Imidazoliletanamid pentandiovoy acid: pharmacological txiav txim, daim ntawv thov, analogues

Yog hais tias koj tus kws kho mob tau hais tias mob ib tug "kab mob", nws txhais tau tias koj yuav tau kho nws kom zoo. Ib tug haum loj pab pawg neeg ntawm peb cov khub pej xeem ntseeg tias tshuaj tua kab mob - qhov zoo tshaj plaws tshuaj rau tag nrho cov kab mob. Tu siab, nws yog ib tug misconception ua phem rau ib tug ntau ntau tshaj qhov tiag tiag kev mob nkees. Tshuaj tua kab mob tsuas yog active tiv thaiv kab mob kab mob, tab sis lawv yog powerless tiv thaiv kab mob.

Yuav ua li cas cov tshuaj ua hauj lwm zoo?

Muaj ib tug loj heev tooj ntawm cov tshuaj nrog antiviral yam kev ua si. Ib qho ntawm feem ntau yam uas muaj cov cuab yeej no - nws imidazoliletanamid pentandiovoy acid.

Nws yog active tawm tsam pathogens hom mob ua npaws A thiab B, adenovirus, parainfluenza thiab pab nrog ua pa syncytial tus kab mob.

Qhov no active compound muaj ib tug tshwj xeeb mechanism ntawm qhov kev txiav txim. Nws cheeb qhov uas cov me nyuam txheej txheem nyob rau hauv cov kab mob tseem theem rau theem thiab kuj qeeb tsiv teb tsaws ntawm tshiab kis neeg sawv cev los ntawm lub cytoplasmic puag ncig Nucleus hlwb.

Tsis tas li ntawd imidazoliletanamid pentandiovoy acid yog kev koom tes nyob rau hauv tus tib neeg lub cev, muab ib tug modulating nyhuv. Cov tshuaj yeeb dej caw tsub kom ntshav interferon cov ntsiab lus mus rau theem ntawm cov physiological cai. nws kuj nkoos hauv tus txheej txheem ntawm α-, γ-interferonproduktsii leukocytes, uas ua rau ib tug coj lub xeev ntawm cov zog.

Kev soj ntsuam ntawm lub active tshuaj pom tias imidazoliletanamid pentandiovoy acid txhawb lub cim ntawm cytotoxic lymphocytes kev txiav txim. Ntxiv mus, nws yuav tsub kom lub xov tooj ntawm NK-T-neeg uas muaj unsurpassed muaj peev xwm ua kom puas hlwb hloov nrog cov kab mob, raws li tau zoo raws li txoj cai ncaj qha rau ntawm pathogens.

Qhov kom zoo dua yog qhov xub ntiag ntawm lub tshuaj muaj anti-inflammatory zog. Lawv yog muab los ntawm suppressing zus tau tej cov cytokines profile, raws li zoo raws li lub txo nyob rau hauv cov kev ua ntawm cov enzyme myeloperoxidase.

kho nyhuv

Imidazoliletanamid pentandiovoy acid, xyuas uas yog zoo, tom ntej no qhia tau hais tias cov kho nyhuv nyob rau hauv cov kev kho mob ntawm SARS thiab kab mob khaub thuas:

• Nws thiaj li ntev ntawm febrile txheej txheem.
• Thiaj li tsos mob ntawm intoxication (kiv taub hau, mob, tsis muaj zog).
• Reduces catarrhal ces.
• Minimizes teeb meem no mob.
• Thiaj li lub sij hawm ntawm kev mob nkeeg.

Tshuaj nrog imidazoliletanamidom pentandiovoy acid

Cov tshuaj yuav muab tau muaj nyob rau nram qab no formulations muaj imidazoliletanamid pentandiovoy acid:

• "Vitaglutam" hmoov.
• "Ingavirin" nyob rau hauv daim ntawv ntawm cov tshuaj.
• "Dicarbamine" tshuaj.

Contraindications

Raws li cov kev siv yeeb tshuaj imidazoliletanamid pentandiovoy acid - ib tug yeeb tshuaj uas yuav tsum tau tswj los ntawm cov kws kho mob. Qhov no kws khoom muaj contraindications, xws li:

• Thaum lub sij hawm uas cev xeeb tub thiab lactation.
• Cov me nyuam mus txog lub hnub nyoog 18 xyoo.
• Npau taws me ntsis ntawm cov tshuaj Cheebtsam.

Sab los ntawm cov tshuaj uas muaj lub piav active tshuaj yuav qhia nyob rau hauv daim ntawv ntawm cov kev tsis haum cov tshuaj tiv thaiv.

Cov nyhuv no yog muab hais tias tus neeg muaj ib tug neeg rhiab heev rau imidazoliletanamidu pentandiovoy acid los yog koom haum pab tshuaj, uas yog ib feem ntawm cov tshuaj.

kev nyab xeeb

Ib txhia neeg sim ua kom tsis txhob siv ntawm cov tshuaj no, ntseeg hais tias imidazoliletanamid pentandiovoy acid - yog ib tug tshuaj tua kab mob. Qhov no saib yog yuam kev, vim qhov no active tshuaj exhibits tsuas antiviral yam kev ua si. Hu ua zoo deprives nws ntawm tag nrho cov kev phiv uas yog xam qhovkev antimicrobial tshuaj profile. Cov tshuaj muaj tsis muaj immunotoxic, carcinogenic, mutagenic los yog haum cev txiav txim tsis muaj irritating lub digestive ib ntsuj av tau yog tsis txo me nyuam muaj nuj nqi twb tsis muaj embryotoxic los yog teratogenic nyhuv.

Cim los ntawm ib tug es siab ua si ntawm cov tshuaj uas yog tsim los ntawm cov imidazoliletanamid pentandiovoy acid analogs uas yog npaum li cas hais lus. Lawv yog sai absorbed nyob rau hauv lub mob huam thiab yog tusyees faib nyob rau hauv nruab nrog cev thiab cov nqaij. Twb tom qab ib nrab ib teev tom qab haus ntawm lub lam muaj nce mus txog nws tshaj plaws nyob rau hauv concentration hauv cov ntshav thiab nyob rau 37 teev. Lub caij ntawm kev kho mob yog 5 hnub. Txhua thawj coj ntawm cov tshuaj ib tug dhia ntawm nws cov ntsiab lus nyob rau hauv cov ntshav, uas txo maj mam thaum lub sij hawm ib hnub. Cov tshuaj nyob rau hauv tib neeg lub cev yog tsis metabolized tso zis unchanged los ntawm ob lub raum thiab cov hnyuv.

feature txais tos

Nws yog ib qho tseem ceeb mus soj ntsuam cov tshuaj regimen ntawm cov tshuaj. Imidazoliletanamid pentandiovoy acid analogs yog yus muaj los ntawm kwv yees li tib yam kev pom zoo rau siv, yuav tsum tau noj ntawm ncauj ib zaug ib hnub twg nyob rau hauv ib tug npaum li ntawm 90 mg tshaj ib lub sij hawm ntawm 5-7 hnub, tsis hais tus noj mov.

Lub peculiarity ntawm no kev kho mob ib tug kws neeg sawv cev yog tias tus loj tshaj efficiency yog tiav thaum muab tom qab tebchaws thawj cov cim qhia ntawm tus kab mob tsis pub dhau thawj ob hnub.

"Vitaglutam" - qhov ntawm cov pab pawg neeg ntawm cov neeg ua hauj antiviral

Lub keeb kwm ntawm cov tshuaj mus rov qab mus rau hauv lub 70s ntawm lub xeem caug xyoo. Nws yog tsim los ntawm tus naas ej Lavxias teb sab kws kho mob pulmonologist Alexander Chuchalin. Lub medicament muaj raws li ib tug lub ntsiab active khoom sib ua zaub mov imidazoliletanamid pentandiovoy acid. "Vitaglutam" twb qhia nyob rau hauv cov lag luam tawm npe "Dicarbamine" kom txog thaum 2008. Nws lub hom phiaj yog hais tias, mus tsim kho hematopoiesis txheej txheem nyob rau hauv cov neeg mob uas tau undergone kev kho kev kho mob ntawm cancer.

Nyob rau hauv 2009, tib neeg yog kev nyuaj siab nrog ib tug txaus ntshai tus kab mob - swine flu, los yog lub A / H1N1. Thaum lub sij hawm no, "Vitaglutama 'txoj kev loj hlob tau zoo heev yam. Aleksandr Chuchalin, uas yog nyob rau ntawm lub sij hawm cov thawj ntawm cov kws kho mob ntawm Lavxias teb sab Federation, txiav txim siab los sim nws creation tiv thaiv cov kab mob swine flu thiab tau tiav kev vam meej tau. Nws hais tias lub domestic khoom, uas yog raws li nyob rau hauv imidazoliletanamid pentandiovoy acid, "Vitaglutam" qhia tau hais tias ib tug ntau dua miv nyuas siv zug tiv thaiv kab mob formidable tshaj lub American kws khoom "Tamiflu". Nws yog kev koom ua ke rau hauv lub kab genome, thiab txav nws.

Lub neej tshiab "Vitaglutam" tshuaj "Ingavirin"

Chuchalin npaj Gennady Onishchenko, cov thawj ntawm cov kab mob tus kws kho mob ntawm Lavxias teb sab Federation, siv nws invention li ib tug zoo cuab tam nyob rau hauv cov kev kho mob ntawm swine flu. Raws li ib tug tshwm sim ntawm kev soj ntsuam tej kev txom nyem ntawm cov tshuaj tau ua, nyob rau hauv uas nws paub tseeb hais tias nws cov hauj lwm zoo nrog hwm rau ntau yam kab mob. Cov tshuaj tau muab ib lub npe tshiab "Ingavirin" thiab tau sau npe nyob rau hauv lub register ntawm cov pab pawg neeg ntawm antiviral thiab immunostimulatory tshuaj.

Thaum cov khoom no yog ib tug kws lub tuam txhab "Valenta" mus rau cov muag khoom, nws twb officially pom zoo los ntawm lub Ministry of Health raws li ib tug kev kho rau cov swine flu thiab tau pib tuav cov ntaub ntawv ntawm muaj koob meej ntawm cov pejxeem. Yog li, peb yuav hais txog lub parallels "Dicarbamine" - imidazoliletanamid pentandiovoy acid - "Vitaglutam", uas yog, nyob rau hauv qhov tseeb, ib tug thiab tib yam tshuaj.

Nws yog ib nqi sau cia qhov tseeb hais tias "Ingavirin" mus rau cov muag khoom nyob rau hauv 2008 ua tsis tag nrho kev soj ntsuam hlw kom qis. Nrog rau cov kev pab Onishchenko nyob rau hauv 2009 ceev raug soj ntsuam rau laboratory nas twb ncaav. Tsis tas li ntawd nyob rau hauv qhov kev tshwm sim, kawm los ntawm hais txog 100 cov neeg mob koom. Raws li cov ntsiab ntawm txoj kev tshawb pab neeg coj mus rau Chuchalin xaus lus hais tias "Ingavirin" tsis pub dhau thawj 48 teev los ntawm thaum pib ntawm kab mob tsom kuj high efficiency kab mob pathogens. Nws txiav txim no yog thaws rov los nyob rau hauv lub yuav txo tau ntawm febrile lub sij hawm, zuj zus lawm toxicity nyob rau hauv laboratory tsiaj thiab cov neeg mob thiab txo catarrhal ces.

Yog li ntawd, muaj yog tsis muaj yog vim li cas yuav tau xav txog imidazoliletanamid pentandiovoy acid uas yog dummy - nws cov hauj lwm zoo yog qhov tseeb clinically.

"Dicarbamine" niaj hnub no

Tam sim no, tag nrho peb cov tshuaj nyob rau hauv lub hauv paus imidazoliletanamida pentandiovoy acid muag nyob ua ib ke thiab yog positioned raws li counterparts rau txhua lwm yam.

"Dicarbamine" pom zoo rau kev siv los ntawm cov neeg mob uas muaj cov phem hlav. Nyob rau hauv tas li ntawd mus rau lub ntsiab active khoom sib ua zaub mov, nws muaj cov mis nyuj qab zib, talc, qos starch, magnesium stearate, colloidal tov ntawm pob zeb ntais dioxide thiab stearic acid.

"Dicarbamine" muaj cov nram qab no kho los:

• Acceleration ntawm Neutrophil ntau yam zoo thiab haumxeeb maturation.
• Gematoprotektsiya nrog myelosuppressive cov kws khomob.
• Txo lub zaus ntawm tshwm sim thiab degree ntawm tshuaj lom neutropenia, leukopenia limiting.

Tej kev npaj no yog pom zoo kom mus thov ntawm kev kawm ntawm cov kws khomob.

Nws cov hauj lwm zoo yog twb khees tom qab txoj Hauj Lwm 21-28 hnub ntawm txhua txhua hnub saib xyuas ntawm cov ntsiav tshuaj.

Ib tug tib koob tshuaj noj tshuaj - 100 mg (1 ntsiav tshuaj) - coj 5 hnub ua ntej pib ntawm cov kws khomob thiab txuas ntxiv thoob plaws hauv cov kev kho mob. "Dicarbamine" muaj cov cuab yeej los mus txhawb nqa thiab prolong lub kev txiav txim ntawm anticancer cytotoxic tshuaj, los txo cov tshuaj lom los ntawm cyclophosphamide thiab platinum raws li cov tshuaj, thiab kuj ua rau ib txwm kev ntawm hematopoiesis.