"Ademethionine": cov lus qhia rau kev siv, analogs, xyuas

Yuav ua li cas yog lub substance ademetionine? Cov lus qhia rau kev siv ntawm cov kev npaj, uas muaj ib tug tivthaiv uas yuav tau piav hereinafter. Peb kuj qhia koj txog yuav ua li cas npaum li cas nws cov nqi ib tug zoo li lub cuab tam uas cov neeg siv yog hais tias txog nws, thiab hais txog.

Daim ntawv ntawm cov tshuaj, nws cov hauj lwm

Nyob rau hauv dab tsi daim ntawv no yog muaj tshuaj "Geptral" (INN "Ademethionine")? Cov lus qhia rau Siv lub xeev hais tias qhov no cuab tam yog muaj nyob rau hauv ob tug sib txawv cov ntaub ntawv:

• Lub lyophilizate, npaj rau qhov kev npaj ntawm tso dej los yog intramuscular tshuaj. Daim ntawv no yog ib tug lyophilized loj ntawm dawb, uas tsis muaj kev txawv teb chaws inclusions. Tsis tas li ntawd, nyob rau hauv ib tug duab los qhia nras muaj ib tug tshwj xeeb kuab uas muaj hauv daim ntawv ntawm ib tug tsis muaj kob thiab pob tshab kua.
• "Ademethionine" - tshuaj nyob rau hauv ib tug dawb lub hnab ntawv, biconvex thiab dawb. Tsis tas li ntawd homonymous active tshuaj, qhov no txhais tau tias muaj thiab koom haum pab hais xws li cov Msc, Na-carboxymethyl silica thiab stearate Mg.

pharmacodynamic yam ntxwv

Yuav ua li cas lub zog ntawm cov tshuaj yeeb dej caw ademetionine? Daim ntawv thov lus qhia hais tias hais tias muaj teev choleretic, holekineticheskoe, detoxifying, neuro- thiab hepatoprotective thiab anti-depressant thiab antioxidant teebmeem.

Yog li, nws muaj kev ruaj ntseg kom nco ntsoov tias qhov suav hais tias cov tshuaj lub caij uas muaj peev xwm ntawm mus pab tau txoj lub tso pa tawm ntawm cov kua tsib, thiab ntxias nws sib cais nyob rau hauv cov hnyuv.

Tsis tas li ntawd nco ntsoov tias cov tshuaj "Ademethionine" analogs uas muaj qhia hauv qab no, nyob lub shortage SAM, tiam sis nws kuj nkoos tsim nyob rau hauv lub siab. Tsis tas li ntawd, qhov no txhais tau tias zoo tsub kom cov ntshav concentration ntawm cysteine, taurine, Glutamine cov ntsiab lus nyob rau hauv lub siab, yog li normalizing lub metabolic dab nyob rau hauv lub siab thiab txo cov theem ntawm methionine nyob rau hauv cov ntshiab.

Nyob rau hauv dab tsi tej yam kev mob txhais tau tias "Ademethionine" feem ntau zoo? Cov lus qhia rau kev siv qhia tau tias cov tshuaj no ua zoo nrog ductal thiab tubular hepatic cholestasis. Nws ua conjugation LCD thiab sulfation nyob rau hauv lub siab lub hlwb, thiab ces txo lawv toxicity.

Raws li cov ntaub ntawv ntawm cov kws txawj, choleretic thiab hepatoprotective los tom qab discontinuation ntawm txoj kev kho "Geptralom" khaws cia rau 3 lub hlis.

Thaum muab qhov no txhais tau tias cov neeg uas muaj opioid yees, ua raws li los ntawm daim siab tus kab mob, nws pab no hloov khoom nruab nrog muaj nuj nqi monooxygenase oxidation dab, tab sis tseem muaj txhawb rau regression ntawm kev soj ntsuam cov tsos mob ntawm tshuaj ntsoos ntsoos.

Antidepressant nyhuv tom qab daim ntawv thov ntawm no yeeb tshuaj muaj maj. Txawm li cas los, nws yuav tswj tshaj yav dhau los ob lub lim piam.

txhais tau tias cov muaj peev xwm ntawm cov kev tig tau

ib tug kho "Ademethionine" absorbed? Cov lus qhia rau kev siv ntawm cov lus ceeb toom uas hais nws cov bioavailability yog 5%, thiab thaum uas siv cov kev txhaj tshuaj - 100%.

Lub ncov concentration ntawm cov tshuaj nyob rau hauv cov ntshav thaum lub sij hawm ib koob tshuaj ib ntsiav tshuaj yog cai rau 2-6 teev.

Cov ntshav protein-ua txhua yam lub xeev ntawm no neeg sawv cev no tsuas yog nyob rau hauv me me qhov ntau. Nws yuav tsum tau muab sau tseg tias cov tshuaj penetrates zoo rau hauv lub BBB, thiab nyob rau hauv siab ntau yuav muab tau yooj yim kuaj txawm nyob rau hauv lub hlwb txha nqaj qaum kua.

Biotransformation ntawm cov tshuaj yog raug nyob rau hauv lub siab. Nws tshem tawm ib nrab-lub sij hawm yog 1.5 sij hawm. Muab tshuaj nyob rau hauv lub ob lub raum.

Indications rau los ntawm cov txhais tau tias

Vim li cas peb yuav tsum tau ib tug kho "Ademethionine" (tus nqi ntawm cov tshuaj teev rau hauv qab no)? Qhov no tshuaj yog feem ntau kws kho rau:

• cov tsos mob ntawm kev nyuaj siab;
• intrahepatic cholestasis thiab nyob cirrhotic pretsirroticheskih lub xeev, xws li hepatic steatosis;
• mob cholecystitis tsis muaj pob zeb;
• tus kab mob siab;
• cholangitis;
• tshuaj lom hepatic txhab ntawm txawv keeb kwm, nrog rau tus kab mob, haus dej cawv thiab tshuaj yeeb (tricyclic antidepressants, tshuaj tua kab mob, antivirals, antitumor thiab anti-TB tshuaj, qhov ncauj contraceptives);
• mob npuas paug;
• intrahepatic cholestasis nyob rau hauv cev xeeb tub cov poj niam;
• encephalopathy, nrog rau txuam nrog hepatic insufficiency (cawv).

Bans kev siv cov

Nyob rau hauv dab tsi tej yam kev mob yuav tsum tsis txhob muab cov tshuaj "Ademethionine" los yog "Geptral"? Qhov no txhais tau hais tias tsis tau siv nyob rau hauv kev tshuaj ntsuam genetic mob rau lub methionine voj voog, raws li zoo raws li yuav ua tau rau hyperhomocysteinemia los yog homocystinuria. Tsis tas li ntawd nws yog txhob tau txais nyob rau hauv thaum yau thiab thaum tiav hluas thiab siab rhiab heev rau ademetionina.

Dosing "Ademethionine" Ntsiav tshuaj

Guest cov kws txawj hais tias deals nrog cov txhais tau tias yuav tsum tau noj nyob rau hauv nruab nrab noj mov nyob rau hauv thaum sawv ntxov, tsis crushing los yog zom. Nyob rau hauv cov ntaub ntawv no, cov ntsiav tshuaj yuav tsum tau muab tshem tawm los ntawm lub ntim ncaj qha ua ntej noj.

Lub sij hawm ntau npaum ntawm cov tshuaj no yog 2-4 ntsiav tshuaj, thiab ntev ntawm txoj kev kho nyob rau hauv lub muaj pov thawj.

Cov lus qhia rau kev siv ntawm cov tshuaj

Yuav ua li cas kuv yuav tsum tau siv tshuaj tshuaj "Ademethionine" analogues uas yuav tsum tau nyob rau hauv tej lub tsev muag tshuaj? Tej kev npaj no muag nyob rau hauv ampoules, intramuscularly los yog intravenously. Yog li tso dej txhaj yog nqa tawm heev maj mam.

Cov tshuaj tov yog npaj cia li ua ntej ib tug txhaj siv ib tug lyophilized hmoov rau dilution kuab uas yog nyob rau hauv ib tug duab los qhia pob.

Tom qab txhaj tshuaj ntawm lub seem tshuaj yuav tsum tau muab pov tseg.

Nws yuav tsum tau muab sau tseg tias injectable daim ntawv "ademethionine" incompatible nrog alkaline daws thiab formulations uas muaj ib tug Ca ions.

Lub sij hawm ntau npaum ntawm neeg sawv cev rau TOLC 1-2 ampoules. Kev kho mob nrog rau qhov no medicament kav ob lub lis piam.

Thaum muaj kev nyuaj siab qhov suav hais tias cov tshuaj no yog siv nyob rau hauv ib tug zoo xws li cov koob tshuaj. Thaum zoo li no txhaj yog nqa tawm rau 15-18 hnub.

Yog hais tias tus neeg mob yuav tsum tau pab txhawb nqa kev kho mob, ces twb pauv mus rau cov ntsiav tshuaj daim ntawv "Heptral".

phiv

Yuav ua li cas tsis zoo tshua yuav ua rau cov tshuaj "Ademethionine" (400 mg) Ntau zaus thaum lub sij hawm kev kho mob nrog cov tshuaj no nyob rau hauv cov neeg mob muaj mob raws plab, mob plab thiab xeev siab.

Nyob rau hauv tsawg tus neeg mob txoj kev siv cov "Geptral" tshuaj, raws li zoo raws li nws cov ntsiav tshuaj daim ntawv yuav ua rau txoj kev loj hlob ntawm:

• IMP (i.e. mob txeeb zig);
• laryngeal edema, npau taws me ntsis kev tshua;
• paresthesia, ntxhov siab vim, mob taub hau, insomnia, kiv taub hau, tsis meej pem;
• khaus, daim tawv nqaij ces ua xua, ua pob ua xyua, angioedema, tawm hws;
• o ntawm cov phab ntsa ces dag leeg, mob ntawm lub plawv thiab cov hlab ntsha, kub flashes;
• tsam plab, qhov ncauj qhuav, ntuav, esophagitis, xeev siab, mob plab, raws plab, dyspepsia, tej mob ntawm lub digestive ib ntsuj av tau, tsam plab, biliary Colic, daim siab mob npuas paug, los ntshav los ntawm ntau yam GI huam;
• mob tej pob txha, cov nqaij leeg spasm;
• malaise, kab mob khaub thuas zoo li syndrome, ua npaws, ua daus no, peripheral edema, asthenia.

Tus nqi ntawm cov tshuaj, analogs thiab xyuas

Yuav ua li cas npaum li cas yog cov tshuaj no raws li "Ademethionine"? Tus nqi ntawm cov khoom no yog hais txog 1,500 rubles ib ntsiav tshuaj daim ntawv thiab hais txog 1900 rubles ib txhaj tshuaj.

qhia medicament yuav hloov yog tias yam xws li lub "glutamic acid" "Karnith" "Histidine" "carnitine", "Epilapton", "Elkar".

Yuav ua li cas cov neeg no hais txog cov tshuaj cov neeg siv? Raws li cov lus ceeb toom ntawm cov neeg mob uas muaj tej daim siab tus kab mob tshuaj "Ademethionine" yog lub tiag tiag xwb ua hauj lwm gepatoprotektor. Cov neeg mob uas muaj tus mob ntawm "mob npuas paug" cam hais tias qhov zoo tshaj plaws kev kho mob tau yuav tiav tau tsuas yog hais tias tus active tshuaj noj 2 zaug ib xyoos 3 lub hlis kev kawm.

Raws li rau cov kws kho mob, lawv qhia tias cov tshuaj "Ademethionine" tsis muab ib tug qhia thiab ceev ceev cov nyhuv hauv inflammatory kab mob ntawm lub siab, ua raws li los ntawm stagnation ntawm cov kua tsib nyob rau hauv cov ntaub so ntswg ntawm lub cev.