Cov tshuaj "Celebrex": xyuas, analogs, cov lus qhia rau kev siv, nqe

Lub yeej ntawm cov nqaj qaum, mob heev nyob rau hauv cov pob qij txha thiab connective cov ntaub so ntswg hloov zog nyob rau tom qab ntawm o - hmoov tsis, cov kabmob no muaj feem ntau nyob rau hauv peb lub sij hawm. Nyob rau lub xeev no ntawm tej xwm txheej muaj feem xyuam rau txoj kev ua neej, tsis muaj dab tsi lub cev ua si, kev tshuaj ntsuam genetic yam. Nyob rau hauv tas li ntawd mus rau mob hnyav mob uas neeg raug kev txom nyem nyob rau hauv tus mob no, mob nkees uas muaj peev xwm ntawm kev rhuav tseg tag nrho cov kab mob, Process ntshav Science News for KIDS thiab rau lub cev tau hauj lwm ntawm sab hauv nruab nrog cev.

Nws yog yog li ntawd ib qho tseem ceeb los mus saib xyuas cov kev kho mob thiab lub sij hawm los kho tus kab mob no. Ib tug ntawm qhov zoo tshaj tshuaj, uas belongs rau cov pab pawg neeg uas tsis yog-tshuaj tshuaj hu ua medicament "Celebrex". Xyuas ntawm cov kws kho mob paub meej tias nws cov hauj lwm zoo nyob rau hauv kev sib piv nrog rau tib yam kab ntawm anti-inflammatory siv tshuaj.

Lub ntsiab nyhuv ntawm cov tshuaj

Ib tug kom zoo dua ntawm cov tshuaj yuav tsum tau muab hu ua nws muaj peev xwm inhibit qhov kev inflammatory txheej txheem kev ua si sib txawv theem ntawm tus kab mob. Ib zaug nyob rau cov ntshav, cov tshuaj yog tau inhibit TSOG2 txheej txheem uas ua rau yus nyem mob. "Celebrex" Cov tshuaj muaj ib tug muaj zog analgesic vaj tse antipyretic kev ua si. Yog li ntawd, nws tsis tsuas eliminates lub o foci, tab sis kuj zoo kawg nkaus tshem tawm txawm mob heev, thiaj li kub ib ce.

Qhov zoo ntawm cov khoom no muaj xws li nws tsawg heev ntxim rau cov platelets, uas yog, cov tshuaj tsis ua teeb meem nrog cov ntshav txhaws. Thaum koj tau txais ib tug uas tsis yog-tshuaj neeg sawv cev uas muaj yog tsis muaj voos ntawm lub plab thiab cov hnyuv, txo txoj kev pheej hmoo ntawm ulcers thiab gastritis cov neeg mob.

Yog li ntawd, lub "Celebrex" tshuaj yog siv ntau npaum li cas lug tshaj lwm NSAID tshuaj, "naproxen", "Tshuaj aspirin", "ibuprofen".

directional

"Celebrex" tsiav tshuaj muaj peev xwm txo tau cov mob mob tej pob txha, nruj tshem tawm lawv paub daws ntev li o. Tej raug tau los kho cov neeg mob mob caj dab rheumatoid, osteoarthritis. Nyhuv ntawm cov tshuaj nce mus txog lub siab tshaj plaws cov nyhuv yog 24-48 teev tom qab thawj koob. Dysmenorrhea tshuaj zoo eliminates qhov mob, txawm lub feem ntau mob. Tsis tas li ntawd, nws yog zoo siv rau cov nyem mob tom qab phais (maxillo-lub ntsej muag thiab orthopedic phais).

Cov neeg mob uas ankylosing spondylitis tshuaj "Celebrex" txhob pathological dab thiab pab txoj kev lub cev muaj peev xwm los ua hauj lwm. Thaum tsom kwm tus muaj zog ntawm familial adenomatous polyposis siv ntawm cov tshuaj coj mus rau ib tug tseem ceeb yuav txo tau nyob rau hauv txoj kev loj hlob ntawm polyps nyob rau hauv cov nyuv thiab duodenum: txo lawv tus xov tooj thiab qhov luaj li cas. Cov kws kho mob hais tias tsim nyog koob tshuaj noj tshuaj thiab ua raws li kev kho mob kiag peev xwm ua tau zoo heev tau nrog rau cov kev siv ntawm "Celebrex" tshuaj. Testimonials qhia tsawg heev phiv thaum noj cov tshuaj no.

Tus duab thiab muaj pes tsawg leeg ntawm cov tshuaj

Heev xim inhibitor yog ib tug gelatin capsule yuav luag dawb los yog dawb, lawv yuav tsis tshab thiab cim nrog ib tug xiav ib daim hlab uas sau tias "7767" nyob rau ib sab thiab "100" thiab "200" nyob rau lwm yam. Tshuaj Ntsiav txheem: granulated dawb coloring.

Muaj pes tsawg leeg ntawm cov tshuaj muaj xws li: celecoxib (basic active ingredient), lactose, povidone K30, sodium sulfate lauryl, magnesium stearate, sodium croscarmellose. Lub plhaub yog ua los ntawm titanium dioxide, thiab siav gelatin. Yog hais tias tsim nyog cov thawj coj los ntawm cov tshuaj intramuscularly tshuaj tsa "Celebrex". Qhov no hom ntawm cov tshuaj yog tawm nyob rau hauv daim ntawv ntawm cov tshuaj cov kev txhaj tshuaj ntawm 2.2 ml ampoules - lub ntsiab yooj tshuaj celecoxib.

tshuaj

Cov tshuaj twb zoo absorbed rau hauv cov ntshav nyob rau hauv lub yoo mov lub xeev thiab nce mus txog ib tug ntau qhov kev ua tom qab txog 2-3 teev. Txawm li cas los, cov kev siv ntawm txhais tau tias ua ke nrog ib tug fatty khoom noj khoom haus yuav ncua nws txuam nrog rau 1-2 teev. Yog li ntawd nws yog tsim nyog los tham ib tug kws kho mob txog cov sij hawm ntawm kev noj cov tshuaj.

Ib zaug nyob rau hauv cov hlab ntsha, cov active tshuaj tsis khi rau cov ntshav liab, tab sis lub mechanism tsis cuam tshuam rau kev kawm tau ntawm cov kev kawm concentration ntawm cov tshuaj nyob rau hauv lub cev. Drug metabolized nyob rau hauv lub siab los ntawm oxidation thiab glucuronidation uas CYP2C9 enzyme. Tso zis txhais tau tias nrog zis thiab feces nyob rau hauv daim ntawv ntawm tej yam yooj yim metabolites, thiab tsuas yog 3% ntawm cov active tshuaj tseem unchanged.

Tshuaj "Celebrex", analogues ntawm uas yog zoo xws li cov nyob rau hauv muaj pes tsawg leeg, nyob txhais tau tias, yuav ua tau tsawg heev kev puas tsuaj rau kev noj qab nyob, vim nws muaj peev xwm yuav absorbed ntau li ntau tau thiab yuav luag tag tshem tawm ntawm lub cev. Nrog ib tug tsis muaj lub cev hnyav cai ib tug ntau dua concentration ntawm cov tshuaj nyob rau hauv cov ntshav, thiab qhov no tshwm sim yog cai ntau tshaj nyob rau hauv cov poj niam. Nws tsis yog lub npe hu yog vim li cas, tab sis kuj nyob rau hauv cov neeg dub pom tau tib puab. Yog li ntawd, cov pab pawg ntawm cov neeg mob tus kws kho ib tug tsawg dua koob tshuaj thaum pib ntawm txoj kev kho.

indications

Raws li ib tug uas tsis yog-tshuaj anti-inflammatory agents rau lub symptomatic tshuaj tshuaj "Celebrex". Indications rau kev siv:

• mob caj dab rheumatoid;
• osteoarthritis;
• spondylitis;
• algomenorrhea;
• mob mob (post-operative lub sij hawm, rov qab mob licas kab mob);
• siv nyob rau hauv kev kho mob ntawm adenamotoznogo polyposis.

Nws yuav tsum tau muab sau tseg uas txaus kho mob yuav tsuas muab ib tug kws kho mob rau lub hauv paus ntawm cov kev tshawb fawb.

Txoj kev ntawm cov thawj coj ntawm cov tshuaj

Noj cov tshuaj yuav tsum yog nyob rau hauv, tsis hais tus noj mov. Chewable ntsiav tshuaj yuav tsum tsis txhob yuav, koj yuav tsum tau haus dej ntshiab xwb. Nws yuav tsum tau muab sau tseg hais tias plawv mob yuav tshwm sim nrog mob thawj coj ntawm cov tshuaj. Yog li ntawd, cov kws kho mob muab cov tshuaj "Celebrex" ib tug luv luv chav kawm ntawm kev kho mob. Guest cov kws txawj kom paub tseeb tias lub siab tshaj plaws tshuaj rau long-term kho mob yuav tsum tsis pub tshaj 400 mg ib hnub twg!

• Kev kho mob ntawm osteoarthritis - txaus koob tshuaj yog 200 mg ib hnub twg. Sij hawm ntawm ib koob tshuaj los yog phua rau hauv ob (tu ncua).
• Mob caj dab rheumatoid - yuav tsum txhaj koob tshuaj ntawm 100 los yog 200 mg rau 2 lub sij hawm ib hnub. Thaum lub loj tshaj plaws ntaub ntawv - mus txog rau 400 mg ib hnub ob zaug.
• Ankylosing spondylitis - 200 mg ib hnub twg, rau 1 los yog 2 faib koob tshuaj. Nyob rau hauv tus kws kho mob yam lub koob yuav tau nce mus txaus luag
• Dysmenorrhea thiab muaj zog mob - pib kho nrog 400 mg ib hnub twg thiab ntxiv lwm 200 mg rau thawj hnub ntawm txoj kev kho, yog tias tsim nyog. Nyob rau hauv lub nram qab no hnub, koj yuav tsum coj 200 mg ib hnub ob zaug.

Duration ntawm kev kho mob yog txiav txim los ntawm lub mus kawm tus kws kho mob.

Contraindications rau kev siv ntawm cov tshuaj

Nyob rau hauv tas li ntawd mus tau kev tsis haum tshuaj rau cov pej xeem ntawm yeeb tshuaj, muaj kev txwv nyob rau hauv uas yog txwv tsis pub siv cov tshuaj "Celebrex":

1. Bronchial hawb pob, urticaria, tsis haum rau lwm narcotics yuav muab.
2. Lub postoperative lub sij hawm tom qab aortkoronarnogo bypass.
3. Peptic rwj (exacerbation).
4. GI los ntshav.
5. Inflammatory plob tsis so tswj kab mob.
6. Lub plawv tsis ua hauj lwm.
7. Loj hepatic insufficiency.
8. Raum insufficiency.
9. Cev xeeb tub thiab lactation.
10. Tsis pom zoo rau kev siv nyob rau hauv 18.
11. Npau taws me ntsis rau cov pej xeem ntawm cov tshuaj thiab sulfonamides.

Ceev faj yuav tsum tau siv cov tshuaj nrog kua tuav nyob rau hauv lub cev, cov kab mob ntawm cov hlab plawv system, mob ntshav qab zib.

phiv

Txawm tias lub siab potency ntawm cov tshuaj, heev los yog tsis txais tos hom thiab ntau npaum yuav ua tau tshwm sim los ntawm cov tshuaj "Celebrex". Testimonials qhia cov feem ntau (heev) cov tsos mob xws li:

• Cov kev tsis haum xws li pob, urticaria, pruritus.
• Flatulence, dyspepsia, edema, insomnia.
• Hnoos, txhaws ntswg, mob khaub thuas zoo li cov tshuaj tiv thaiv thiab ua pa ib ntsuj av tau kab mob.
• Mob txeeb zig.

Ntau tsawg muaj yog nce ntxhov siab vim, anemia, tinnitus, flushes, arrhythmia, arterial tawg. Ib txhia neeg raug kaw ulceration ntawm cov hnyuv, angionevropatichesky edema, tus tsim ntawm bullae ntawm daim tawv nqaij, exacerbation ntawm pancreatitis los yog nws txoj kev loj hlob, tsis meej pem. Tag nrho cov tsos mob yuav tsuas tshwm sim thaum ib lub chav kawm ntawm kev kho mob yog luv luv (mus txog 12 lub lim piam, tsis tshaj 800 mg rau ib koob tshuaj). Tab sis nyob rau hauv cov ntaub ntawv ntawm ntev-lub sij hawm kev kho mob (mus txog 3 xyoos) muaj cai:

• Common: siab ntawm ib lub rooj zaum, kub siab, mob pob ntseg, angina, heart attack myocardial infarction, xeev siab, dysphagia, prostatitis, nce creatinine.
• Ntau tsawg: arrhythmia, angina, ischemic stroke, atherosclerosis, teeb meem tsaug zog, paum los ntshav, mob rau sab hauv ntawm lub qhov ncauj, dysmenorrhea, nce nyob rau hauv hemoglobin, txo nyob rau hauv hematocrit.

Lub sis ntawm cov tshuaj nrog lwm yam tshuaj

Lub medicament koom biotransformed uas P450 2C9 (cytochrome). Nws yog yog li ntawd tau ncaj qha kev sis raug zoo ntawm cov tshuaj nrog rau lwm cov tshuaj mas siv:

1. Concomitant siv ntawm cov tshuaj "warfarin" tsub kom kev pheej hmoo ntawm neeg tuag taus los ntshav.
2. Kev npaj "Ketanazol" thiab "Fluconazole" ua rau kom cov concentration ntawm active tshuaj celecoxib yuav luag doubled.
3. Tau txais blockers los yog ACE inhibitors angiotenzita narcotics yuav muab tej zaum yuav txo tau lawv cov nyhuv antigipertinzivny
4. Thaum lawv tseem cov khoom uas muaj lithium, nws yuav ho ua rau kom cov ntshav theem.
5. Nws yog txwv tsis pub ib txhij siv cov tshuaj "Celebrex" analogs muaj celecoxib, lwm yam narcotics yuav muab!

tshuaj analogues

Nws yog ib nqi sau cia hais tias "Celebrex" tshuaj nqi tsis ntau heev, nws cov nqi yog nyob rau nruab nrab ntawm 400 rau 450 rubles. 10 tsiav tshuaj (100 mg ntau npaum). Txawm li cas los, xws kev kho mob yog kim heev rau tus neeg mob lub sij hawm ntev kho. Nyob rau hauv cov ntaub ntawv no, kev tso cai los ntawm ib tug kws kho mob, tsa cov neeg ua hauj muaj celecoxib. Rau tshuaj "Celebrex" analogues ntawm cov hauv qab no:

• tshuaj "Ranselak";
• tshuaj "Revmoksib";
• ntsiav tshuaj "Flogoksib";
• capsule "Artoksib".

Cov analogs muaj qhov tib active tshuaj thiab muaj ib tug ntau heev zoo tib yam kho nyhuv nyob rau hauv cov kev kho mob ntawm cov kab mob. Nco ntsoov tias ib tug txaus koob tshuaj ntawm ib tug analogue kuj muab nkaus xwb los ntawm lub mus kawm tus kws kho mob. Nyob rau hauv rooj plaub no tus kws kho mob txiav txim siab sib txawv pes tsawg leeg pab nyob rau hauv analogs, lawv muaj ntau yam additives li muab piv rau cov tshuaj "Celebrex". Instruction xyuas cov kws kho mob hais tau ntawm ib tug tsis haum cov tshuaj tiv thaiv los ntawm tus neeg mob mus rau lub cam sib txawv ntawm cov tshuaj ib pab pawg neeg.