"Passazhiks": cov lus qhia rau kev siv. "Passazhiks": indications rau siv, tiag tiag counterparts

Ntuav reflex hu ua qhov uas ntawm lub qhov ncauj (tej zaum los ntawm lub qhov ntswg), tus txheem ntawm lub plab los sis duodenum 12. Qhov no tshwm sim yog vim ib tug yuav txo tau xovxwm leeg.

Thaum lub sij hawm ntuav cov qhov tso zis feem ntawm lub plab kaw thiab nws lub cev yog kiag li so. Nyob rau hauv no nkag yog qhib, thiab expanding cov hlab pas thiab lub qhov ncauj kab noj hniav.

Tag nrho piav txog tus reflex ua yog tswj los ntawm cov ntuav chaw, uas yog nyob rau hauv lub medulla oblongata. Lub xeev no ntawm tus txiv neej yuav pom nyob rau hauv kis kab mob, raug tshuaj lom, txuam nrog ntawm toxins nyob rau hauv cov ntshav, uas muaj peritoneal voos, ulcers, gastritis, cev xeeb tub cov poj niam thiab lwm tus neeg.

Episodic ntuav yog tsis nrog los ntshav, thiab tsis hem tus neeg mob lub neej. Tab sis, yog hais tias tus txheej txheem no yog rov qab rau thiab feem ntau, nws yuav ua tau kom loj txim. Cov no muaj xws lub cev qhuav dej thiab mob electrolyte tsis txaus uas yuav ua tau kom tuag. Uas yog vim li cas nws yog ib qho tseem ceeb mus ntsib ib tug kws kho mob thaum ib tug periodic ntuav. Tsis tas li ntawd yuav tsum tau coj hom tshuaj tshwj xeeb, uas yuav pab tau suppress lub reflex.

Cov feem nrov antiemetics xws li cov tshuaj raws li "Passazhiks". Indications rau kev siv ntawm cov tshuaj, thiab cov lus qhia yuav hais hauv qab no.

Tso daim ntawv no, muaj pes tsawg leeg thiab packing

Nyob rau hauv dab tsi daim ntawv no yog muaj tshuaj "Passazhiks"? Consumer xyuas qhia tias cov tshuaj yog muag nyob rau hauv daim ntawv ntawm cov chewable ntsiav tshuaj. Lawv tau ntim rau hauv cov hlwv thiab cov duab los qhia lub thawv, ntsig txog.

Lub active ingredient xam tau tias yog tshuaj ua domperidone. Raws li koom haum pab tshuaj siv los yog aspartame, xylitol, lactitol, magnesium stearate thiab pum hub qhuav.

pharmacological yam ntxwv

Cov lus qhia rau kev siv ( "Passazhiks" yuav tsum tau tsuas yog siv los ntawm cov tshuaj) qhia tias tus neeg saib xyuas yog suav tias yog ib tug anti-emetic tshuaj. Nws yog ib qho antagonist ntawm central dopamine receptors.

Active medicament muaj peev xwm sawv zuj zus lub caij ntawm peristaltic lus nyob rau hauv lub antrum ntawm lub plab thiab duodenum 12. Nws kuj accelerates tus muab nchuav ntawm tus txheem ntawm lub digestive ib ntsuj av tau (thaum lub sij hawm deceleration ntawm tus txheej txheem), eliminates xeev siab thiab ntuav, tsub kom lub suab nrov ntawm lub esophageal sphincter (sab seem).

Peb kuj yuav tsum nco ntsoov tias domperidone es tsis zoo penetrates rau hauv lub ntshav-hlwb barrier. Uas yog vim li cas txoj kev siv cov tshuaj no tsis tshua muaj nrog nws lus los extrapyramidal tshua.

Nws yuav tsum tau muab sau tseg tias domperidone yog tau mus tsim kho prolactin tso tawm los ntawm lub pituitary.

Action (antiemetic) ntawm cov tshuaj no vim qhov tus ntawm ib tug ua ke ntawm gastrokinetic thiab dopamine thaiv nyob rau hauv lub chemoreceptor txhais tsam. Nws yuav tsum raug hais tias lub tshuaj muaj tsis muaj kev phiv ntxim rau cov pais plab tso pa tawm.

kev tig tau zog

Yuav ua li cas yog lub xam qhovkev kev tig tau tsis medicament "Passazhiks"? Cov lus qhia rau kev siv ntawd hais tias tom qab noj cov chewable ntsiav tshuaj, cov active ingredient nws yog heev sai absorbed rau hauv cov hlab ntsha.

Domperidone muaj tsawg bioavailability (kwv yees li 15%). Nws siab tshaj plaws concentration yog cai tom qab 65 feeb.

Txo pais plab acidity tej zaum yuav txo cov tshuaj haum.

Raws li kws txawj, domperidone yog dav faib nyob rau hauv ntau yam ntaub so ntswg. Raws li rau lub paj hlwb, lub concentration ntawm cov tshuaj nyob rau hauv nws yog me me. Kev sib txuas lus nrog ntshav cov nqaijrog yog hais txog 92-93%.

Tsis tas li ntawd nco ntsoov tias cov tshuaj "Passazhiks" (ntsiav tshuaj) yog metabolized nyob rau hauv daim siab thiab lub plab phab ntsa. Tso zis rau nws ntawm txoj hnyuv (txog 66%) thiab ob lub raum (kwv yees li 33%).

Lub ib nrab neej ntawm cov tshuaj yog 7-8 teev. Rau hauv loj heev raum tsis ua hauj lwm muab luv yog lengthened.

zaj lus tim khawv

Saib medicament kws kho rau xeev siab thiab ntuav ntawm ntau yam keeb kwm, nrog rau cov organic thiab haumxeeb cov kab mob, tawg txoj kev kho thiab kab mob. Tsis tas li ntawd, qhov cuab tam yuav raug nyob rau hauv lub toxemia, noj morphine, noj cov zaub mov ua txhaum, kev siv ntawm "Levodopa", "Apomorphine" thiab "Bromocriptine".

Nyob rau hauv dab tsi lwm yam mob, tshuaj tej zaum yuav siv "Passazhiks"? Cov lus qhia rau kev siv qhia hais tias qhov no tshuaj yog feem ntau tus kws kho thaum lub sij hawm atony ntawm tus mob huam (xws li postoperative), nros, radiopaque thiab endoscopic digestive ib ntsuj av tau cov kev tshawb fawb. Tsis tas li ntawd xam tau tias yog tshuaj yuav tsum tau mus leeb peristalsis nyob rau hauv diagnostic cov txheej txheem, dyspeptic mob tshwm sim raws li ib tug tshwm sim ntawm ncua pais plab muab nchuav, esophagitis, thiab Gastroesophageal reflux.

Ntsiav tshuaj "Passazhiks", indications uas yuav sib tham txog saum toj no yog cov zoo manifest nws tus kheej nyob rau hauv ib tug kev xav ntawm fullness nyob rau hauv lub plab, flatulence, tsam plab nov ntawm nqaij tawv, gastralgia, kub siab thiab belching.

Contraindications

Thaum koj yuav tsum tsis txhob siv cov ntsiav tshuaj "Passazhiks"? Cov lus qhia rau kev siv, xyuas tau qhia cov nram qab no contraindications ntawm cov tshuaj nyob rau hauv kev saib xyuas:

• npau taws me ntsis;
• Cov me nyuam nyob rau hauv lub hnub nyoog ntawm 5 xyoos, raws li tau zoo raws li cov me nyuam mos uas mus txog 20 kg;
• prolactinoma;
• fenilketonuriyaiya.

Nws yuav tsum tau muab sau tseg tias lub cuab tam yog tsis qhia yog hais tias tus lub cev muaj zog stimulation ntawm lub plab yuav ua tau txaus ntshai (rau hnyuv los ntshav, perforation, los yog txhua yam dab tsi thaiv).

Yuav ceev faj ntawm no yeeb tshuaj muaj peev xwm yuav siv tau nyob rau hauv cov neeg mob uas raum los yog hepatic insufficiency thaum lub sij hawm cev xeeb tub thiab lactation.

Ntsiav tshuaj "Passazhiks": cov lus qhia rau kev siv

Chewable ntsiav tshuaj "Passazhiks" pom zoo kom noj ¼ teev ua ntej noj mov.

Nyob rau hauv ntev dyspepsia neeg laus taw 10 mg tshuaj (1 ntsiav tshuaj) peb zaug ib hnub twg. Yog hais tias tsim nyog, noj tshuaj yuav tsum noj thaum caij pw.

Cov me nyuam laus tshaj 5 xyoo, qhov no twj muab 2.5 mg ib 10 kg ntawm lub cev hnyav ib hnub peb zaug thiab, yog tias tsim nyog, ua ntej yuav mus pw.

Nyob rau hauv subacute los yog mob lub xeev (xeev siab thiab ntuav) los siv rau cov neeg laus cov neeg mob ntawm 20 mg plaub zaug ib hnub twg, thiab ua ntej yuav mus pw. Cov me nyuam laus tshaj 5 xyoo yog pom zoo kom noj 5 mg ntawm cov tshuaj ib 10 kg ntawm lub cev hnyav plaub zaug ib hnub twg thiab thaum mus pw.

Nyob rau hauv lub raum tsis ua hauj lwm yuav tsum tau ntau npaum hloov multiplicity tau txais tsis muaj ntau tshaj li 1-2 lub sij hawm thaum lub sij hawm ib hnub.

Qhov siab tshaj plaws ntau npaum cov tshuaj ib hnub twg rau cov neeg laus yog 80 mg (ie 8 ntsiav tshuaj). Nrog kev xav txog cov me nyuam, nws yuav tsum tsis txhob muaj ntau tshaj li 10 mg rau ib 10 kg nyhav rau tus me nyuam.

phiv

seb phiv tshua chewable ntsiav tshuaj "Passazhiks" ua? Guest kws txawj hais tias qhov no lub cuab tam yuav ua phiv los nyob rau hauv daim ntawv ntawm:

• nraum plab hnyuv tu-sauv;
• extrapyramidal los;
• kom prolactin concentration nyob rau hauv cov ntshav;
• galactorrhea, gynecomastia thiab dysmenorrhea;
• pob, thiab urticaria.

Cov tsos mob ntawm overdose

Yuav ua li cas yog cov tsos mob ntawm overdose yuav ua rau cov tshuaj "Passazhiks"? Phau ntawv lub xeev hais tias xws li phenomena xws li nkees nkees, tsis meej pem thiab extrapyramidal tshua.

nws yog pom zoo kom noj tshuab txais hluav ncaig thiab sab laj ib tug kws kho mob rau kev kho mob ntawm xws tej yam kev mob.

Sis nrog lwm yam tshuaj

Tib mus kho mob tshuaj "Passazhiks" nrog anticholinergics yuav neutralize cov nyhuv uas cov thawj.

Ua ke nrog nrog antacids thiaj li nws bioavailability.

Thaum ua ke thiab domperidone medicaments inhibiting lub isozyme CYP3A4 (e.g., tshuaj tua kab mob macrolides, azole antifungals pab pawg neeg, ib tug antidepressant "Nefazodone" HIV protease inhibitors), tus neeg mob tej zaum yuav muaj ib qho kev nce nyob rau hauv concentration ntawm lub active tshuaj nyob rau hauv cov ntshav.

Saib cov tshuaj tsis cuam tshuam rau concentration ntawm digoxin nyob rau hauv ntshav thiab paracetamol. Nws yog tsis cais tias nws yuav cuam tshuam rau haum cov tshuaj (ib txhij thov hais) nrog ncua kev tso tawm ntawm active ingredient los yog enteric-coated.

Kev pub niam mis thiab cev xeeb tub

Tshuaj "Passazhiks" txwv tsis pub nqa mus siv rau thaum lub sij hawm cev xeeb tub.

Thaum lub fairer nrog txiv neej pw domperidone concentration hauv cov mis nyuj yog plaub lub sij hawm tsawg dua nyob rau hauv ntshav. Nws yog tsis paub hais tias seb qhov no muaj ib tug tsis zoo feem nyob rau cov me nyuam. Yog li ntawd, yog tias tsim nyog, siv cov tshuaj thaum lub sij hawm lactation pub niam mis yuav tsum tau txiav.

Ntsiav tshuaj "Passazhiks": counterparts thiab nqi

Tus nqi ntawm cov nyiaj yog hais txog 220-360 rubles. Yog hais tias qhov kev kawm, tus antiemetic tshuaj yuav hloov los ntawm ib tug ntawm xws tshuaj raws li "Motilium", "Domstal", "Kinedril", "Avioplant", "Doprokin-C", "Diskineton", "Emeset", "Motinol" thiab thiaj li. d.

Nws yuav tsum tau recalled hais tias tag nrho cov ntawm cov nyiaj no yuav muaj lawv tus kheej cov yam ntxwv. Yog li ntawd, yuav siv lawv es tsis txhob "Passazhiksa" yuav tsum tsuas yog tom qab kev sib tham nrog tus kws kho mob.

Xyuas ntawm kev npaj

Feem ntau ntawm cov neeg mob kho nrog cov tshuaj nyob rau hauv lo lus nug, sib tham txog nws cov high efficiency. Raws li rau cov neeg siv, qhov no txhais tau tias zoo nkauj sai sai tshem tawm cov kev xav ntawm xeev siab thiab pub ntuav.

Nws yuav tsum tau muab sau tseg tias cov tshuaj no yuav tsum noj nrog rau lwm cov tsos mob. Piv txwv li, nws yog feem ntau siv rau ib tug luj nyob rau hauv lub plab los sis mob plab distention. Nyob rau hauv cov ntaub ntawv no, lub ntsiav tshuaj chewable kom noj ib lub nyob hauv ib lub sij hawm peb lub sij hawm ib hnub twg rau tsib hnub.

Lub ntsiab drawbacks ntawm cov kev npaj "Passazhiks" yog hais txog sab los sawv tawm tsam nws txais tos, raws li zoo raws li lub xub ntiag ntawm txawv contraindications.