Cov tshuaj "Topamax": cov lus teb ntawm cov neeg mob thiab cov kws kho mob

Yog tias xws li ib tug yeeb tshuaj, raws li "Topamax"? Xyuas ntawm cov kws kho mob thiab cov neeg mob yuav tsum tau hais hauv qab no. Tsis tas li ntawd, koj yuav kawm tau los ntawm dab tsi yog muab rau cov tshuaj no yuav tsum tau siv thiab cov uas kho thaj chaw nws yog yus.

Muaj pes tsawg leeg, zoo

Nyob rau hauv dab tsi daim ntawv muag cov tshuaj "Topamax"? Testimonials qhia hais tias qhov no lub cuab tam yuav tsum yuav nyob rau hauv daim ntawv ntawm gelatin tsiav tshuaj, khoom dawb.

Lub active ingredient ntawm cov tshuaj yog topiramate. Tsis tas li ntawd nyob rau hauv nws muaj pes tsawg leeg muaj xws li cov nram qab no pab hais: qab zib grits, povidone, thiab cellulose acetate.

Cov muag yeeb tshuaj "Topamax" (xyuas ntawm cov kws kho mob hais txog nws yog heev tsis meej xwm ua cim) los rau hauv hnab yas fwj thiab packs ntawm cov duab los qhia ntsig txog.

Cov yam ntxwv ntawm cov tshuaj

Yuav ua li cas yog tsiav tshuaj "Topamax"? Xyuas tau qhia hais tias qhov no antiepileptic yeeb tshuaj, uas koom rau fructose. Nws khiav hauj lwm lub caij tau inhibit sodium raws, tab sis kuj qeeb tus mob ntawm repetitive txiav txim potentials nyob rau hauv heev depolarization ntawm lub neuron phab ntsa.

Txais tos qhia txhais tau tias tsub kom cov kev ua ntawm γ-aminobutyric acid nyob rau hauv kev sib hwm ntawm cov hom ntawm GABA-receptors. Tsis tas li ntawd, active tshuaj uas muaj peev xwm ntawm thaiv cov hlab ua kom cov kainate rau glutamate receptors, thiab tswj cov kev ua ntawm GABA-receptors. Tej tshuaj los yog tshuaj txog cov tshuaj thiab pom rau nws tseem ceeb nyob rau hauv cov ntshav 1-205 micromolar.

Yuav ua li cas lwm yam khoom yog cov yam ntxwv ntawm cov tshuaj "Topamax"? Xyuas lub xeev uas nws cov ntsiab muaj yog tau inhibit qhov kev ua si ntawm carbonic anhydrase tooj ntawm isomers. Nws yuav tsum tau muab sau tseg tias heev ntawm lub pharmacological thaj chaw ntawm cov tshuaj yog heev ua tsis tau zoo rau carbonic anhydrase inhibitors, piv txwv li acetazolamide. Tej yam kev ua si ntawm cov tshuaj tsis yog ib tug loj feem ntawm nws antiepileptic kev txiav txim.

Kev tig tau cov yam ntxwv ntawm cov kev npaj

Seb tshuaj yog absorbed "Topamax"? Xyuas hais tias tom qab noj cov active tshuaj nws txhais tau hais tias sai heev absorbed los ntawm cov hnyuv. Yog li lub bioavailability ntawm topiramate nce mus txog 81%. Noj cov zaub mov twb tsis muaj ntxim rau qhov ntsuas no.

Thwj toob ntawm tus active tshuaj tivthaiv rau ntshav cov nqaijrog nce mus txog 13-16%.

Mus cuag equilibrium rau cov neeg uas ib txwm raum muaj nuj nqi yuav tsum tau hais txog 4-8 hnub. Transformation undergoes txog 20% ntawm cov tshuaj tau txais cov nyiaj. Qhov no ntaub ntawv rau metabolites (tsaug).

Topiramate, raws li zoo raws li tag nrho cov derivatives ntawd, muab tau los ntawm ob lub raum. Lub sij hawm lawv ib nrab-lub neej yog 22 teev.

Indications tau txais lam tsiav tshuaj

Nyob rau hauv tej rooj plaub, cov neeg mob cov kws kho ib yam tshuaj "Topamax"? Xyuas ntawm migraine yog tsuas zoo. Saib npaj siv tsis tau tsuas yog rau cov kev kho mob ntawm hais tias neurological kab mob, tab sis kuj rau nws tiv thaiv.

Nws yuav tsum raug sau tseg hais tias qhov no cuab tam yog zoo manifested nws tus kheej nyob rau hauv qaug dab peg. Nws yog siv rau monotherapy ntawm cov me nyuam los ntawm ob xyoos thiab cov neeg laus. Nyob rau hauv tas li ntawd, "Topamax" yog feem ntau pom zoo kom coj cov neeg uas muaj tshiab khiv paub hais tias qaug dab peg.

Raws li ib feem ntawm lub complex txoj kev kho ntawm cov tshuaj no yog qhia rau cov me nyuam los ntawm ob xyoos thiab laus cov neeg mob uas ib feem los sis tonic-clonic generalized qaug dab peg, raws li zoo raws li rau kev kho mob ntawm Lennox-Gastaut syndrome.

Contraindications kom tau txais kev lam tsiav tshuaj

Nyob rau hauv tej rooj plaub, koj muaj peev xwm tsis tau lub tsiav tshuaj "Topamax"? Xyuas (cov me nyuam nyob rau hauv ob lub xyoos ntawm cov tshuaj no yog txhob) hais tias saib cov tshuaj tsis tau siv nyob rau hauv cov neeg mob hypersensitive rau nws lub Cheebtsam.

Nrog huab ceev faj yuav tsum raug siv yam tshuaj no nrog lub siab ua hauj lwm, nefrourolitiaze, raum tsis ua hauj lwm thiab hypercalciuria.

dosing

Txais tshuaj "Topamax" yuav tsum tau muab hais. Lub tsiav tshuaj yuav raug nqos tag nrho, thiab nws tseem tau los mus sib tov lub txheem nrog ib tug me me npaum li cas ntawm cov mos mos cov khoom noj.

Rau tus tswj ntawm epileptic qaug dab peg txoj kev kho pom zoo kom pib nrog ib tug tsawg txais tos medicament koob, thiab ces titrated li lawv npaum.

Thaum tonic-clonic qaug dab peg thiab cov syndrome Lennox-Gastaut yam tsawg kawg nkaus zoo koob tshuaj ntawm cov tshuaj yog 200 mg ib hnub twg. Nyob rau hauv tej rooj plaub, cov neeg mob uas tau txais nyiaj pab ntau tshaj txhua hnub koob tshuaj yuav tsum tau qhia sib npaug zos rau 1600 mg.

Nyob rau hauv cov me nyuam ob xyoos ntawm cov pom zoo txhua hnub koob tshuaj yog 5-9 mg ib kg ntawm lub cev hnyav.

Yuav ua li cas mus kho cov tshuaj yuav tsum tau noj nrog qaug dab peg? Monotherapy neeg laus kho 25 mg ib zaug ib hnub twg rau ib lub lim tiam. Ntxiv mus, qhov no tus xov tooj yog nce los ntawm 25-50 mg txhua txhua 1-2 lub lis piam.

Cov pom zoo ntau npaum rau monotherapy ntawm qaug dab peg nyob rau hauv cov me nyuam yaus muaj peev xwm sib txawv nyob rau hauv ntau 100-400 mg ib hnub twg.

Rau kev tiv thaiv ntawm migraine tshuaj no yuav tsum siv sij hawm 50 mg ib hnub ob zaug. Yog hais tias tsim nyog, lub koob tshuaj yuav tau nce (mus txog qhov pib ntawm kev soj ntsuam cov nyhuv).

sab-los ntawm cov ua cim

Saib yeeb tshuaj muaj peev xwm ua tau ntau yam ntawm sab kev tshua. Feem ntau cov feem ntau manifested yog raws li nram no:

• nkees nkees, tsis muaj zog, kiv taub hau, tshee, apathy, apraxia, txawv txav xav, amnesia, impaired kev sib koom tes, dystonia;
• tsis meej pem, kev quaj, qeeb xav, hallucinations, kev nyuaj siab, poob libido, euphoric mus ob peb vas, txhoj puab heev tshua;
• anorexia, pancreatitis, gastritis, flatulence, dyspeptic cov tsos mob;
• chua, tu-sauv, o ntawm lub pob qij txha;
• unilateral dig muag, presbyopia, conjunctival edema, thiab lwm tus neeg.

Medicament "Topamax": xyuas

Qaug dab peg - ib tug thawj kab mob nyob rau hauv uas cov tshuaj yog muab kev saib xyuas. Raws li cov nqe lus ntawm cov kws kho mob nrog rau cov mob no noj tshuaj tsis yog ib txwm qhia txaus kho miv nyuas siv zug. Nyob rau hauv tas li ntawd, nws txhawb nqa lub plurality ntawm txais tos sab tshua, xws li rau ib feem ntawm lub paj hlwb thiab psyche.

Raws li rau cov neeg mob, lawv kuj tau taw tes rau cov neeg pluag tolerability ntawm cov tshuaj. Uas yog vim li cas muaj ntau yam ntawm lawv xav kom siv cov kev ruaj ntseg cov nyiaj lawv tus kws kho mob hais.

Peb tsis tau hais tias cov tshuaj nyob rau hauv lo lus nug yog dav siv los ntawm ntau cov neeg mob raws li ib tug txhais tau tias kom poob ceeb thawj. Txawm li cas los, cov kws txawj qhia tias thaum noj tsiav tshuaj "Topamax" rau cov hom phiaj yuav tsum tau muab los xav nws cov high toxicity.