"Spironolactone": analogues, kev qhia ntawv, kev siv, kev siv yeeb tshuaj piav qhia

"Spironolactone" - yog poov tshuaj thiab magniysberegayuschy diuretic. Cov tshuaj yog ib tug haib diuretic, uas tiv thaiv leaching ntawm lub cev uas tseem ceeb heev ntsev. Nws tseem yuav txo tau qhov acidity ntawm cov zis. Nws yog tsim nyog them sai sai, sim kom hloov cov kev kho mob ntawm "spironolactone". Analogs ntawm cov tshuaj yog tsis ib txwm muaj xws zog.

Qauv thiab pes tsawg leeg

Qhov no tshuaj yog muaj nyob rau hauv cov ntsiav tshuaj daim ntawv. Active tivthaiv yog spironolactone. Nyob rau hauv ib ntsiav tshuaj muaj 25 los yog 100 mg ntawm lub substance. Tsis tas li ntawd, nws yog tsim los ntawm koom haum pab Cheebtsam: qos starch, monohydrate, lactose, povidone, calcium stearate. Ntsiav tshuaj sib npaug tau ntim rau hauv ib lub cardboard lub thawv ntawm 20 daim.

pharmacological los

Tshuaj "spironolactone" yog ib qho aldosterone antagonist. Nws yog ib qho adrenocortical lawm. Aldosterone combining nrog protein receptors distal nephron hlwb thiaj li feem ntawm sodium thiab dej thiab tsub kom poov tshuaj leaching. "Spironolactone" sib tw nrog rau qhov no lawm thiab ua li lawv xav. Cov kev npaj txhawb nqa feem ntawm dej thiab sodium los ntawm lub cev, cov lus poov tshuaj ions. Ntsha tshuav nyiaj li cas yog tsis ntxhov.

Tam sim no txig kawm pharmacodynamics ntawm cov tshuaj. Thaum xav mus nkag rau tus mob huam nws yog absorbed sai sai los ntawm losis tswvyim dabtsi rau ntshav proteins. Bioavailability ntawm cov ntsiav tshuaj yog kwv yees li 99%. Ib tug tua tus kev noj haus accelerates haum ntawm lub active tshuaj active tshuaj.

Tus kho nyhuv, raws li cov kev qhia ntawv no tshwm sim tsis pub dhau 5 hnub. Nws yuav tsum tau nws gradual txuam nyob rau hauv lub cev mus rau ib tug tej concentration mus qhib lub tshuaj. Txwv tsis pub, nyob rau hauv txoj kev xyaum ntawm cov tshuaj nws yog hu ua ib tug loj zus nyhuv. Active tshuaj penetrates sai mus rau hauv niam cov kua mis, thiab muab tau los ntawm lub cev nrog rau cov quav thiab zis. Uas kab mob cov kws kho mob muab cov tshuaj "spironolactone"?

indications

Cov lus qhia rau "spironolactone" qhia tias cov tshuaj yog npaj rau kev kho mob ntawm cov nram qab no cov kab mob thiab pathologies:

• Edematous syndrome uas tshwm sim nyob rau hauv ib tug tom qab ntawm lub plawv tsis ua hauj lwm.
• Hyperaldosteronism.
• Qhov tseem ceeb tawg.
• Secondary hyperaldosteronism tshwm sim los ntawm mob npuas paug.

Rau kev kho mob ntawm ib tug kab mob yuav tsum tau pib tom qab kev sib tham nrog tus kws kho mob.

Contraindications

Nyob rau hauv tej rooj plaub, nws yog tsis pom zoo noj cov tshuaj "spironolactone"? Indications rau siv hais saum toj no tsis yog ib tug ua rau nws tus kheej-kev kho mob. Qhov no tshuaj muaj ntau yam tshwm sim thiab contraindications.

Cov lus qhia rau lub Drug Administration hais tias nws siv rau kho lub hom phiaj yog tsis pom zoo rau cov neeg uas muaj Addison tus kab mob, hypercalcemia, mob ntshav qab zib. Nrog huab ceev faj yuav tsum tau siv cov tshuaj rau cov poj niam nrog cev irregularities, mis o.

Cov lus qhia rau kev siv

Qhov no medicament yog haum rau qhov ncauj thawj coj. Cov koob tshuaj yog txiav txim los ntawm tus kws kho mob rau ib tug neeg hauv paus, raws li nyob rau hauv lub heev ntawm kev ua txhaum ntawm cov dej-ntsha tshuav nyiaj li cas thiab hormonal ntau ntawm tus neeg mob.

Thaum edema tshwm sim los neurotic syndrome, txoj kev kho yog pib nrog 100-200 mg ntawm cov tshuaj ib hnub twg. Cov tshuaj yuav tsum tau muab faib ua ob los yog peb koob tshuaj. Lub caij ntawm kev kho mob yog hais txog peb lub lis piam. Nyob rau hauv cov ntaub ntawv ntawm hyperaldosteronism thiab tsawg poov tshuaj ntshav medicament "spironolactone-Darnitsya" yog muab rau 300 mg ib hnub twg.

Thaum ib tug hydropic syndrome, uas txuam nrog tus mob xwm ntawm mob insufficiency, kev kho mob yog 5 hnub. Cov ntsiav tshuaj muab nyob rau hauv ib tug ntau npaum ntawm 100-200 mg. Tsis tas li ntawd, cov neeg mob feem ntau yog tshuaj thiazide thiab voj diuretics. Thaum lub zoo zog ntawm rov qab ntau npaum yog maj poob mus rau 25 mg ib hnub twg.

phiv

Yuav ua li cas yog cov kev phiv tau "spironolactone"? Analogs ntawm cov tshuaj no muaj cov neeg pluag tsiv. "Spironolactone", rau hauv sib piv, yus muaj los ntawm ceev ceev haum thiab zoo kho nyhuv. Qee zaus thiaj paub hais tias muaj kev phiv, uas nyob rau hauv lub txhab daim ntawv hauv qab no.

1. Metabolism hauv: kev hloov nyob rau hauv lub acid-puag tshuav nyiaj li cas, hyperuricemia.
2. Cns: nce nkees nkees, mob taub hau, nkees.
3. Circulatory system: megaloblastoz, thrombocytopenia.
4. GI: mob plab, mob rau sab hauv, plab hnyuv tu-sauv, raws plab.
5. Endocrine system: erectile kawg, mis carcinoma, brutalization pov ntawv tawm suab.
6. Cov kev tsis haum: khaus, tawm pob, ua xua.

Yog hais tias koj muaj kev tsos mob yuav tsum sab laj nrog ib tug kws kho mob raws li tau piav saum toj no. Raws li ib tug txoj cai, tus kws khomob tshwjxeeb txiav txim siab los hloov "spironolactone". Analogs ntawm cov tshuaj no kuj muaj kev phiv, tab sis lawv yog qhia rau ib tus twg lesser.

ceev faj

Thaum lub sij hawm kev kho mob "spironolactone":

• Nws yog pom zoo kom tsis txhob noj cov khoom noj uas nplua nuj nyob rau hauv poov tshuaj.
• Nruj me ntsis txwv tsis pub muaj tag nrho cov dej cawv haus.
• Nws yuav tsum caiv los ntawm cov simultaneous daim ntawv thov ntawm medicaments nyob rau hauv muaj pes tsawg leeg uas potassium yog tam sim no.

Yog hais tias cov kev kho mob yog ntxiv muab narcotics yuav muab, nws yog tsim nyog los saib xyuas cov hauj lwm ntawm ob lub raum thiab ntsuas ntawm electrolytes nyob rau hauv cov ntshav.

Nyob rau hauv thawj zaug rau theem ntawm txoj kev kho nws yog pom zoo kom txhob tsav tsheb tsheb thiab ua hauj lwm nrog loj mechanisms uas yuav tsum tau ib tug muaj feem psychomotor tshua thiab xim. Lub caij ntawm xws txwv yog teem ib lub zuj zus, raws li nyob rau hauv tolerability, "Spironolactone".

Tus nqi ntawm cov tshuaj thiab cia tej yam kev mob

Tus nqi ntawm cov tshuaj mas nws txawv los ntawm nws cov tshuaj. Rau ib tug ntim ntawm cov ntsiav tshuaj yuav tsum tau them los ntawm 30 mus rau 50 rubles. Cov tag nrho cov nqi kuj yog nyob ntawm lub ntug, uas yog teem ntau lub chaw muag tshuaj chains.

Raws li cov lus qhia, cov kev npaj yuav muab cia rau hauv ib tug kub tsis siab tshaj 20 degrees, tawm ntawm ncav cuag ntawm cov me nyuam ob txhais tes qhov chaw. Txee lub neej yog 3 lub xyoo.

tshuaj analogues

Yuav ua li cas cov tshuaj yuav tsum tau hloov los ntawm "spironolactone"? Analogs ntawm lub medicament nyob rau hauv feem ntau muaj zoo xws li cov muaj pes tsawg leeg thiab concentration ntawm lub ntsiab tivthaiv. Cov no muaj xws li nram qab no tshuaj: "Veroshpilakton", "aldactone", "Veroshpiron". Cov yav tas yog feem ntau siv nyob rau hauv qhov chaw ntawm lub qhia nyob rau hauv no tsab xov xwm cov tshuaj.

Ntawm cov zoo-paub generic tshuaj muaj xws li cov nram qab no: "Dekriz", "Inspra", "Espirit", "Epletor". Mechanism kev txiav txim ntawm lawv yog zoo li "spironolactone". Indications thiab bioavailability ntawm tib. Cov diuretics yog zoo heev rau lub normalization ntawm cov ntshav siab, ntsoos ntsoos ntawm tshaj kua los ntawm lub cev. Txawm li cas los, generic suab tsis tiv thaiv leaching ntawm poov tshuaj thiab magnesium, txawm li cas los, muaj ntau yam cov kws kho mob xav kom siv tus thawj yeeb tshuaj.

Yuav kom saib lub ntsab lug

Tam sim no uas koj paub nyob rau hauv dab tsi pathologies thiab mob taw "spironolactone". Tus nqi ntawm cov tshuaj thiab nws thoob plaws muaj - ob lub ntsiab kev los ntawm cov uas muaj ntau cov neeg mob xav li no medicament. Heev heev zoo xyuas kuj ua pov thawj zoo heev "spironolactone".