Acid phosphatase nyob rau hauv cov ntshav: kev txiav txim, seev suab thiab tus nqi

Acid phosphatase - ib qho enzyme uas accelerates tus decomposition ntawm lwg me me nyob rau hauv lub cev. Kev txiav txim ntawm cov theem nyob rau hauv cov ntshav yog ib qho tseem ceeb rau diagnosing lub noj qab haus huv mob. Muaj ob peb hom acid phosphatases, uas muab ib tug feem tib yam, tiam sis txawv muaj nuj nqis los ntawm txhua lwm yam nyob rau hauv kev sib raug zoo rau lub cev txoj kev ntaub so ntswg, chromosomal keeb kwm, muaj pes tsawg leeg.

tag nrho

Powered enzyme nyob rau hauv acidic tej kev kawm, chaw pib lub npe. Acid phosphatase yog pom nyob rau hauv ntau yam ntaub so ntswg thiab hlwb tej zaum yuav nyob rau hauv lub lysosomes thiab tshaj. Qhov loj tshaj plaws pes tsawg tus txiav txim nyob rau hauv lub prostate caj pas, raws li zoo li nyob rau hauv lub hlwb ntawm cov hauv qab no nrog cev:

• siab;
• po;
• hloov hlwb pob txha;
• ntshav (erythrocytes, platelets, macrophages).

Nyob rau hauv ib tug noj qab nyob zoo kab mob cov kev ua ntawm acid phosphatase yog es tsis tshua muaj. Cov neeg sawv cev ntawm tus txiv neej ib nrab cov theem muaj lub prostatic phosphatase, thiab hais tias uas puas lawm nyob rau hauv daim siab thiab ntshav. Cov enzymes ntawm tus poj niam lub cev tsim tag pov tseg los ntawm lub siab thiab erythrocytes, platelets.

Lysosomal acid phosphatase

Nws nyob rau hauv feem ntau lub hlwb. Nws shortcoming yog ib qho autosomal recessive kab mob, uas yog xam yuav tsum tau lub txiaj ntsim ntawm pathological metabolic dab. Symptomatology ntawm tus kab mob manifests nws tus kheej raws li nram no:

• sib quas ntus xeev siab thiab ntuav;
• tsis muaj zog, tsis ua hauj lwm zoo;
• txos cov ntshav siab;
• nyob rau hauv thaum yau - opisthotonus (qaug dab peg uas tshwm sim ru ntawm lub rov qab arc, cov neeg mob cia siab rau ntawm qhov chaw ntawm lub txaj tsuas caj dab thiab ko taw);
• los ntshav.

Yog hais tias lub enzyme theem yog tsis txaus xwb nyob rau hauv cov ntshav dawb, cov neeg mob feem ntau txom nyem exacerbations mob kab mob.

Prostatic acid phosphatase

Nws yog ib tug marker ntawm cancer dab prostate. Qhov no hom ntawm enzyme yog txiav txim thiab raws li ib tug xeeb leej xeeb ntxwv marker kua nyob rau hauv tej kev txom nyem (rape). Acid phosphatase yog tsa, thiab ib tug ob peb hnub tom qab phais rau cov prostate caj pas los yog me keeb kwm yav dhau.

Optimum pH taw qhia rau cov hauj lwm ntawm lub enzyme - 4.6. Kev ua zoo nkaus li heev dua lwm yam tom qab ib tug txiv neej nce mus txog tiav nkauj tiav nraug.

Tam sim no, kev txiav txim theem ntawm prostatic phosphatase raws li ib tug marker ntawm cancer recedes mus rau hauv lub keeb kwm yav dhau ntawm lub nce paj laum nyob hauv prostate kev antigen, uas yog tau kom paub meej tias hauv lub xub ntiag ntawm tus kab mob ntawm ua ntej lawm theem ntawm kev loj hlob. Cuaj kaum, kev ntsuas ntawm prostatic acid phosphatase yog ib qho tseem ceeb nyob rau hauv kev kwv yees txog rov muaj dua ntawm cancer txheej txheem tom qab phais rau radical prostate tshem tawm.

Qhov tsom xam los mus txiav txim cov hauj lwm zoo ntawm kev kho mob ntawm cov benign prostatic hyperplasia thiab lwm yam prostatic pathologies.

eritrotsitarnaja phosphatase

Qhov no yog ib polymorphic enzyme uas tsis yog tsuas yog nyob rau hauv cov ntshav liab tab sis kuj lwm lub hlwb ntawm lub cev. Lub zoo pH rau nws lub lag luam mas nws txawv ntawm 5.2 rau 6.2.

Acidic phosphatase ntshav yuav tsum tau txiav txim hais tias yog leej txiv. Tej yam ntaub ntawv ntawm qhov enzyme yog txuam nrog rau cov nram qab no tej yam kev mob:

• kev tshuaj ntsuam genetic predisposition mus hemolytic anemia;
• pathology, uas yog tsiag ntawv los ntawm txoj kev loj hlob ntawm hemolytic anemia nyob rau hauv lub keeb kwm yav dhau noj legumes;
• anemia nyob rau hauv qhov kev siv ntawm tej yam tshuaj los yog kev tsim ib tug kab mob ntawm tus kab mob thiab kab mob keeb kwm.

Muaj cov ntaub ntawv ntawm erythrocyte acid phosphatase ncaj qha mus txog rau kev ua txhaum uas tshwm sim nyob rau hauv thaum yau.

Macrophage hom acid phosphatase

Lub enzyme yog ib qho tseem ceeb nyob rau hauv qhov mob ntawm Gaucher kab mob. Qhov no yog ib qho pub tus kab mob uas manifests txuam nyob rau hauv lub siab, tus po, raum, lub hlwb, mob ntsws glucocerebroside (organic tshuaj los ntawm cov pab pawg neeg ntawm cov rog). Tus kab mob yog nrog los ntawm ib tug tseem ceeb nce nyob rau hauv lub loj ntawm lub saum toj no-hais lub cev, ib tug ntse txo nyob rau hauv lub xov tooj ntawm tag nrho cov ntshav, qaug dab peg, spastic qaug dab peg, hlwb ruamqauj.

Macrophage acid phosphatase yog tseem xam tau tias yog ib txog kev marker rau cov ntxhuav cell leukemia. Tus kab mob no yog los ntawm zus tau tej cov tseem ceeb cov nqi ntawm cov enzyme, uas yog txiav txim nyob rau hauv cov ntshav.

phosphatase osteoclasts

Hu osteoclasts pob txha hlwb lub luag hauj lwm rau nws cov kev puas tsuaj. Kauj ruam no yog ib qho tseem ceeb kev saib xyuas ntawm cov pob txha loj hlob thiab kho tsev. High ceev cov pob txha tsis nrog cov nram qab no cov kab mob:

• Paget tus kab mob (pathological synthesis qub pob txha tsim thiab nws cov ntsiab);
• hypercalcemia ntawm malignancy;
• hyperactivity ntawm lub qog thiab parathyroid qog ;
• postmenopause nyob rau hauv ua ke nrog nrog txha.

Tshwm - heev lov thiab hnyav thinning ntawm cov pob txha lug. Kev txiav txim ntawm acid phosphatase osteoclasts qhia tau hais tias kom ntau ntau cov enzymes nyob rau hauv lub keeb kwm yav dhau ntawm lub saum toj no pathologies.

Npaj thiab kev diagnostics

Ntau indicators yog txiav txim nyob rau hauv laboratory tej yam kev mob. Qhov tsom xam yuav tsum tau nqa tawm tom qab 2 hnub ntawm lub sij hawm ntawm lwm diagnostic cov txheej txheem. Yog hais tias koj xav mus ntsuam xyuas cov theem ntawm prostatic acid phosphatase, qhov no yuav tsum tau ua tsis ntxov tshaj li 48 teev tom qab tus me, palpation ntawm lub prostate, zais zis hnab cug zis. Nyob rau hauv lub rov qab cov ntaub ntawv, cov kev tshwm sim tej zaum yuav tsis muaj tseeb positives.

Laj kab cov ntaub ntawv uas cov kev tshawb fawb nqa tawm nyob rau ib qho kev npliag plab. Koj muaj peev xwm haus dej haus dej, haus tshuaj yej, kas fes, kua txiv hmab thiab lwm yam dej yog txwv tsis pub. Thaum lub sij hawm hnub, koj yuav tau muab dej haus cawv, fatty, smoked tais diav, 1 teev ua ntej yuav tsom xam - los ntawm kev haus luam yeeb. Qhov kawg ib nrab teev ua ntej lub kom tsawg ntawm cov khoom yuav tsum tau ua nyob rau hauv tag nrho lub siab lub ntsws tranquility.

Rau cov mob ntawm venous ntshav yog siv, namely nws ntshiab tsis txhob hemolysis. Lub daim ntawv ntsuam xyuas tau no yuav muab lub npe hu ib hnub tom ntej tom qab txoj kev tshawb no.

Cov kev siv

Yuav kom meej lub theem ntawm tag nrho cov acid phosphatase siv immunochemical hom kev kawm nrog chemiluminescent nrhiav kom tau. Siv tshwj xeeb substrates uas nrog tej yam enzymes. Tam sim no systems ntiav luminol derivatives peroxidase nyob rau hauv ua ke nrog nrog hydrogen peroxide tshuaj. Cov nyhuv no yog ntxiv initiator (e.g., n-yodofenol) muaj peev xwm zuj zus lub luminescence ntawm kev daws rau ob peb txhiab lub sij hawm.

Nws muaj lwm yam systems uas siv alkaline phosphatase thiab AMPPD substrate, ua lub diagnostic txoj kev txawm ntau sensitive. Qhov zoo ntawm tus qauv yuav tau kawm cov stability ntawm reagents siv, tsis muaj moj kab mob zoo. Cov kev txwv raws li nyob rau hauv lub complexity ntawm lub diagnostic txheej txheem.

cai

Tag nrho cov acid phosphatase seev qhia U / L. Nws pub tsis sib txawv nyob ntawm seb muaj hnub nyoog thiab yog txivneej los pojniam.

Tej prostatic acid phosphatase indicators - tsawg tshaj li 2.1 ng / ml. Tag nrho cov nuj nqis saum toj no qhia qhov zoo tshwm sim ntawm tus mob.

Thaum lub theem ntawm cov enzyme nce?

Cov loj tshaj plaws tej yam kev mob rau cov uas quantitative ntsuas saum toj no ib txwm:

• thrombocytopenia - ib tug txo tus naj npawb ntawm cov ntshav hlwb lub luag hauj lwm rau nws txhaws;
• thromboembolism - txhaws ntawm lub lumen ntawm lub ntsiab leeg thrombus, tu los ntawm cov hlab lub phab ntsa, los yog embolus, uas yog nyob rau hauv cov hlab ntsha;
• Hemolytic kab mob - ib tug kab mob nrog loj heev kev puas tsuaj ntawm cov ntshav liab rau tso tseem ceeb cov nqi ntawm cov bilirubin nyob rau hauv cov hlab ntsha;
• hnyav Paget tus kab mob - pob txha pathology apparatus uas ib tug tsis txaus ntawm cov pob txha tsim thiab puas tsuaj ntawm Cheebtsam rau hauv dej siab ntawm lub yav tas;
• myeloma - kab mob qog hlav txheej txheem xwm, uas yog kawm los ntawm B-lymphocytes, lub luag hauj lwm rau lub synthesis ntawm kev tiv thaiv lub hlwb;
• Niemann-De kab mob - raws roj ntsha pathology yus impaired roj metabolism thiab txuam nrog ntawm lipids nyob rau hauv lub loj hauv nruab nrog cev (daim siab, po, mob ntsws, plawv, raum);
• ib tug ob peb hnub tom qab phais rau cov prostate caj pas thiab nws cov nqaij mos me.

Acidic, alkaline phosphatase - ib pab pawg neeg ntawm enzymes lub luag hauj lwm rau ib qho tseem ceeb dab nyob rau hauv lub cev. Nws yog nrog lawv pab xeeb tseem ceeb heev sib law liag tshua. Kev txiav txim theem ntawm enzymes tso cai lub sij hawm mus saib cov nyob rau ntawm pathology thiab ua nws los pab txhawb tus kho lus ntawm ntxiv zoo ntawm lub neej.