Alanine aminotransferase nce - ib tug kos npe rau ntawm inflammatory thiab degenerative dab nyob rau hauv nruab nrog cev

Vim aminotransferase migrating los ntawm NH2-pawg nrog ib tug γ-amino acid pub rau cov acceptor - α-amino acid tsis muaj tus intermediate tsim ntawm ammonium. Hais tias yog, tus transamination (transamination: reversible hloov lwm lub tsev ntawm cov amino pawg rau keto acid) - ib tug txheej txheem qhib los ntawm nto moo Lavxias teb sab kws tshawb fawb thiab Kritsman Braunstein.

Amino acids (aspartic, glutamic thiab alanine) thaum lub sij hawm transamination hloov dua siab tshiab rau hauv lub sib nug xov α-keto acid, uas yog Cheebtsam ntawm lub tricarboxylic acid voj voog. Thaum lub sij hawm lawv cov oxidation nyob rau hauv lub Krebs voj voog, lawv yog ib qhov chaw ntawm lub zog.

Transamination yog qhov tseem ceeb nyob rau hauv muab lub urea voj voog aspartate.

Txawm tias muaj tseeb hais tias cov transamination tshua yuav tsum tau raug thiab cov uas muaj ntxhiab amino acids: phenylalanine, tyrosine thiab tryptophan - ib tug ua daim ntawv thov nyob rau hauv cov tshuaj tau pom ib tug txhais ntawm cov kev ua ntawm aspartate thiab alanine aminotransferase. Cov enzymes lug faib nyob rau hauv cov ntaub so ntswg ntawm tib neeg lub cev.

Alanine aminotransferase nce nyob rau hauv cov ntshav liab thiab nws cov concentration yog rau lub sij hawm ntau dua piv rau uas nyob rau hauv cov ntshav ntshiab. Qhov siab tshaj plaws concentration ntawm cov enzyme yog tsau nyob rau hauv lub siab nqaij.

Alanine aminotransferase cai yog tsis tau tib yam rau tib neeg lub cev nqaij. Piv txwv li enzyme ua si nyob rau hauv mob cov ntaub so ntswg yog 7.1 (E * 10-3 g cov ntaub so ntswg homogenate), ib tug siab - 44, skeletal nqaij - 4,8, raum - 19, po - 1.2, 0.7, thiab mob ntsws ntshiab - 0,016. Uas twb muaj lawm txoj kev rau qhov kev txiav txim ntawm aminotransferase kev ua si nyob rau hauv cov ntshiab yog muab faib ua ob pawg: cov endpoint (colorimetric, siv pa, tsis txawm peem rau nrog ib tug kub tshuaj cuvette photometric apparatus) thiab kev tig tau (spectrophotometric).

B6 yog ib qho vitamin nyob rau hauv ib tug ntau yam ntawm cov khoom noj. Txawm li cas los, nws yuav tsum tau nco ntsoov hais tias hais tias thaum ua noj ua haus cov txheej txheem (thermal obrobka) lub vitamin puas lawm. Pyridoxine yog ib tug cofactor nyob rau hauv feem ntau enzymes. Concentration pirodoksin-5-phosphate nyob rau hauv cov ntshav tsawg nrog lub hnub nyoog. Yog li ntawd, cov kev ua ntawm no enzyme yog alanine aminotransferase, poob nyob rau hauv cov neeg laus dua 64 xyoo (txog 30%) dua li cov uas muaj hnub nyoog 46-63 xyoo. Lub concentration ntawm vitamin B6 nyob rau hauv cov ntshav ntshiab alanine aminotransferase ua.

Yuav kom txiav txim seb qhov haumxeeb lub xeev ntawm lub siab yog feem ntau kuaj aminotransferase theem nyob rau hauv ib tug neeg mob cov ntshav. Qhov no yog vim feem ntau rau lub fact tias hloov nyob rau hauv lawv cov kev ua no tshwm sim sai npaum li cas tshaj lwm kuaj tsis. Ntaus (tawm) ntawm lub siab enzymes nyob rau hauv cov ntshav yog ib qho hais txog ntawm cytolysis - cell kev puas tsuaj los yog muaj kev cuam tshuam ntawm lawv daim nyias nyias permeability. Thaum Ntsuam xyuas cov kev hloov nyob rau hauv cov kev ua ntawm enzymes tseem ceeb mus nrhiav kom tau qhov chaw ntawm tshem tawm. Koj yuav tsum paub lawv cov kev ua nyob rau hauv cov ntshav thiab lub cev noj qab, lub subcellular localization thiab cov metabolism hauv. Lub enzyme concentration - alanine ntau zog, tshwj xeeb yog nyob rau hauv mob hlwb, yog li ntawd, txawm me ntsis kev puas tsuaj rau lawv provokes ib qho kev nce nyob rau hauv enzyme ua si nyob rau hauv cov ntshav. Muab qhov kev ua si ntawm lub enzyme kuaj cov kab mob ntawm lub siab (tus kab mob siab, steatosis).

Alanine aminotransferase nce necrosis ntawm lub siab, raws li tau zoo raws li parenchymal kab mob siab. Qhov tsawg concentration ntawm cov enzyme yog sau npe nyob rau hauv kab mob siab thiab dystrophy. Nws yuav tsum tau hais tias ib qho kev nce nyob rau hauv aminotransferase kev ua si nyob rau hauv cov ntshiab pib 3-8 hnub ua ntej qhov pib ntawm lub ntsiab kev soj ntsuam tej yam tshwm sim ntawm tus kab mob thiab nce mus txog ib tug tshaj plaws nyob rau hauv thaum ntxov hnub ntawm txoj kev loj hlob ntawm lub pathological txheej txheem.

Yog li, alanine aminotransferase nce: mob npuas paug ntawm lub siab, mob daj ntseg, lub siab ua cancer, heart attack myocardial infarction, muaj lub siab tsis ua hauj lwm, hypoxia, poob siab, myositis, myocarditis, steatosis, pancreatin, mob alcoholism.