"Alfacalcidol": cov lus qhia rau kev siv, qhov kev tso tawm daim ntawv, xyuas, cov duab, ntau npaum, analogs

Tsis muaj vitamin D3 ua loj teeb meem. Rau cov me nyuam no tshaj yog fraught nrog txoj kev loj hlob ntawm rickets, thaum nyob rau hauv cov neeg laus uas tej zaum nws yuav zoo yuav ib tug tsis muaj ua ntawm txha thiab teeb meem zoo li.

Cov niaj hnub ua lag luam ntawm cov tshuaj muaj nws cov neeg muas zaub ib tug ntau ntawm cov tshuaj los mus tshem tawm cov tsis muaj peev xwm ntawm no vitamin. Ib tug xws li tshuaj yog "Alfacalcidol." Cov lus qhia rau kev siv characterizes nws raws li ib tug txhais tau tias zoo rau normalize lub vitamin-mineral tshuav nyiaj li cas.

pharmacodynamics

Qhov no medicament yog vitamin D3 active daim ntawv. Cov kev cai ntawm cov kev pauv tseem ceeb mineral tebchaw, xws li phosphorus thiab poov hlau, yog ib qho tseem ceeb feature ntawm cov tshuaj "Alfacalcidol." Siv cov tshuaj yog zoo nyob rau hauv stimulating pob txha tsim. Nyob rau hauv nws kev mus koom tes muaj zog haum ntawm calcium thiab phosphorus nyob rau hauv cov hnyuv thiab raum. Nyob rau hauv tas li ntawd, cov tshuaj no tsub kom cov pob txha ntxhia ceev thiab nyob rau tib lub sij hawm thiaj li muaj cov theem ntawm cov ntsiab lus nyob rau hauv cov ntshav PTH. Raws li ib tug yuav tau txais, "Alfacalcidol" muaj antirahitichnoe tej yam thiab yuav pab txo tau cov naj npawb ntawm cov pob txha lov.

Yog hais tias cov tshuaj yog coj kev kawm, ces nyob rau hauv nws lub hwj zoo sib haum, txo cov pob txha thiab cov nqaij mob (uas yog lub qhov tsim nyog tau los ntawm ib tug ua txhaum cai ntawm calcium-phosphorus metabolism).

Nyob rau hauv tej rooj plaub, kev txaus cai rau kev siv cov tshuaj?

"Alfakltsidol" cov lus qhia rau kev siv thiab kev cob qhia ntawm tus kws kho mob pom zoo kom muab cov tshuaj nyob rau hauv tus neeg mob qhov twg ib tug keeb kwm ntawm cov ntaub ntawv hais txog osteodystrophy, mob raum tsis ua hauj lwm theem. Ntxiv mus, nws yog siv nyob rau hauv hypoparathyroidism. Yog vim li cas rau nws yog lub hom phiaj rickets, osteomalacia (volume yuav txo tau ntawm cov pob txha ntaub so ntswg) thiab pob txha softening, qhov uas tej zaum yuav sib txawv heev. Txha - ib tug steroid, ua tem toob, postmenopausal - kuj ntse kho nrog "Alfacalcidol" txhais tau tias.

Cov kev xyaum ntawm appointing cov tshuaj nyob rau hauv tus neeg mob qhov twg tus neeg mob yog kev txom nyem los ntawm lub raum acidosis, los yog ib tug keeb kwm ntawm nws muaj Fanconi syndrome (a complex kab mob, xws li lub raum acidosis, kev coj tus kheej raws roj ntsha, nephrocalcinosis, rickets thiab tejzaum nws hypophyseal syndrome).

Nrog rau tag nrho cov teeb meem no, "Alfacalcidol" yuav muab zoo pab.

Thaum yuav tsum caiv txhob tau txais?

Daim ntawv teev cov contraindications mus rau yeeb tshuaj muaj "Alfacalcidol" phau ntawv qhia. Xyuas cov tub txawg tsis pub noj cov tshuaj uas muaj keeb kwm ntawm cov ntaub ntawv hypercalcemia, hyperphosphatemia (tsuas yog thaum loj hlob hyperparathyroidism), gipermagnemii. Tsis txhob siv cov tshuaj no nyob rau hauv cov ntaub ntawv ntawm intoxication ntawm ib tug kab mob txuam nrog ntev cov ntsiab lus ntawm vitamin D3. Nws yog tsis tsim nyog rau muab "Alfacalcidol" laus mums.

Zoo, needless hais tias, koj muaj peev xwm tsis noj tshuaj rau cov neeg uas ib tug neeg npau taws me ntsis mus rau yeeb tshuaj Cheebtsam.

Daim ntawv sau npe thiab ntau npaum

Cov feem ntau tag cov lus qhia txog yuav ua li cas siv thiab muaj dosing rau cov tshuaj "Alfacalcidol" phau ntawv qhia. Khoom daim ntawv (tsiav tshuaj ntawm 0.25 mg los sis 1), cov tshuaj thiab ntev ntawm kho cov hoob kawm tus kws kho mob xaiv ib lub zuj zus nyob rau hauv lub heev ntawm tus neeg mob tus mob thiab qhov xwm ntawm tus kab mob no.

Piv txwv li, ib tug neeg laus cov neeg mob uas rickets, tshwm sim los ntawm ib tug tsis muaj peev xwm ntawm vitamin D3, teeb meem nrog tus mob huam, yuav tsum tau txais rau ib hnub twg nyob rau hauv ib koob tshuaj nqi ntawm 1 mus rau 3 mg. Ib tug zoo tshwm sim nrog txoj kev kho rau hypoparathyroidism yuav raug los ntawm 2 mus rau 4 mg ntawm cov tshuaj ib hnub twg. Txhua hnub volume ntawm tsis ua hauj lwm thiab lub raum osteodystrophy kev ua si yuav tsum tsis txhob ntau tshaj tus nqi ntawm cov medicament mus rau 2 microgram. Fanconi syndrome thiab raum acidosis zoo raug raug kho "alfacalcidol" neeg mob uas tau txais ib tug txhua txhua hnub koob tshuaj nyob rau hauv ib tug ntim ntawm 2.6 micrograms. Nyob rau hauv lub xub ntiag ntawm cov neeg mob uas hypophosphatemic rickets thiab osteomalacia zoo txhua txhua hnub ntau npaum nqi yuav yog los ntawm 4 mus rau 20 micrograms.

Cov kws kho mob pom zoo kom koj pib kho mob nrog tus nqi qis tshaj koob, hais rau txhua tej kab mob. Cov kev kho mob yuav tsum tau soj ntsuam nyob rau hauv ntshav ntawm hais xws li calcium thiab phosphorus (tsawg kawg yog 1 lub sij hawm thaum lub sij hawm lub lim tiam). Ntau npaum "alfacalcidol" permissible nce los ntawm tsis muaj ntau tshaj li 0.5 micrograms ib hnub twg. Thaum qhov tsawg kawg nkaus zoo npaum yog pom, cov ntsiab lus ntawm calcium nyob rau hauv cov ntshav yuav tsum tsis tsawg tswj tshaj txhua txhua 3-5 lub lis piam.

undesirable los

Zoo li tej tshuaj noj, muaj yog ib daim ntawv teev kev phiv thiab txhais tau tias "Alfacalcidol." Cov lus qhia rau kev siv (synonymous, incidentally, kuj muaj cov nyhuv tib) coj mus rau cov xim ntawm cov neeg mob tias cov tshuaj yuav hnov mob mus rau lub digestive system. Nyob rau hauv feem ntau tus neeg mob, xeev siab, ntuav, epigastric mob, cem quav los yog raws plab, kub siab, zoo nkaus li ntawm dryness ntawm txheej week nyob rau hauv lub qhov ncauj. Yuav tshwm sim anorexia.

Cns tshwm sim muaj tshwm sim general tsis muaj zog thiab nkees nkees, qaug zog, mob taub hau thiab kiv taub hau. Tej zaum cov neeg mob hais txog txoj kev loj hlob ntawm tachycardia (sai lub plawv dhia) thiab nce nyob rau hauv cov ntshav siab. Dermatologic tshua yuav tshwm sim raws li khaus thiab ua pob ua xyua ntawm daim tawv nqaij, tsis heev intensive kev loj hlob ntawm cov pob txha, cov nqaij leeg thiab ob leeg kev mob kev nkeeg. Tej zaum yuav txawv dog dig kuaj qhov tseem ceeb ntawm ntau high-density lipoproteins. Muaj ib tug tau ntawm hypercalcemia, hyperphosphatemia (cov neeg raug kev txom nyem los ntawm kev txawv txav nyob rau hauv lub hauj lwm ntawm ob lub raum).

Ntev li koob tshuaj

Ib tug xov tooj ntawm tej yam tsis zoo tshwm sim yuav tsum muaj cai nyob rau hauv cov kev tshwm sim hais tias zoo tshaj permissible rau cov tshuaj "Alfacalcidol" npaum li cas. Cov lus qhia rau kev siv kom ceev faj txog cov neeg mob txog cov kev pheej hmoo ntawm kev tsim hypervitaminosis D. Thaum Ntxov overdose mob tshwm sim los ntawm hypercalcemia. Los ntawm cov brightest highlight tej tau hnyuv tshua, mob leeg, ib tug yog xim hlau saj nyob rau hauv lub qhov ncauj, nkees nkees.

Nyob rau hauv ntev intoxication cov neeg mob qhia koj nkees nkees thiab mob taub hau yuav tshwm sim tsis muaj zog, irritability, insomnia, nco puas, thiab ib tug me ntsis nce nyob rau hauv cov ntshav siab. Nyob rau hauv nyob tus yeees ntawm cov ntshav tej zaum muaj residual nqi ntawm nitrogen thiab creatinine. Muaj yog ib tug uas yuav ntawm conjunctival hyperemia, calcification ntawm raum, mob ntsws, nqaij mos thiab cov hlab ntsha, tsim ntawm concretions nyob rau hauv lub ob lub raum. Tej zaum yuav muaj teeb meem nrog lub suab (txhaws qa).

Yuav kom tshem tawm cov teebmeem ntawm ib tug overdose ntawm cov tshuaj yuav tsum tau abolished, plab ntxuav, muab, nyob ntawm seb cov tsos mob ntawm lub voj diuretics, bisfofonaty, hemodialysis siv tsawg feeb meej daws cov teeb meem ntawm calcium.

Cov kev txwv ntawm cov tshuaj

Muaj ib tug xov tooj ntawm cov kab mob nyob rau hauv uas nws yog tsim nyog los saib xyuas "Alfacalcidol." Cov lus qhia rau kev siv yog pom zoo kom ua tib zoo kho lawv lub xeev ntawm kev noj qab nyob rau cov neeg mob kev txom nyem los ntawm atherosclerosis, sarcoidosis (los yog lwm yam hom granulomatosis), pulmonary tuberculosis (active theem), lub plawv tsis ua hauj lwm thiab lub raum insufficiency kev ua si (mob daim ntawv no). Yuav ceev faj xaiv "Alfacalcidol" yog hais tias tus neeg mob nefrourolitiaza cov tsos mob. Cov me nyuam thiab cov neeg laus cov neeg mob kuj muaj teeb meem (rau tom kawg tshuaj yuav muab impetus mus rau lub kev loj hlob ntawm atherosclerosis).

Cev xeeb tub thiab lactation

Raws li rau cev xeeb tub cov poj niam thiab laus leej niam, cov "Alfacalcidol" qhia pub mus thov xwb nyob rau hauv tus neeg mob qhov twg cov kev tsim zoo sij hawm rau cov niam ntau tshaj qhov uas yuav kom tus me nyuam txoj kev noj qab thiab kev loj hlob.

Hypercalcemia nyob rau hauv lub expectant niam, provoked los ntawm ntev-lub sij hawm siv "alfacalcidol," yuav muab ib tug laub rau txoj kev loj hlob ntawm ib tug xov tooj ntawm cov teeb meem nyob rau hauv lub fetus. Ntawm feem ntau loj heev cov kab mob nyob rau hauv tus me nyuam hauv plab yuav raug hu ua npau taws me ntsis rau vitamin D, kev quab yuam ntawm cov hauj lwm ntawm lub parathyroid caj pas, aortic stenosis, hlwb ruamqauj, kev elfopodobnoy sab nrauv syndrome.

Nyob rau hauv tas li ntawd, "Alfacalcidol" nyob rau hauv me me tagnrho muaj peev xwm thaum lub sij hawm lactation tas nyob rau hauv niam cov kua mis. Yuav kom tsis txhob muaj cov kev pheej hmoo ntawm hypercalcemia cov tsos mob nyob rau hauv ib tug me nyuam, nws yog tsim nyog los systematically noj cov tshuaj nrog ceev faj.

Sis nrog rau lwm cov tshuaj

"Alfacalcidol" Neeg Daim Ntawv Thov pom zoo tsis mus txais mus tib seem nrog anticonvulsant (barbiturates, phenytoin, thiab hais txog. D.) Nyob rau hauv view ntawm ua nws cov ( "alfacalcidol") metabolism. Tus txheem cawv inhibitors. Daim ntawv thov ntawm tus medicament nyob rau hauv nrog cov neeg ua hauj muaj digitalis, yuav ntxias txoj kev loj hlob ntawm arrhythmias.

Ho dua li qub haum "alfacalcidol" nyob rau hauv uas tig mus rau nws mus kawm rau albumin, antacids, ntxhia roj, colestipol, colestyramine, sucralfate.

Lub ua ke ntawm magnesium-muaj cov tshuaj ntaus cev los yog antacids, tsub kom qhov yuav ntawm gipermagniemii los yog giperalyuminemii. Nyob rau hauv ua ntawv thov cov "alfacalcidol" muaj tshuaj, muaj nyob rau hauv nws muaj pes tsawg leeg vitamin D los yog nws derivatives, tsub kom kev pheej hmoo ntawm hypercalcemia.

Toxic los "alfacalcidol" yog considerably txo nyob rau hauv thaum uas tig mus nrog nws daim ntawv thov ntawm tocopherol, ascorbic acid thiab pantothenic acid, Thiamin, riboflavin, vitamin A. Cov nyhuv ntawm raug "alfacalcidol" yog tsawg pronounced nyob rau hauv lub xub ntiag ntawm derivatives thiab etindronoy pamidronic acid, glucocorticoids, kaltsitona. Nyob rau hauv tas li ntawd, cov tshuaj no nkoos haum ntawm phosphorus-muaj cov ntaub ntawv, uas tsub kom kev pheej hmoo ntawm kev tsim hyperphosphatemia.

zoo xws li cov tshuaj

muaj dav rau tshuaj "Alfacalcidol" analogues nyob rau hauv tus kws ua lag luam ntawm lub teb chaws. Cov lus qhia rau kev siv cov kev qhia rau qhov zoo tshaj sawv daws yuav. Cov no muaj xws tshuaj "Etalfa", "Alpha-D3 Teva", "Ca-Alfadol", "Alpha-Wang", "Oksidevit", "Tevabon".

Cov tshuaj manufacturers muaj tau txais kev pab nyob rau hauv ib tug ntau yam ntawm cov ntaub ntawv: ntsiav tshuaj thiab gelatin tsiav tshuaj, dauv thiab hmoov, kev daws teeb meem tso dej raws leeg Txoj kev lis ntshav.

Xyuas ntawm kev npaj "Alfacalcidol"

Tej tshuaj muaj los ntawm UFW thiab tw, cia li raws li yog cov ntaub ntawv nrog qhov kev npaj "Alfacalcidol." Cov lus qhia rau kev siv, duab ntawm cov neeg mob uas txaus siab rau tus sib sib zog tsa rau hauv lub cev, ua kom nws ntshiab tau txais kev pab hais tias cov tshuaj yuav ho txhim kho ib tug neeg muaj lub neej zoo nrog ib tug xov tooj ntawm cov kab mob txuam nrog ib tug tsis muaj peev xwm ntawm cov vitamins thiab minerals, cov calcium-phosphorus metabolism. Nyob rau hauv tas li ntawd, "Alfacalcidol" yog tau tsuas txhim kho cov mob ntawm cov plaub hau thiab rau tes, uas yog tseem ceeb heev.

Ib txhia neeg tsis txaus siab nrog lub fact tias "Alfacalcidol" tsis tau muas ntawm tus qhib kev ua lag luam, raws li nws yuav tsum tau ib tug tshuaj los ntawm ib tug kws kho mob. Txawm li cas los, noj qab haus huv cov tub txawg yog ntawm lub tswv yim hais tias xws li loj npaj, thiab yuav tsum tsis txhob muaj kev yoojyim mus rau txhua leej txhua tus.