Cov tshuaj "Pyrazinamide" muaj cov kab mob bactericidal los yog bacteriostatic anti-tuberculosis tshwm sim nyob ntawm seb cov concentration. Qhov kev ua ntawm cov tshuaj no tsuas yog khaws cia hauv cov neeg mob acidic (ntawm pH ntawm 5.6 thiab qis dua). Ntawm lub Qhov kev tiv thaiv ntawm kev ua haujlwm, qhov tshwm sim ntawm qhov uas siv cov tshuaj siv nrog lwm cov tshuaj tiv thaiv antituberculous, yog ua tau rau kev npaj tshuaj. Cov tshuaj "Pyrazinamide" (qhov kev qhia rau kev siv ua qhov no pom zoo) yog qhov zoo tshaj plaws hauv kev puas siab ntsws, uas tau pom thawj, thaum muaj caseous-pneumonic yam, tuberculoma, caseous lymphadenitis. Cov tshuaj txo txoj kev thauj tshuaj ntawm urate thiab uric acid, tuaj yeem ua rau cov neeg hyperglycemia. Cov tshuaj los ntawm lub plab tsiv yog yuav luag tag nrho thiab sai sai absorbed. Nrog cov ntshav proteins, cov tshuaj khi rau 10-20%. Tom qab ib teev los yog ob, qhov siab tshaj plaws ntawm cov tshuaj yeeb tshuaj. Cov tshuaj zoo muab faib rau cov kua thiab cov nqaij, muab tso rau hauv lub cev, nrog rau lub ntsws, lub siab, lub raum, thiab cov cheeb tsam ntawm tuberculous lesion. Cov khoom kis mus rau BBB. Metabolism hauv lub siab yog tshwm sim.
Kev qhia
Cov tshuaj "Pyrazinamide" (kws tshawb fawb kev txhim kho qhov tseeb) yog qhov kev xaiv thawj zaug hauv kev kho mob ntawm tuberculosis.
Dosing regimen
Nws tau tsim kho tias monotherapy tsis zoo txaus. Txuas ntxiv rau qhov no, cov tshuaj "Pyrazinamide" raug nquahu kom siv nrog lwm cov tshuaj nrog kev tiv thaiv tuberculosis. Rau cov neeg laus, qhov noj tshuaj yog 30-35 mg / kg ib hnub. Rau cov neeg mob uas hnyav tsis tshaj li tsib caug kilograms, qhov koob tshuaj no yog sib npaug rau peb lub ntsiav tshuaj (1.5 g). Nrog ib tug loj ntawm ntau tshaj 50 kg yuav tsum tau 4 tab. (2 g). Rau cov me nyuam, qhov ntau npaum li cas tsuas yog 2 grams. Cov tshuaj yog noj nrog khoom noj. Nws pom zoo kom haus cov tshuaj thaum noj tshais.
Txhais tau tias "Pyrazinamide". Lus qhia rau kev siv. Cov lus qhia tshwj xeeb
Cov tshuaj no tsis ua rau ntau tshaj yog tias cov tshuaj ntawm tus kws kho mob tau pom. Thaum noj cov tshuaj loj, muaj kev tsis zoo los ntawm lub hauv paus ntawm lub paj hlwb - kiv taub hau, mob taub hau thiab lwm tus. Muaj ib qho teeb meem nyob rau hauv lub siab, tej zaum dyspepsia. Tshuaj lom neeg ua rau pom mob. Ua ntej thiab thaum lub sij hawm tus kab mob TB kev kho mob nyob rau hauv cov neeg mob ntau tshaj li 60 xyoo yog nqa tawm txhua hli xyuas ntawm kev ntsuas ntawm bilirubin, AST, uric acid thiab ALT. Hauv kev ntshawv siab ntawm lub siab ua haujlwm, kev siv tshuaj tawm yog tsim nyog. Cov neeg mob ntshav qab zib feem ntau yuav mob hypoglycemia. Thaum ua ke nrog kev siv tshuaj "Rifampicin" tuaj yeem sau cia rau hepatotoxicity. Nyob rau hauv daim ntawv thov nrog cov tshuaj Probenecid, qhov txo qis yuav raug thiab, vim li ntawd, muaj cov tshuaj lom ntau zuj zus. Tej zaum yuav muaj kev sib nkag siab nrog cov tshuaj "Isoniazid", "Ethionamide", acid ntawm nicotine thiab lwm yam txhais tau tias muaj cov qauv zoo sib xws. Cov tshuaj "Pyrazinamide" (kev qhia rau kev siv ua qhov no pom zoo) yog tsim rau tsib xyoos. Khaws cov tshuaj nyob rau hauv kaw ntim, nyob rau hauv qhov chaw tiv thaiv los ntawm lub teeb.