;
• Common phiv xws li mob taub hau, xeev siab, kiv taub hau, raws plab, nrog heev siv (ntau tshaj 15 hnub nyob rau hauv ib tug xov tooj ntawm cov kab mob);
• crystalluria, interstitial nephritis, tsim tsuas yog nyob rau daim ntawv thov ua ke nrog metronidazole;
• tiv thaiv lub keeb kwm ntawm tshuaj tua kab mob tej zaum yuav tsim superinfection ntawm cov kab mob los muaj ib tug ua kom tiav los yog tus txheeb ze kuj mus "amoxicillin";
• Thaum siv raws li ib tug me nyuam mos liab tej zaum yuav tsim raws plab, fungal keeb kwm.

Contraindications

Contraindication yog tom ntej cov ntaub ntawv yuav tsis haum rau aminopenicillin, mob mononucleosis, raws plab thiab kab mob ntawm ib qho twg ntawm cov hnyuv ib ntsuj av. Cov tshuaj tsis yog siv nyob rau hauv lub xub ntiag ntawm bronchial hawb pob, mob tus kab mob tsis muaj kab mob mob, lub nrhiav kom tau cov ua xua rau cephalosporins. Cov yav tas yog ib tug txheeb ze contraindication thiab ua tib zoo soj ntsuam, txij li thaum tus ntoo khaub lig kev tsis haum tshuaj rau aminopenicillin tshwm sim xwb nyob rau hauv 5-20% ntawm cov neeg.

Nta ntawm daim ntawv thov nyob rau hauv cev xeeb tub thiab lactating cov poj niam

Ib qho tseem ceeb nam ntawm tshuaj tua kab mob siv thaum lub sij hawm cev xeeb tub yog lawv tej zaum thiab tiag tiag toxicity. Npaj ntawm ib tug xov tooj ntawm cov penicillins tsis yog metabolized thiab tas nyob hauv cov thawj daim ntawv no. Qhov no txhais tau tias tsis muaj tshuaj lom los lawv ua. Tsis tas li ntawd, "Ospamoks" no yog hais nyob rau hauv relation mus tus kab mob hlwb thiab muaj tsis ntxim rau tib neeg lub hlwb.

Nyob rau hauv view ntawm cov nta, kev siv raug tso cai "amoxicillin" uas cev xeeb tub thaum twg theem nyob rau hauv cov kev kho mob ntawm tus kab mob raws li cov saum toj no indications. Ceeb tshaj, kwv yees li 30% ntawm cov khoom ntshav nyob rau hauv cov tshuaj diffuses los ntawm lub tsho me nyuam thiab mus rau hauv kev sib cuag nrog rau hauv lub cev ntawm lub fetus. Nyob rau hauv sim kawm thiab nyob rau hauv tej tshuaj soj ntsuam cov kev tshawb fawb uas muaj tib neeg tsis tau pov thawj tshuaj lom thiab teratogenic los 'Ospamoksa ".

Tsis tas li ntawd tsis muaj kev loj hlob ntawm teratogenic los nyob rau hauv cov tsiaj cov kev tshawb fawb thaum lub sij hawm cev xeeb tub. Txawm li cas los, thaum lub sij hawm lactation, nws yog ib qho tseem ceeb kom tsis txhob muaj tsawg ntawm cov tshuaj tua kab mob. "Ospamoks" yooj yim kis rau hauv niam cov kua mis thiab tus me nyuam ntawm lub plab yog absorbed rau hauv cov hlab ntsha. Nyob rau hauv view ntawm txoj kev pheej hmoo ntawm kev ua xua, raws plab thiab fungal plab hnyuv dysbiosis cov me nyuam nws yog pom zoo kom tsis txhob pub niam mis thaum lub sij hawm kev kho mob nrog ib tug tshuaj tua kab mob.

Class counterparts thiab generic tshuaj

Nyob rau hauv lub domestic kev ua lag luam nyob rau hauv niaj hnub thiab muaj kev nyab xeeb tshuaj "Ospamoks 250" Muaj txog ib lub teb tag nrho analogs coj txawv tus nqi. Lawv manufactured los ntawm ob peb lub tuam txhab uas muag thiab tsis txawv npaum li cas los ntawm "Amoxicillin" los ntawm lwm cov manufacturers. Nruj me ntsis hais tias, "Ospamoks 1000" yog cov generic, zoo li ntau lwm yam ntawm nws counterparts nyob rau pes tsawg leeg thiab qhov kev tso tawm daim ntawv no.

Nyob rau hauv cov ntsiav tshuaj preparations "Ospamoks" nqi yog hais txog 2/3 siab tshaj domestic counterparts, muab los ntawm JSC "Synthesis". nws tus nqi nyob rau hauv khw muag tshuaj yog hais txog 200 rubles. Rau tib lub efficiency ntawm kev xaiv yog tus nqi tau. Nyob rau hauv view ntawm lub tswv yim nta nyob rau hauv cov ntaub ntawv no, qhov tseem ceeb tshaj yog muab rau ntau domestic tshuaj, uas yuav raug muas cia li 30 rubles (20 pcs.).

kev tiv thaiv aminopenicillin

Me nyuam yaus analogs "Ospamoksa", "Augmentin" thiab "Hikontsil" nyob rau hauv daim ntawv ntawm cov hmoov rau qhov kev npaj ntawm cov tshuaj ncua kev kawm ntawv yog yus muaj los ntawm ib tug uas zoo sib xws efficiency li lub Lavxias teb sab analogs ntau mus siv cuag. Thiab lub breadth ntawm daim ntawv thov ntawm lub yav tas, xws li kev raug tsim, tsis txhob microbial kuj mus amoxicillin. Yog li ntawd, feem ntau siv yog tam sim no muaj kev tiv thaiv aminopenicillin clavulanate. Cov tshuaj tua kab mob (saib saum toj no rau lub npe) yog ntau haib nyhuv thiab ib tug dav antimicrobial spectrum.