"Budesonide": cov lus qhia rau kev siv thiab analogues. "Budesonide" nqus tau pa: xyuas, nqi

Asthma Qib thawj nyob rau hauv lub ntiaj teb no ntawm cov kab mob txuam nrog hyperactivity ntawm lub cev. Yuav kom kho nws tsim ib tug lossis loj npaum li cov tshuaj. Ib tug xws li lub cuab tam yog lub "budesonide". Analogs ntawm cov tshuaj no feem ntau kuj siv tau rau cov kev kho mob ntawm broncho-obstructive syndrome. Yog li ntawd yog dab tsi no tshuaj?

Yuav ua li cas yog "Budesonide"?

Qhov no tshuaj belongs rau ib pab pawg neeg ntawm nqus tau cov pa glucocorticoids. Qhov cuab yeej no yog ib tug hluavtaws analog tsim nyob rau hauv peb lub cev (nyob rau hauv lub adrenal cortex) cov tshuaj hormones. Yuav ua li cas hom ntawm cov nyhuv muaj "Budesonide"?

Cov lus qhia rau kev siv ntawm cov tshuaj ntawd hais tias tus neeg saib xyuas tsub kom tus nqi ntawm cov active beta-adrenergic receptors nyob rau hauv cov hlab cua.

Ntxiv mus, cov tshuaj blocks qhov kev txiav txim ntawm inflammatory prostaglandins thiab leukotrienes, li no tiv thaiv cov kev loj hlob ntawm o nyob rau hauv bronchial mucosa.

Nws niamntiav nws cov teebmeem tom qab hnub thawj coj li ob peb hnub (feem ntau yog hais txog 5-7 hnub).

Nws yog ib tug ntawm lub ntsiab tshuaj los kho tus mob mob loj heev bronchial hawb pob thiab mob obstructive koj muaj teebmeem kev kab mob. Nyob rau hauv thawj zaug rau theem ntawm txoj kev loj hlob ntawm cov kab mob tsis ua ntawv thov.

Yuav ua li cas, ces, "Budesonide" muaj ib cov nyhuv rau lub hom phiaj hlwb?

pharmacodynamics

Cov tshuaj los ntawm nqus tau pa daim ntawv thov, zoo absorbed ntawm tus nto ntawm lub ntsws (ntawm tus nto ntawm lub qhov ntswg mucosa yuav luag nce mus txog lub mauj kev).

Maximum ntshav concentration ntawm cov tshuaj yog cai tsis pub dhau 45 feeb tom qab nqus tau pa. 85 feem pua ntawm tag nrho cov khoom yeeb tshuaj uake rau albumin ntshav tshuav ib feem yog tas unchanged.

Nws yog ua los ntawm lub siab. Tas los rau ntawm lub cev los ntawm tus mob huam (nyob rau hauv cov kua tsib) thiab zis.

Cov neeg mob uas cov lub cev pathology pom lawm ncua lub tshuaj nyob rau hauv cov ntshav, yog dab tsi tau tshwm sim los ntawm txoj kev loj hlob ntawm feem ntau ntawm cov teeb meem thiab overdose ntawm glucocorticoid cov tshuaj hormones.

Nws yog tej zaum yuav siv cov tshuaj nyob rau hauv cov ntsiav tshuaj daim ntawv rau cov kev kho mob ntawm muaj quag connective cov ntaub so ntswg (tiam sis tsuas yog 10 feem pua ntawm tag nrho cov nqi ntawm cov tshuaj uas tau nkag mus hauv lub mob huam tej zaum yuav muaj ib tug kho nyhuv).

Nws kuj yuav siv los kho tus mob uas tsis yog-inflammatory kab mob ntawm lub qhov ntswg mucosa vim heev hauv zos kev txiav txim.

indications

Nyob rau hauv tej rooj plaub, txawm li cas los, koj yuav tau muab "Budesonide"? Cov lus qhia rau kev siv cov npe lub ntsiab kab mob nyob rau hauv uas cov tshuaj yuav siv tau:

• Bronchial hawb pob. Cov tshuaj ua nrov ua tsaug rau nws cov anti-inflammatory nyhuv thiab muaj peev xwm inhibit qhov kev ua si ntawm inflammatory kev sib kho.
• Crohn tus kab mob. Rau kho cov kab mob siv tableted daim ntawv ntawm cov tshuaj. Lub tshuaj no yog muab rau induce zam txim nyob rau hauv me me thiab loj tsawv ntaub ntawv ntawm tus kab mob.
• Kev kho mob ntawm txhaws ntswg. Nws qhia tau hais tias cov hauj lwm ntawm lub intranasal daim ntawv ntawm budesonide kev pab ntawm cov tsos mob ntawm hay fever thiab tsis haum txhaws ntswg. Ib qho zoo heev tus neeg saib xyuas los kho tus mob tus kab mob no yog "Budesonide Formoterol".
• Kev tiv thaiv ntawm kev rov muaj dua ntawm polyposis, qhov ntswg mucosa. Lub tshuaj no yog siv nyob rau hauv thaum ntxov postoperative lub sij hawm. Yuav luag 95 feem pua ntawm cov neeg mob tiv thaiv lub re-loj hlob ntawm polyposis.

Cov uas muaj npe kab mob yog lub ntsiab dab, nyob rau hauv uas lub koomhaum "budesonide".

Tej zaum, cov tshuaj yuav tsum muab los mus tiv thaiv cov kev loj hlob ntawm obstructive kab mob ntsws. Xws li mob muaj xws li cov neeg mob uas ua hauj lwm cov kab mob los yog ua hauj lwm nyob rau hauv tej hauj lwm tej yam kev mob. Tiam sis peb yuav tsum nco ntsoov hais tias txawm siv cov tshuaj rau kev tiv thaiv, peb yuav tsum tsis txhob hnov qab ceev faj dosing ntawm cov tshuaj, txij li thaum nkawd ib siab uas yuav muaj tau teeb meem nrog lub adrenal qog, thiab ntsoos ntsoos syndrome glucocorticoids.

Nyob rau hauv tej rooj plaub, txawm li cas los, nws siv yog txhob?

Contraindications

Nyob rau hauv dab tsi dab thiab cov kab mob, tsis txhob siv "Budesonide"? Cov lus qhia rau kev siv ntawm cov tshuaj qhia nram qab no cov kab mob:

• Nce rhiab heev mus rau yeeb tshuaj los yog nws cov yam. Risk ntawm cov angioedema.
• Lub active hauv daim ntawv ntawm tuberculosis.
• Kab mob ntawm cov pa fungal keeb kwm.
• Mob kab dab nyob rau hauv txoj hnyuv ib ntsuj av.
• Loj hepatic insufficiency.
• Cov me nyuam uas muaj hnub nyoog.

Nyob rau hauv tag nrho cov kab mob, kev siv ntawm corticosteroids yog txwv tsis pub. Qhov no yog vim lub fact tias cov tshuaj los yog txhawb cov txheej txheem exacerbate los yog paug nws chav kawm. Cov me nyuam muaj peev xwm siv tsis tau cov tshuaj no vim tias yuav cuam tshuam rau physiological zus tau tej cov glucocorticoid cov tshuaj hormones vim hais tias ntawm lub insolvency ntawm lub adrenal cortex.

Muaj ib co kev txwv, nyob rau hauv uas huab ceev faj yuav tsum raug siv "budesonide". Cov lus qhia nyob rau hauv daim ntawv thov ceeb toom tias zoo zoo heev yuav tsum tau siv cov tshuaj rau cov neeg uas kub siab, ntshav qab zib, pheochromocytoma, callous pais plab rwj thiab duodenal rwj.

sab nyhuv

Tam sim no muaj yog tsis muaj cov tshuaj, siv cov uas yuav tsis tau tsim ib tug sab nyhuv. Tu siab, "Budesonide" kuj yog ib tug tshuaj uas muaj ib tug ncaj loj spectrum kev phiv txheej xwm ntawm qhov kev txiav txim.

Yog hais tias koj siv "budesonide" inhalation, lub ntsiab tshwm sim los ntawm txoj kev siv yuav tsum yog ib tug hais lus ntshawv siab (dysphonia), txhaws qa, lub qhov ncauj qhuav, hnoos, paradoxical bronchospasm txoj kev loj hlob.

Thaum noj ntawm ncauj, tej zaum yuav tsim kev nyuaj siab, kiv taub hau, thiab txob taus.

Lub plawv system yuav hnov mob rau cov kev taw qhia ntawm "Budesonide" kev loj hlob ntawm vasculitis, ib qho kev nce nyob rau hauv mauj ntshav siab, tachycardia.

Cov tshuaj tej zaum yuav ua thiab aggravation ntawm txoj hnyuv kab mob - ulcers, pancreatitis. Nyob rau hauv tas li ntawd, nws nkoos txoj kev loj hlob ntawm dyspeptic ntshawv siab.

Nws tsis zoo muaj feem xyuam rau cov licas. Tej zaum qhov kev loj hlob ntawm txha, myasthenia Heavy kev, ob leeg mob.

Qhov loj tshaj plaws sab nyhuv yog Cushing tus syndrome. Nws tshwm sim vim lub fact tias thaum lub sij hawm lub sij hawm ntawm tau txais glucocorticoids decreases synthesis ntawm nws tus kheej cov tshuaj hormones. Yog hais tias corticosteroids siv rau ib ntev lub sij hawm, lub adrenal qog tej zaum yuav tsuas tu tsis tseg coj los ua ke physiological yam khoom uas tas cuam tshuam rau kev kho mob ntawm tus neeg mob. Uas yog vim li cas nws yog ib qho tseem ceeb los ua tib zoo saib xyuas cov tshuaj uas tau txais cov tshuaj hormones, raws li zoo raws li txoj cai kom tsis txhob noj lawv.

ntau npaum hloov

Nyob rau hauv dab tsi koob tshuaj yuav tsum tau muab "Budesonide? Cov lus qhia muab tshuaj muab cov nram qab no dosing regimen.

Siv nqus tau pa ntaub ntawv "budesonide" raws li lub heev ntawm tus kab mob no. Lub zoo koob tshuaj rau ib tug neeg laus yog 200-800 micrograms ib hnub twg. Qhov siab tshaj plaws txhua txhua hnub koob tshuaj yuav tsum tsis txhob ntau tshaj 1.5 mg. Nyob rau hauv cov me nyuam, cov tshuaj yog contraindicated rau cov kev siv, thiab nws analogs raug raws li lub heev ntawm lub rooj.

Lub qhov ncauj daim ntawv ntawm cov tshuaj no yog siv rau 30-60 feeb ua ntej noj mov. Siv txog li 3 mg 3 lub sij hawm ib hnub. Hoob no ntawm kev kho mob yog qhov ncauj noj tshuaj rau txog 2 lub hlis. Qhov tsis kam ntawm cov tshuaj yog nqa tawm maj mam mus tiv thaiv kom txhob ntsoos ntsoos cov tsos mob.

Intranasal feem ntau muab "Budesonide Iziheyler". Cov koob tshuaj yog xaiv ib lub zuj zus rau txhua tus neeg, nyob ntawm seb qhov heev ntawm tus txheej txheem. Nyob rau nruab nrab, lawv siv 2-3 dauv ntawm cov tshuaj nyob rau hauv txhua nostril ib hnub ob zaug. Nyob rau hauv cov me nyuam, qhov no daim ntawv ntawm cov tshuaj yog txhob. Hoob no ntawm kev kho mob yog rau 2 lub lis piam.

Sis nrog lwm yam tshuaj

Ib txhia ntawm cov tshuaj thaum uas siv nyob rau hauv ua ke nrog "Budesonide" yuav tsis tau nws cov haum. Cov tshuaj xws li inhibitors ntawm cytochrome P450. Piv txwv li, yog tias koj siv ob yam tib si "budesonide" ( "Pulmicort" - raws li ib tug analog) thiab cov tshuaj xws li "Ketoconazole" "Erythromycin" tej zaum yuav qeeb feem los ntawm cov ntshav ntawm ib tug glucocorticoid, uas yog fraught nrog txoj kev loj hlob ntawm hormonal intoxication thiab cov tsos ntawm phiv los ntawm cov tshuaj.

Concurrently tau txais "Budesonide" thiab ib txhia diuretics ( "Indap") muaj txhawb rau txoj kev loj hlob ntawm hypokalemia nyob rau hauv tus neeg mob, uas yuav undoubtedly kev cuam tshuam rau cov chaw ua hauj lwm ntawm lub plawv.

Ob peb tshuaj (e.g., antacids - "Almagel") thaum siv ib lub "budesonide" pheev rau txhua lwm yam antagonistic nyhuv, i.e. tsis pub txhua lwm yam mus rau pheev nws kho nyhuv. Vim hais tias ntawm no, nws yog pom zoo kom siv cov tshuaj ntawm ib tug caij nyoog ntawm tsawg kawg yog ob teev (tsuas yog siv rau lub qhov ncauj hauv daim ntawv ntawm cov tshuaj).

Siv cov tshuaj rau nqus tau pa

Txij li thaum cov tshuaj tau tsim feem ntau rau cov kev kho mob ntawm cov kab mob ntawm lub ntsws huam, nws yog tsim nyog los nkag siab nyob rau hauv dab tsi txoj kev yuav tsum raug muab rau lawv.

Nqus tau cov pa hauv daim ntawv ntawm cov tshuaj tsim heev heev, tab sis lawv siv feem ntau yog converges nyob rau hauv ntau txoj kev.

Firstly, cov tshuaj no feem ntau yog muab siv ib tug Cav Tshuab Pa Tshuaj. Qhov no tshuab tso cai rau koj mus nkag rau hauv cov hlab cua nruj me ntsis sib phim koob tshuaj. Feem ntau uas ploj lawm ib feem ntawm hmoov rau inhalation, mus ntes cov tsos mob ntawm kev mob hawb pob los yog COPD.

Rau lub hom phiaj no, feem ntau siv "Budesonide-haiv neeg." Qhov no tshuaj yog patented los ntawm cov Lavxias teb sab ruaj. Nyob rau hauv nws muaj pes tsawg leeg cov tshuaj yog ib ncua kev kawm ntawv ntawm (los yog hmoov) "Budesonide". Lub Cav Tshuab Pa Tshuaj loaded ib daig kab nrog rau cov tshuaj, ces inspiratory neeg sawv cev nkag mus rau hauv bronchi thiab lub ntsws.

Ob peb tshuaj muaj nyob rau hauv daim ntawv ntawm ib tug aerosol, uas tseem muaj "budesonide". Trade lub npe lawv tej zaum yuav txawv los ntawm txhua lwm yam, tab sis lub active ingredient yog tseem tib glucocorticoid. Yog hais tias noj xws li ib tug yeeb tshuaj, nws yuav tsum tau nco ntsoov tias twb tau txhaj ib koob ntawm aerosol muaj 0.05 ml ntawm cov budesonide (nws yog ib qho tseem ceeb kom paub tias nyob rau hauv thiaj li tsis mus ua ib tug overdose ntawm glucocorticoids).

Tus nqi ntawm cov tshuaj

Muab qhov luaj li cas ntawm cov tam sim no cov tshuaj ua lag luam tsis yog nyuaj rau tos rau lawv tus kheej, "Budesonide" rau nqus tau pa. Nws nqi thiab nws analogues tej zaum yuav txawv, tab sis nws yuav tsum tau nco ntsoov hais tias tias tag nrho cov tib nyob rau hauv lawv cov qauv ntawm lub ntsiab active khoom sib ua zaub mov yog budesonide. Tus nqi ntawm cov tshuaj yuav nyob ntawm seb leej twg yuav ua cov tshuaj, thiab seb nws yog ib tug patented tshuaj yeeb los yog generic tshuaj.

Cov tshuaj no yog muag heev dua lwm yam nyob rau hauv pharmacies. Yuav ua li cas npaum li cas yuav nws raug nqi "Budesonide"? Nws nqi thiab nws analogues yog ib tug nruab nrab ntawm los ntawm 300 mus rau 2000 rubles. Nws tag nrho cov nyob ntawm qhov uas yog lub chaw tsim tshuaj paus thiab cov uas daim ntawv ntawm cov tshuaj tso tawm. Piv txwv li, xws li ib tug yeeb tshuaj raws li "benacort" yog ua nyob rau hauv daim ntawv ntawm cov tshuaj nrog cov hmoov rau nqus tau pa. Nyob rau nruab nrab, nws cov nqi 400 rubles. British tshuaj ntau npaum li cas kim heev. Piv txwv li, "Budesonide Formoterol" British raug yog nyob hauv 2,000 rubles, tias tsis yog txhua yuav them taus. Cias yuav Slovenian khoom, uas tsis txawv nyob rau hauv kev ua tau zoo, thiab yog npaum li cas cheaper.

Nyob rau hauv cov kev tshawb fawb nws tau raug qhov tseeb hais tias qhov ntau kim tshuaj yog yuav luag tsis muaj txoj kev ua tsis tau zoo rau lawv cov nyiaj txiag counterparts. Yog li ntawd, yog dab tsi tshuaj yuav - cov kev xaiv ntawm txhua tus neeg, nyob ntawm seb nws xav tau kev pab thiab kev ruaj ntseg.

Xyuas ntawm kev npaj

Glucocorticoid tshuaj tau ntev tau siv los ntawm ntau cov neeg mob nrog rau cov syndrome mob obstructive los yog mob hawb pob. Yuav luag tag nrho cov neeg nrog ib tug loj heev hauv daim ntawv ntawm ib yam ntawm cov kab mob yog muab rau "budesonide". Nws analogues nyob ib tug ncaj dav ntawm tes rau hauv lub register ntawm cov tshuaj tiv thaiv cov kab mob, li ntawd, feem ntau yog hnov qhov txhia chaw. Cov tshuaj no xws li, piv txwv li, "Apulein" "Benakap" "Buderin", twb hais saum toj no "Pulmicort" thiab "benacort" thiab lwm yam

Raws li rau ntau cov neeg mob, cov tshuaj yog qhov zoo tshaj plaws nyob rau hauv cov kev kho mob ntawm cov kab mob ntawm lub ntsws ib ntsuj av. Kuj muaj ob peb cov neeg uas yuav tsis tau pab cov nqus tau pa hauv daim ntawv ntawm cov glucocorticoid los yog nws ua ke nrog beta-agonists.

Nrog zoo tshuaj dosing yog tau mus cuag ib tug tseem ceeb kev txhim kho nyob rau hauv cov neeg mob no. Tam sim no, muaj ntau yam tsuas yog tsis tau xeeb tub ntawm lub neej thiab lub neej zoo tsis muaj kev siv cov tshuaj no.

Txawm li cas los, txawm ntau cov zoo xyuas, muaj ib tug maub sab ntawm cov tshuaj raws li "Budesonide" - nqi.

Rau ib ntev lub sij hawm muaj ib tug ib txwm mus free lub sij hawm hawb pob tshuaj rau cov neeg mob nyob rau hauv kev xav tau. Tag nrho cov neeg mob yuav tuaj mus rau lub tsev muag tshuaj, thiab raws li thaum kev nthuav qhia ntawm cov ntaub ntawv kom tau free tshuaj rau lawv tus kheej xav tau kev pab.

Tam sim no, nws kuj yog xyaum, tab sis contingent, uas muaj cai los tso cov tshuaj ho roj. Tam sim no cov tshuaj yog dawb xwb tsuas rau cov neeg muaj kev tsis taus 1 thiab 2 pawg, raws li zoo li cov me nyuam; Lwm yam neeg tau mus yuav tshuaj rau lawv tus kheej nyiaj. Muab hais tias cov kev npaj yuav siv sij hawm heev heev, tsis yog txhua tus neeg muaj peev xwm them taus xws kev kho mob.