Fibrates - yog dab tsi? Muaj pes tsawg leeg, siv, contraindications

Nws yog lub npe hu hais tias kab mob plawv yog cov feem ntau ntau pathologies nyob rau hauv lub ntiaj teb no. Zoo txhua txhua neeg laus suffers tawg thiab angina. Coob tug neeg muaj ib tug keeb kwm kev mob kab mob, xws li myocardial infarction thiab cerebrovascular kev huam yuaj. Nws yog tam sim no ib tug pov thawj ncav fact tias cov kab mob plawv yog ncaj qha mus txog rau dyslipidemia. Qhov no raws li txoj cai implies ib tug kev hloov nyob rau hauv cov ntsiab lus ntawm cov roj cholesterol thiab fatty acids nyob rau hauv cov ntshav. Yuav kom normalize lub lipid tshuav nyiaj li cas, cov neeg mob siv statins thiab fibrates. Qhov no pab pawg neeg ntawm cov tshuaj uas yuav tsum tau nyob rau hauv tag nrho cov neeg uas raug pom kom cholesterol nyob rau hauv cov ntshav, tsis hais poj niam txiv neej thiab muaj hnub nyoog.

Fibrates - dab tsi yog nws thiab dab tsi lawv yog siv

Nws yog lub npe hu hais tias cov kev kho mob ntawm atherosclerosis yog tsis tau yam uas tsis muaj kev siv ntawm statins. Lawv cov kws kho rau tag nrho cov neeg uas muaj ib tug ib txwm mus rog, coronary mob plawv, thrombosis. Nyob rau hauv tas li ntawd mus statins, muaj lwm pab pawg neeg ntawm kev npaj - fibrates. Lawv mechanism ntawm qhov kev txiav txim yog me ntsis txawv. Yog li ntawd, cov tshuaj los ntawm tsis muaj txhais tau tias tag nrho cov. Lawv yog cov fibric acid derivatives. Lub ntsiab mechanism ntawm qhov kev txiav txim - tus kho lus ntawm lipid metabolism hauv lub cev. Fibrates - dab tsi yog nws thiab yog dab tsi lawv rau? Los ntawm kev siv ntawm cov kev npaj pom ib tug tseem ceeb yuav txo tau nyob rau hauv cov ntshav triglycerides. Lub ntsiab mechanism ntawm qhov kev txiav txim ntawm fibrates nyob rau hauv lub fact tias lawv qhib lub enzyme - lipoprotein lipase, li no speeding li cov metabolism ntawm cov nqaijrog. Xws li kev cuam tshuam rau lub biochemical dab tshwm sim nyob rau hauv lub cev. Nyob rau hauv tas li ntawd mus rau lub kev kho ntawm dyslipidemia, fibrates muaj lwm yam teebmeem. Cov lawv - lub sib ntaus tawm tsam free radicals, anti-inflammatory thiab tonic cov nyhuv. lawv kuj anticoagulants.

indications fibrates

Vim lub fact tias cov tshuaj muaj ntau yam kev zoo los, lawv muaj ib tug loj ntau ntawm cov ntaub ntawv sau npe. Lub ntsiab hais rau lawv lub hom phiaj yog metabolic syndrome. Qhov no mob yog tsis muaj ib qho kev kab mob, tab sis nws yog ib tug loj predisposing ceeb rau txoj kev loj hlob ntawm cov hlab plawv tus pathologies. Cov kev rau lub metabolic syndrome:

1. Plab rog (duav loj ua los ntawm 90 cm thiab ntau dua).
2. High cholesterol nyob rau hauv cov ntshav mus kuaj.
3. Txo tus nqi ntawm cov kev kub ceev lipoproteins.
4. Kom triglycerides thiab LDL.

Nyob rau hauv Feem ntau, lub metabolic syndrome yog chav uas muaj hom 2 ntshav qab zib, uas tshwm sim nyob rau hauv cov neeg laus. Tej yam zoo predispose rau txoj kev loj hlob ntawm atherosclerosis, piv txwv li tsub zuj zuj ntawm lipids nyob rau hauv lub vascular phab ntsa. Fibrates - dab tsi nws yog ib thiab rau dab tsi lub hom phiaj lawv yog xeem? Nyob rau hauv tas li ntawd mus rau lub metabolic syndrome, indications rau kev siv yog: raws roj ntsha yam ntaub ntawv ntawm dyslipidemia, thiab hypertriglyceridemia. Lawv kuj qhia nyob rau hauv cov neeg mob uas muaj keeb kwm mob ntshav qab zib thiab gout.

Nyob rau hauv dab tsi tej yam kev mob fibrates yog txhob

Txawm tias muaj tseeb hais tias fibrates muaj ib tug xov tooj ntawm zoo piv nrog rau lwm cov tshuaj kom txo tau cov roj (statins), lawv yuav tsum tau siv tsis nyob rau hauv tag nrho cov neeg. Khaws nyob rau hauv lub siab hais tias cov tshuaj muaj feem xyuam rau cov metabolism, ces siv lawv txwv tsis pub nyob rau hauv ib co xeev. Fibrates muaj contraindications rau kev siv ntawm cov nram qab no:

1. Cev xeeb tub thiab pub niam mis.
2. mob siab. Qhov no contraindication vim lub fact tias qhov no pab pawg neeg ntawm cov tshuaj muaj feem xyuam rau cov metabolism hauv fatty acids. Nyob rau hauv daim siab mob npuas paug thiab alcoholic gepatoze ua hauj lwm uas lub cev ho nyom. Vim li no, fibrates tej zaum yuav ua xws cov neeg mob muaj mob loj txim, mus txog rau lub siab tsis ua hauj lwm.
3. Calculous cholecystitis. Ib tug ntawm cov teebmeem ntawm fibrates yog kom ntxiv dag zog lithogenicity, uas yog, tus tsim ntawm gallstones.
4. Mob raum tsis ua hauj lwm. Fibrates kom cov theem ntawm creatinine nyob rau hauv cov ntshav. Yog li ntawd, lawv muaj peev xwm thab mob raum tsis ua hauj lwm.
5. Ceev faj yuav tsum tau tshuaj fibrates mob neeg laus. Lawv siv yog undesirable rau cov neeg kev txom nyem los ntawm tus kab mob alcoholism.

Tshwm sim los ntawm fibrates

Fibrates - dab tsi yog nws thiab yam uas lawv muaj sab los? Nws yuav tsum tau muab sau tseg tias, tsis zoo li lwm yam tshuaj, qhov no pab pawg neeg ntawm cov tshuaj yog heev tsis tshua muaj ua rau ib qho kev tsis haum cov tshuaj tiv thaiv. Lawv muaj peev xwm li ntawd yuav tsum siv nyob rau hauv cov neeg mob uas muaj keeb kwm ua xua, hay fever, thiab hais txog. D. Cuaj kaum, fibrates muaj ib tug xov tooj ntawm lwm yam kev phiv. Cov feem ntau yog xeev siab thiab ntuav, flatulence, mob plab distension. Lawv kuj muaj kev cuam tshuam lub paj hlwb. Nyob rau hauv tej rooj plaub, ua mob taub hau, insomnia thiab kev nyuaj siab. Sab los yog xam tau tias yog thiab hloov nyob rau hauv lub biochemical tsom xam ntawm cov ntshav: nce creatinine, ALT, AST. Nyob rau hauv lub qhaj ntawv ntawm mob raum tus kab mob thiab lub siab yog tsis yog tej rau tus neeg mob lub cev.

Yuav ua li cas cov tshuaj yog fibrates pab pawg neeg?

Rau hnub tim, muaj txog 10 hom ntawm no pab pawg neeg ntawm cov tshuaj. Yuav kom fibrate tshuaj muaj xws li: "Clofibrate", "bezafibrate", "Gemfibrozil" thiab "Fenofibrate". Txhua yam ntawm cov kev npaj txawv raws li tus xov tooj ntawm cov kev phiv thiab ntau npaum lub. Ntsiav tshuaj "Clofibrate" tau paub ntau lub xyoo thiab yog tam sim no tsis tshua muaj siv. Txawm tias ib tug high efficiency, lawv feem ntau ua phiv xws li mob ntawm lub digestive ib ntsuj av tau, mob nyob rau hauv cov nqaij (myositis), muaj siab lithogenic. Nws yog tsawg lom tshuaj "bezafibrate". Nws tsis yog li zoo li thiab sai sai tas los rau ntawm lub cev. Ntsiav tshuaj "Gemfibrozil" tsis pom zoo rau kev siv vim heev heev phiv (tab sis tsawg tshaj li nyob rau hauv daim ntawv thov ntawm medicament "Clofibrate"). Tsis tas li ntawd, vim qhov yuav tsum tau rau long-term siv thiab siab koob tshuaj. Feem ntau cov niaj hnub tus neeg sawv cev ntawm no pab pawg neeg yog cov tshuaj "Fenofibrate". Nws muaj high efficiency thiab yuav luag tsis muaj kev phiv. Tsis tas li ntawd, nws yog tshuaj rau cov neeg mob nrog gout, txij li thaum nws thiaj li cov theem ntawm uric acid.

Fibrates: cov lus qhia rau kev siv ntawm cov tshuaj

Yuav ua li cas feem ntau thiab nyob rau hauv dab tsi noj tshuaj npaum cas rau thov cov tshuaj nyob ntawm seb ntawm kev npaj yog tsa lub mus kawm tus kws kho mob. Ntau zaus tshaj tsis lawv yuav tsum tau noj rau txog ib lub hlis (los yog ntau tshaj) 2-3 ntsiav tshuaj ib hnub twg. Lub ntsiab hais txog - yog metabolic syndrome. Hais tias xws li cov neeg mob feem ntau muab fibrates. Npaj yuav tsum tau ua ke nrog rau txoj kev noj haus thiab ua ntaub ntawv thov nyob rau hauv cov kev tswj ntawm lipid. Ntsiav tshuaj "Gemfibrozil" yog siv 1-2 zaug ib hnub twg 30 feeb ua ntej noj mov rau ib tug ob peb lub hlis. Lawv analogues yog tshuaj "Gevilon" thiab "Normolit". Kev npaj "bezafibrate" muaj nyob rau hauv cov ntsiav tshuaj ntawm 200 mg thiab yog coj 2 lub sij hawm ib hnub twg rau ib lub hli. Tseem tau sau yog ib qho analogue - medicament "Retard" uas muaj 400 mg ntawm active tshuaj. Tshuaj "Fenofibrate" muaj 2 tso tawm cov ntaub ntawv: ntsiav tshuaj thiab nanoparticles. Lawv muab ib tug ntau zoo haum thiab bioavailability thov 1 lub sij hawm ib hnub twg (200 mg) raws li ib tug ob peb lub hlis. Nws analogs - ib tug tshuaj "Traykor" thiab "Lipantil".

Fibrates: tshuaj cov kev sib tshuam

Ua ntej koj yuav pib siv tshuaj nyob rau hauv pab pawg neeg no, koj yuav tsum tham nrog koj tus kws kho mob thiab qhia rau koj li cas lwm yam tshuaj yog siv. Fibrates tsis tau ua ke nrog nephrotoxic thiab hepatotoxic agents. Nyob rau hauv kev, "Cyclosporin" tshuaj. Kev siv cov fibrates yog tsis txaus rau cov neeg mob noj anticoagulant "warfarin". Tsis tas li ntawd, qhov no pab pawg neeg ntawm cov tshuaj yuav tsum tsis txhob ua ke nrog rau lwm cov dipolipidemicheskimi agents (statins). Txij li thaum nws tsub kom qhov yuav tsim myositis.

Xyuas ntawm cov kws kho mob thiab cov neeg mob nyob rau hauv fibrate

Feem ntau cov neeg mob uas siv fibrates es, raws li sau tseg ib tug txo nyob rau hauv LDL roj, triglycerides thiab roj uas txhaws taus. Cov kws kho mob pom zoo kom cov tshuaj rau tag nrho cov neeg mob uas muaj metabolic syndrome vim hais tias ntawm lawv cov qib high efficiency thiab broad-spectrum. Lub tsuas drawback yog ib tug contraindication rau kev siv ntawm fibrates, uas yog feem ntau pom nyob rau hauv cov laus cov neeg mob.