"Theophylline": cov lus qhia rau kev siv, analogs

Yuav ua li cas kuv yuav tsum tau siv cov tshuaj "Theophylline"? Cov lus qhia rau kev siv, analogs thiab cov yam ntxwv ntawm cov nyiaj yuav tau los sib tham tom qab.

Muaj pes tsawg leeg thiab zoo

Uas muaj cov tshuaj, "Aminophylline"? Cov lus qhia rau Siv hais tias lub active caij ntawm qhov cuab tam yog lub tib lub npe cov tshuaj yeeb dej caw - aminophylline.

Cov tshuaj no yog marketed raws li ib tug tshuaj rau tso dej cov thawj coj, raws li zoo raws li nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, muab tshuaj pleev los yog tshuaj pleev.

pharmacological nta

Yuav ua li cas yog lub tshuaj raws li "Theophylline"? Cov lus qhia rau kev siv (ampoules ntawm cov tshuaj no muaj peev xwm yuav tau nyob tej lub tsev muag tshuaj) qhia tias nws yog vasodilating, antispasmodic, diuretic thiab bronchodilatory tshuaj.

Lub active keeb ntawm cov medicament yog ib lub ntsev ntawm theophylline ethylenediamine. Nws muaj ib tug bronchodilatory nyhuv thiab ib tug cov hlab ntsws qhib, vim nws ncaj qha relaxant ntxim rau vascular du nqaij fibers ntawm lub ntsws thiab cov hlab cua. Cov nyhuv no yog tshwm sim los ntawm cov xim inhibition ntawm phosphodiesterase ua si, ua rau ib qho kev nce nyob rau hauv intracellular camp.

thaj chaw ntawm cov tshuaj

Lub zoo kawg li cuab tam "Theophylline"? Cov lus qhia rau kev siv hais tias nws yog tau txo tus hyperreactivity ntawm ua pa ib ntsuj av. Lub mechanism ntawm qhov kev txiav txim yog tseem tsis paub hais tias, tab sis cov kws txawj hais tias kev siv ntawm qhov suav hais tias cov tshuaj yuav ua rau ib qho kev nce rau hauv lub xov tooj thiab ua si ntawm T-suppressors nyob rau hauv cov ntshav.

Ua mucociliary clearance, nce lub contraction ntawm lub diaphragm, raws li zoo raws li stimulating txoj hauj lwm intercostal pa nqaij, lub cuab tam activates pa chaw, pab kom nws rhiab heev, thiab tej alveolar cua, uas thaum kawg ua rau yus mus rau ib tug txo nyob rau hauv lub multiplicity thiab heev ntawm apnea lub sijhawm uas nws.

Raws li ib cov nyhuv ntawm yeeb tshuaj, "Aminophylline"? Cov lus qhia rau kev siv (tshuaj pleev thiab kua muaj tib yam ntxim rau cov kab mob) qhia tias nyob rau hauv saib xyuas txhais tau tias lwm yam uas ua pa muaj nuj nqi, li no kev txhim kho cov ntshav O2 saturation txheej txheem thiab txo lub concentration ntawm cov pa roj carbon dioxide. Tsis tas li ntawd, active tshuaj yog tau mus tsim kho chaw dim pa ntawm hypokalemia.

Nws yuav tsum tau muab sau tseg kuj tau hais tias "Theophylline" cov lus qhia rau kev siv uas yog tau piav rau hauv qab no, activates lub plawv, tsub kom qhov zaus thiab lub dag lub zog ntawm lub plawv dhia, tsub kom qhov yuav tsum tau ntawm cov kev mob plawv nyob rau hauv lub O ₂ thiab ho tsub kom mob ntshav txaus.

Siv no formulation pab txo cerebral vascular laus, raum thiab daim tawv nqaij. Kws txawj hais tias qhov suav hais tias neeg sawv cev muaj diuretic thiab peripheral venorasshiryayuschim txiav txim txo pulmonary vascular kuj, lowers ntshav siab nyob rau hauv lub ntsig txog kev thiab nkoos ntshav txaus rau lub ob lub raum. Tsis tas li ntawd, qhov no formulation tej lub biliary ib ntsuj av tau thiab slows platelet adhesion thiab kev tso tawm ntawm kev sib kho ntawm npau taws me ntsis kev tshua, tswj lub phab ntsa ntawm lub mast hlwb, regulates lub microcirculation, txo txoj kev pheej hmoo ntawm thrombus tsim thiab pab txoj kev ruaj ntseg ntawm erythrocytes.

Nyob rau hauv loj koob tshuaj xam tau tias yog tshuaj qhia tau hais tias epileptogenic zog.

kinetics

Yuav ua li cas tig tsis yam ntxwv ntawm lub "Theophylline" txhais tau tias? Cov lus qhia rau kev siv (slimming kev npaj no yog siv ntau heev) qhia hais tias tom qab nkag mus rau tus tib neeg kab active keeb ntawm cov tshuaj yog metabolized nrog rau tom ntej tawm ntawm unbound theophylline, uas tom qab uake kom ntshav cov nqaijrog 40%.

Xam tias yog ib tug txhais tau tias muaj peev xwm mus txeem los ntawm cov placental teeb meem, raws li tau zoo raws li tso zis nrog leej niam cov kua mis.

Transformation theophylline ncua nyob rau hauv lub siab los ntawm cov enzyme cytochrome P450.

Lub daim ntawv pib ntawm cov tshuaj yog tso zis nyob rau hauv ib tug npaum li ntawm 10% nyob rau hauv cov zis. Lub ib nrab-lub neej lub sij hawm ntawm qhov cuab tam nyob rau hauv uas tsis yog-haus luam yeeb, raws li zoo raws li cov neeg mob kev txom nyem los ntawm bronchial hawb pob, yog 12 teev, nyob rau hauv cov me nyuam - 1-5 teev nyob rau hauv tus me nyuam mos - txog li 2 hnub, thiab nyob rau hauv haus luam yeeb - 4 teev.

Thaum muab?

Indications rau kev siv ntawm cov tshuaj nyob rau hauv tus duab ntawm nws tso tawm.

Parenteral thawj coj los yog pom zoo rau:

• ischemic mob ntawm cerebral ncig;
• raws li txoj cai asthmaticus ;
• tshuav ventricular tsis ua hauj lwm, uas yog nyuab los ntawm ua pa nyuaj siab, thiab bronchospasm;
• neonatal apnea;
• mob thiab mob lub plawv tsis ua hauj lwm;
• edema ntawm lub raum keeb kwm.

Nyob rau hauv tej rooj plaub, siv qhov ncauj "Theophylline" (ntsiav tshuaj)? Cov lus qhia rau kev siv cov ntawv qhia tias lub cuab tam ua zoo nyob rau hauv pulmonary lub plawv, broncho-obstructive syndrome ntawm txawv etiology (e.g., mob hawb pob, mob hawb pob, COPD, obstructive ntsws), pw tsaug zog apnea, ua lub siab nyob rau hauv lub ntsig txog kev, lub plawv tsis ua hauj lwm los ntawm mob los yog mob hom .

Contraindications

Thaum koj yuav tsum tsis txhob siv cov tshuaj "Theophylline"? Cov lus qhia rau kev siv ntawm cov lus ceeb toom hais tias nws yog ua rau:

• mob loj heev arterial hyper- los yog hypotension, tachyarrhythmia, ulcers ntawm lub digestive ib ntsuj av tau, nrog rau cov exacerbation;
• giperatsidnom gastritis, mob loj heev raum los yog hepatic muaj nuj nqi, hemorrhagic stroke, qaug dab peg, hemorrhage nyob rau hauv lub retina;
• simultaneous siv ephedrine nyob rau hauv cov me nyuam nyob rau hauv lub hnub nyoog ntawm 3 xyoo, muaj rhiab heev rau aminophylline los yog theophylline.

Tshuaj "Theophylline": cov lus qhia rau kev siv

Cellulite (tus neeg mob cov tswv yim yuav tsum tham txog hauv qab) yog ib tug txhais tau tias ntawm pab zoo zoo nkauj, tab sis qhov no yog tsis yog qhov hom phiaj tseem ceeb ntawm qhov suav hais tias cov tshuaj.

Yuav ua li cas kuv yuav tsum tau siv nws? Cov tshuaj regimen ntawm lub medicament neeg. Cov kev kho mob tsim los ntawm ib tug kws kho mob nyob rau hauv lub soj ntsuam daim duab, tus neeg mob lub hnub nyoog, thiab muaj cov pov thawj ntawm nicotine nyob tos.

Ib tug npaj nyob rau hauv daim ntawv ntawm ib tug tov yuav tsum muab intramuscularly los yog intravenously, raws li zoo raws li ib tug tshuaj pleev - thov kom muaj ib qhuav tawv nqaij nerazdrazhennuyu.

Raws li siv rau poob?

Yog nws tau siv lub poob tshuaj "Theophylline"? Cov lus qhia rau kev siv (ntawm cellulite yog ib lub cuab tam feem ntau siv rau hauv daim ntawv ntawm ib tug tshuaj pleev) muaj nyob rau hauv no hwm tsis muaj ntaub ntawv. Txawm li cas los, cov kws txawj cam hais tias lub active tshuaj ntawm cov tshuaj no yeej pab tau kom txo lub cev hnyav, tab sis kuj tej uas yuav tau tshem ntawm "txiv kab ntxwv tev". Yuav ua li cas no tshwm sim? Qhov tseeb hais tias aminophylline yuav txhim khu cov ntshav ncig nyob rau hauv cov ntaub so ntswg, raws li zoo raws li los txhim kho lawv cov kua muaj nuj nqi. Xws li ib tug yeeb tshuaj nyob rau hauv ntau cream rau cellulite (piv txwv li, "Turboslim», Draine Minceur, Reflexe Minceur, Phyto-Complexe, Zoo-up , lwm yam).

Schematics ntawm daim ntawv thov ntawm ointments nrog aminophylline nyob ntawm seb tag nrho cov muaj pes tsawg leeg thiab cov chaw tsim tshuaj paus.

phiv

Yuav ua li cas cov tshuaj tiv thaiv los ntawm qhov yuav tshwm sim los ntawm kev siv ntawm cov nyiaj? Raws li cov lus qhia, nws muaj peev xwm ua rau:

• pw tsis taus, ntxhov siab vim, kiv taub hau, convulsions thiab tshee;
• Gastroesophageal reflux, ntuav, raws plab, xeev siab, kub siab, anorexia, thiab exacerbation ntawm peptic rwj kab mob;
• mob arrhythmias, lub plawv mob, aggravation ntawm angina pectoris, siab yuav txo tau, cuav angina thiab tachycardia;
• hematuria, albuminuria;
• khaus, kub ib ce, thiab sawv pob;
• hypoglycemia;
• yaug kais dej, mob thiab induration ntawm lub qhov koob;
• tachypnea, albuminuria, mob hauv siab, hematuria, kub flashes, hypoglycemia, tawm hws thiab muaj zog txhua txhua hnub zis.

Sis thiab overdose

Kom txog rau thaum tam sim no, tus neeg mob tau qhia txhais tau tias ntawm cov ntaub ntawv lus overdose. Yog hais tias tus mob no tshwm sim, koj yuav tsum tsis txhob noj cov tshuaj thiab pib symptomatic kev kho mob.

Nyob rau hauv thaum uas tig mus noj cov tshuaj nrog sympathomimetics ib tug kev sib nrig sib ua kom cov lawv pharmacological kev txiav txim. Raws li rau beta-blockers, thiab lithium kev pab, qhov kev tsim nyog kev nqis tes ua yog nrog tsis muaj zog txaus.

Tus kho nyhuv "Aminophylline" markedly txo thaum nws yog siv ib txhij nrog cov "pentobarbital", "rifamycins", "Isoniazid", "Carbamazepine", "sulfinpyrazone," "Phenytoin" (xws li haus luam yeeb).

Action suav hais tias yog tshuaj tej zaum yuav muab tau ntau zog thaum co-xeem nrog quinolones, "lincomycin" macrolides "cimetidine", "Allopurinol" isoprenaline, beta-blockers, fluvoxamine, qhov ncauj contraceptives, "Disulfiram", "Viloksazinom", raws li zoo raws li thaum lub sij hawm kab mob khaub thuas txhaj tshuaj tiv thaiv .

Chelators thiab antidiarrheals txo adsorption "Aminophylline."

Analogs thiab cov neeg siv kev xyuas

Seb puas muaj cov analogs ntawm lub "Theophylline" tshuaj? Kws txawj teb rau lo lus nug no nyob rau hauv lub affirmative. Saib cov tshuaj yuav hloov tau "Aminophylline-esque", "Eufillin-Darnitsa", ntsiav tshuaj thiab tshuaj "aminophylline".

Yuav ua li cas cov neeg no hais txog lub hais tias txhais tau hais tias tau txais kev pab? Xyuas txoj kev npaj no yog heev heev. Feem ntau cov neeg mob tau qhia hais tias kev txhaj tshuaj "Aminophylline" yog ib tug pov thawj uas. Nws cov hauj lwm zoo thiab efficiency tsis ua kom muaj kev ntseeg, xws li cov kev tawm tsam ntawm mob hawb pob.

Raws li rau cov lus hais txog cov "Theophylline" lee, lawv yog cov muaj teeb meem. Ib txhia tau txais kev pab hais tias qhov no tshuaj yog tsis zoo. Txawm li cas los, muaj ib co neeg mob uas qhia impressive tau tom qab ua ntawv thov cov tshuaj pleev ntawm cellulite.